Intertwined Relationship Research Articles

Complementary value of molecular, phenotypic, and functional aging biomarkers in dementia prediction.

DNA methylation age (MA), brain age (BA), and frailty index (FI) are putative aging biomarkers linked to dementia risk. We investigated their relationship and combined potential for prediction of cognitive impairment and future dementia risk using the ADNI database. Of several MA algorithms, DunedinPACE and GrimAge2, associated with memory, were combined in a composite MA alongside BA and a data-driven FI in predictive analyses. Pairwise correlations between age- and sex-adjusted measures for MA (aMA), aBA, and aFI were low. FI outperformed BA and MA in all diagnostic tasks. A model including age, sex, and aFI achieved an area under the curve (AUC) of 0.94 for differentiating cognitively normal controls (CN) from dementia patients in a held-out test set. When combined with clinical biomarkers (apolipoprotein E ε4 allele count, memory, executive function), a model including aBA and aFI predicted 5-year dementia risk among MCI patients with an out-of-sample AUC of 0.88. In the prognostic model, BA and FI offered complementary value (both βs 0.50). The tested MAs did not improve predictions. Results were consistent across FI algorithms, with data-drivenhealth deficitselection yielding the best performance. FI had a stronger adverse effect on prognosis in males, while BA's impact was greater in females. Our findings highlight the complementary value of BA and FI in dementia prediction. The results support a multidimensional view of dementia, including an intertwined relationship between the biomarkers, sex, and prognosis. The tested MA's limited contribution suggests caution in their use for individual risk assessment of dementia.

The relationship between personal-collaborative motivation profiles and students’ performance in collaborative problem solving

Collaborative problem solving (CPS), as a twenty-first century skill, is critically important for both living and life-long learning. Motivation in CPS equates to students’ needs to recognize their efforts in collaboration. Given the complexity of CPS contexts, the intertwined relationship among different types of motivations was investigated using a person-centred approach to identify different configural profiles of collaborators based on PSI (ψ\\documentclass[12pt]{minimal} \\usepackage{amsmath} \\usepackage{wasysym} \\usepackage{amsfonts} \\usepackage{amssymb} \\usepackage{amsbsy} \\usepackage{mathrsfs} \\usepackage{upgreek} \\setlength{\\oddsidemargin}{-69pt} \\begin{document}$$\\psi$$\\end{document}) theory. A total of 9398 Chinese students in 264 schools were included in this study. Latent profile analysis was used to identify four profiles of students with different CPS motivations: “Achievement-oriented cooperator” (n = 773), “Instrument-oriented Cooperator” (n = 1539), “Achievement-oriented nonteam player” (n = 1202), and “Instrument-oriented nonteam player” (n = 5884). Their psychological attributes and CPS behaviours were further analysed, with the following results: (1) achievement-oriented cooperators performed the best, while instrument-oriented nonteam players performed the worst; and (2) students who are achievement-oriented and value collaboration with others are more likely to engage in CPS tasks. These findings provide insights into how different motivational configurations influence CPS behaviours, offering practical implications for enhancing collaboration in educational settings.

Microtubule reorganization and quiescence: an intertwined relationship.

Quiescence is operationally defined as a reversible proliferation arrest. This cellular state is central for both organism development and homeostasis, its dysregulation causing many pathologies. The quiescent state encompasses very diverse cellular situations depending on the cell type and its environment. Further, quiescent cell properties evolve with time, a process that is thought to be at the origin of aging in multicellular organisms. Microtubules are found in all eukaryotes, and are essential for cell proliferation as they support chromosome segregation and intracellular trafficking. Upon proliferation cessation and quiescence establishment, the microtubule cytoskeleton was shown to undergo significant remodeling. The purpose of this review is to examine the literature in search of evidence to determine whether the observed microtubule reorganizations are merely a consequence of quiescence establishment or if they somehow participate in this cell fate decision.

Beyond the 'Protected Area' Paradigm in Conservation: Exploring India's Forest Legislation as a New Conservation Model for Developing Countries.

To achieve global biodiversity targets, expanding protected area (PA) networks has been regarded as a major strategy in international commitments. However, the PA strategy often fails to achieve its objective - preserving biodiversity and ecosystem services. In addition, the expansion of PA areas could replicate and amplify historical injustices such as forced evictions, state-led physical violence, assimilation of culture and loss of traditional ecological knowledge, affecting communities' livelihood, quality of life and rights. There is an increasing consensus that the post-2020 biodiversity conservation framework should be rights-based and sensitive to the role and contributions of local communities towards achieving the PAs' targets. India's Forest Rights Act (FRA) 2006 may be considered a useful framework for biodiversity conservation in the context of this new conservation vision. It puts local people at the centre stage, making them active participants in designing and managing conservation. PAs following 'fortress conservation' approach were based on the flawed idea that human interference endangers biodiversity and therefore habitats should be preserved by force if required. Such an idea contradicts the recent understanding that ecosystems once perceived as 'wilderness', have been transformed by people. PAs undermine the intricate and intertwined relationship of humans with their immediate ecosystem. The conservation model proposed by FRA 2006, on the other hand, recognises local communities as an integral part of ecosystem and thereby acknowledges people's rights and agency in conservation. It ensures locals' equitable benefits from economic activities, and provides equitable opportunities to participate in decision-making. Though various provisions under FRA empowered local people in conservation, it faces various challenges during the implementation on the ground. It is argued that a clear and appropriate institutional arrangement specifying various stakeholders' power, roles and responsibilities in the conservation and management of bioresources (including the protection of endangered species) should be developed for transformative change in biodiversity conservation.

Insights from triggers and prodromal symptoms on how migraine attacks start: The threshold hypothesis.

The prodrome or premonitory phase is the initial phase of a migraine attack, and it is considered as a symptomatic phase in which prodromal symptoms may occur. There is evidence that attacks start 24-48 hours before the headache phase. Individuals with migraine also report several potential triggers for their attacks, which may be mistaken for premonitory symptoms and hinder migraine research. This review aims to summarize published studies that describe contributions to understanding the fine difference between prodromal/premonitory symptoms and triggers, give insights for research, and propose a way forward to study these phenomena. We finally aim to formulate a theory to unify migraine triggers and prodromal symptoms. For this purpose, a comprehensive narrative review of the published literature on clinical, neurophysiological and imaging evidence on migraine prodromal symptoms and triggers was conducted using the PubMed database. Brain activity and network connectivity changes occur during the prodromal phase. These changes give rise to prodromal/premonitory symptoms in some individuals, which may be falsely interpreted as triggers at the same time as representing the early manifestation of the beginning of the attack. By contrast, certain migraine triggers, such as stress, hormone changes or sleep deprivation, acting as a catalyst in reducing the migraine threshold, might facilitate these changes and increase the chances of a migraine attack. Migraine triggers and prodromal/premonitory symptoms can be confused and have an intertwined relationship with the hypothalamus as the central hub for integrating external and internal body signals. Differentiating migraine triggers and prodromal symptoms is crucial for shedding light on migraine pathophysiology and improve migraine management.

Fostering employee autonomy through rewards: a self-determination theory perspective

Purpose This paper aims to explain and determine the effect of rewards on employees’ autonomy by investigating the mediating effect of enabling controls on their relationship. Design/methodology/approach A three-wave survey strategy has been used to collect data from the alumni of a French business school. Structural equation modelling has been used for measures validating and hypotheses testing. Findings The study reveals a positive relationship between rewards and autonomy, mediated by enabling controls. Practical implications The study guides the process of administrating rewards to employees in a way that maximizes their autonomy, highlighting the crucial role of supervisors through enabling controls. Originality/value The study strives to create consensus regarding the long-existing debate on the effect of rewards on employees’ autonomy with the help of organizational theory literature. By considering the role of enabling controls, it provides a unique, cohesive framework to illustrate the intertwined relationship between the constructs.

Exploring the group heterogeneity in the impact of social cohesion on the walking frequency of older adults in China.

Walkable neighborhoods are closely related to an increase in walking frequency and the strengthening of social cohesion. These factors, in turn, contribute to lower BMI and other positive health-related outcomes. However, with a rapid increase in aging populations in China and the fact that women are facing more challenges than men as they age, especially mobility challenges because they tend to live longer leading to probabilities to become widowed. Nevertheless, less attention has been paid to understanding the gender difference between these relationships. Based on a survey of 533 older adults in Dalian, China, this study tried to investigate the intertwined relationship between perceived walkability, social cohesion, walking frequency, and BMI. A Structural Equation Model (SEM) and multiple-group analysis were applied to test the proposed framework. First, results show that gender differences existed among the above interrelationships, and the most substantial gender gap was found in effects of social cohesion on BMI. Second, perceived walkability only has a direct effect (0.149) on walking frequencies for female seniors. Third, although the relationships between perceived walkability and BMI are not directly related in both male and female models, the indirect connection (-0.053) is substituted for female seniors. Besides, the inhibiting effect of walking on BMI, which is -0.511, is also valid for female seniors. Finally, in terms of the role of social cohesion, both the positive impacts of perceived walkability on it (0.225 for males and 0.325 for females) and its promoting effects on walking have been confirmed in male (0.142) and female models (0.103). The negative direct effect of social cohesion on BMI (-0.083) is only confirmed in male seniors. Insights derived from this analysis can help bring forward gender-specific interventions to build a more inclusive walkable and social environment to improve the mobility and physical health of older adults.

Baffled Labelling: Making Sense of the Intertwined Relationship between Fundraising Fraud and Illegally Taking in Deposits from the General Public in Chinese Criminal Law

AbstractFundraising fraud is one of the most serious and complicated financial crimes in China. It has an intertwined relationship with a regulatory offence, known as illegally taking in deposits from the general public (ITIDFGP). In judicial practice, ITIDFGP works as the downgraded form of fundraising fraud. This article explores why fundraising fraud is identified as financial fraud whereas ITIDFGP is a regulatory offence. The paper discerns the essence of fraud in Chinese criminal law and critically examines the concept of “intention to possess illegally.” It argues that ITIDFGP should be classified as a form of fraud de jure, although, in reality, there are policy considerations behind its categorization as a regulatory offence. The paper also suggests that the role played by the socioeconomic policy in Chinese criminal-law legislation should be fully acknowledged.

Intertwined relationship of dynamin-related protein 1, mitochondrial metabolism and circadian rhythm.

In recent years, mitochondria have gained significant interest in the field of biomedical research due to their impact on human health and ageing. As mitochondrial dynamics are strongly controlled by clock genes, misalignment of the circadian rhythm leads to adverse metabolic health effects. In this review, by exploring various aspects of research and potential links, we hope to update the current understanding of the intricate relationship between DRP1-mediated mitochondrial dynamics and changes in circadian rhythmicity leading to health issues. Thus, this review addresses the potential bidirectional relationships between DRP1-linked mitochondrial function and circadian rhythm misalignment, their impact on different metabolic pathways, and the potential therapeutics for metabolic and systemic disorders.

An unwelcome third party: the role of inflammation in the relationship between depression and Peyronie's disease.

The article "The Association Between Peyronie's Disease and Depression: A Scoping Review" explores the intricate relationship between Peyronie's disease (PD) and depression. Authored by Rune Kraglund, Emil Durukan, Annamaria Giraldi, and Mikkel Fode, the scoping review delves into shared risk factors such as obesity, smoking, and diabetes, potentially justifying the higher prevalence of depression in patients with PD. Interestingly, data suggest an increased risk of depression even before PD symptoms manifest, hinting at a complex interplay. The review emphasizes the relevance of systemic inflammation in the pathophysiology of both disorders. While bidirectional links between depression and inflammation are established in literature, PD's association with systemic inflammation adds a layer of complexity. Conditions such as cancer, linked to systemic inflammation, correlate with PD and depression, highlighting common pathways. Examining specific inflammatory markers, the article notes elevated levels of TNF, IL-6, platelet-derived growth factor, TNF-α, and fibroblast growth factor in PD and depressive disorders. The discussion extends to the scoping review's significance, emphasizing the often-overlooked correlation between psychiatric and sexual health disorders. Understanding the psychological aspects of PD is deemed crucial, considering that depressive conditions may affect treatment adherence and outcomes. The article acknowledges the challenge of establishing a causal link between PD's psychological impact and depression. However, it suggests a potential intertwined relationship where PD may lead to depression due to its impact on sexual function and self-esteem, while depression, in turn, enhances inflammatory responses and aggravates PD. In conclusion, the article proposes that the involvement of inflammation complicates the relationship between PD and depression. This complex interplay, though not fully elucidated in the current literature, provides a compelling theme for future studies, offering insights into the shared pathophysiology and potential paths for improved understanding and treatment of these interconnected disorders.

THE INTELLIGENCE AND SECURITY LANDSCAPE IN THE UK POST-BREXIT

On November 15, 2023, Professor Julian Richards presented The Intelligence and Security Landscape in the UK Post-Brexit for this year’s West Coast Security Conference. The presentation was followed by a question-and-answer period with questions from the audience and CASIS Vancouver executives. The key points discussed were the long-term and intertwined relationship between the UK and EU, the main dimensions that this relationship holds—being first of a strategic and military nature and second a homeland security focus—and the role of international conflicts in illustrating the military capabilities of the UK and EU following Brexit. 
 
 Received: 01-26-2024
 Revised: 01-29-2024

Engendering thunder: Imperial consorts, thunder ritual and the power of Daoist material culture at the Ming court

ABSTRACT This article delves into the world of powerful women at the Ming court and their patronage of Daoist ritual and visual arts, focusing on the significance of Thunder Ritual (leifa 雷法). By examining a painted ritual scroll of the Daoist exorcistic Thunder Deity Wang Lingguan 王靈官 (Efficacious Agent Wang), Wang Lingguan and His Retinue, this study unravels the connections between Daoist Thunder Ritual, court women and the realpolitik of the Ming court. The painting was commissioned in 1542 by the Jiajing Emperor’s 嘉靖 (r. 1521–1567) Honoured Imperial Consort Lady Shen (Huangguifei shen 皇貴妃沈), and the circumstances surrounding the commissioning of the scroll reveal an intertwined relationship between Daoist material culture and the religious identities of high-ranking court women. This study contributes to an ongoing scholarly re-visioning of Daoism’s critical role in Ming history by arguing that Wang Lingguan and His Retinue stands as a material witness to the significance of Thunder Ritual at Jiajing’s court and also serves as evidence of the important role that high-ranking court women’s patronage of Daoist art plays in the significance of Daoism during the Ming dynasty.

Symbiotic Relationships, Knowledge Management, and Sustainable Value at the Nexus Between Family Businesses, Cooperatives, and Rural Communities

The creation of value is a key theme in knowledge management. Researchers have identified that in rural communities, many family businesses are members of cooperatives or other consortia. Yet, there is limited understanding about how family businesses associated with a cooperative create and appropriate value. Based on an embeddedness perspective we argue that intertwined relationships between family, business, cooperative, and rural communities could create, appropriate, as well as destroy economic and social value, which can influence sustainability. We rely on a multiple case study approach of family businesses associated with a cooperative in Cyprus. Such an approach and setting are important, as they provide an opportunity to examine multiple contextual interactions. Our findings reveal the role of knowledge construction, knowledge transfer, and symbiotic relationships at the levels of family business, rural cooperative, and local community in powering processes of economic and noneconomic value creation, appropriation, and balance, which are important for community sustainability. Implications for researchers, practitioners, and policymakers, as well as future research opportunities, are presented.

ETEL ADNAN’IN JOURNEY TO MOUNT TAMALPAIS ESERİNDE SANAT, DOĞA VE BELLEK

In her Journey to Mount Tamalpais: An Essay (1986), the Arab American painter and poet Etel Adnan (1925-2021) contemplates on the relationship between art, nature, and memory by focusing on the act of perception. Adnan’s text tells of her inner journey towards peace in contrast to her other work that responds to the Lebanese civil war, from which she had to flee in the 1970s. The centrality of perception reveals an intertwining relationship between art, nature and memory. In this relationship, the subject is intertwined with the object, self with the other, the perceiver with the perceived, which traditional Western thought separates as binaries. One of the prominent figures in phenomenological approach, Maurice Merleau-Ponty has focused on perception that is compatible with Adnan’s text. His concepts of “reversibility,” “chiasm,” “dehiscence,” and “flesh” are useful tools to analyze the essay both in its conceptual and cultural dimensions. As a work which incorporates verbal and visual treatments of the mountain, in which Adnan excavates the hidden histories and memories, retaining their differences, Journey to Mount Tamalpais proves to be a manifestation of “the intertwining—the chiasm” as Merleau-Ponty attempts to map. In relation to perception, memory emerges as a preeminent concept due to Adnan’s engagements with cultures and linguistic worlds such as Arab, French and American, and her witness of colonial wars. This article proposes a reading that captures the conceptual and cultural dimensions of the text, which ultimately leads to a new visibility of the mountain. The ultimate manifestation of Mount Tamalpais is the image of a wise and wounded old woman. When the process of perception that produces this image is analyzed from Merleau-Ponty’s perspective, Journey to Mount Tamalpais reveals a way of thinking about the chiasm of art, nature and memory in which the boundaries between subject and object, perceiver and perceived, and background and foreground collapse.

Real-World Evidence of Intra-institutional Performance Variation in Indefinite Diagnosis of Pleural Effusion Cytology.

Pleural effusion cytology has been widely used in the investigation of pathologic fluid accumulation in pleural spaces. However, up to one-tenth of the cases were not given a definitive diagnosis. These cases have largely been neglected in the bulk of the literature. To provide real-world data on indefinite diagnoses including "atypia of uncertain significance" (AUS) and "suspicious for malignancy" (SFM) in pleural effusion cytology and to investigate pathologists' practice patterns on using these diagnostic categories. We reported the diagnoses of 51 675 cases. Descriptive statistics and correlation coefficients were used to analyze the relationships between different diagnostic categories and pathologists' practice patterns and possible explanatory variables. The diagnoses AUS and SFM were reported in 4060 cases (7.86%) and 1554 cases (3.01%) in the cohort, respectively. The mean rates for these indefinite diagnoses varied up to 3-fold between pathologists. Correlations were found between AUS and SFM, as well as between indefinite diagnoses and negative for malignancy (NFM). No correlations were found between pathologists' years of experience or case volume and the rates of indefinite diagnosis or diagnostic certainty. A real-world baseline for the rates of indefinite diagnoses in pleural effusion cytology is provided in this large retrospective study. Pathologists show significant variation in their use of indefinite diagnostic categories, and the tendency to use these ambiguous terms was not correlated with individuals' experience or case volume. How to untangle the intertwined relationship between the uncertainty of indefinite diagnoses and that of NFM requires future prospective studies.

A distributed multi-objective optimization method for scheduling of integrated electricity and hydrogen systems

The growing diversity in energy demand has led to an increasingly intertwined relationship between the electric power system (EPS) and hydrogen energy system (HES). However, these systems are presently managed by entities with distinct interests, resulting in competition and privacy concerns during the scheduling of integrated electricity and hydrogen systems (IEHSs). To address this issue, this paper proposes a multi-objective IEHS scheduling model with the aim of minimizing costs for electricity and hydrogen suppliers, taking into account bi-directional energy transactions between EPS and HES. Furthermore, we present an innovative approach based on alternating direction multiplier method (ADMM) for distributed ξ-constraint optimization. This approach efficiently captures the optimal Pareto frontier while maintaining the privacy of EPS and HES. The proposed methodology is validated on an IEHS composed of an IEEE 33-bus EPS and a 20-node HES. The results demonstrate that no matter how many solution sets, a more uniform pareto front can be obtained than the traditional method. Furthermore, it simplifies the multi-objective optimization problem and effectively protects the privacy of participants at the expense of acceptable solution time.

How digital technology affects working conditions in globally fragmented production chains: Evidence from Europe

This paper uses a sample of over 9 million workers from 22 European countries to study the intertwined relationship between digital technology, cross-border production links and working conditions. We compare the social consequences of technological change exhibited by three types of innovation: computerisation (software), automation (robots) and artificial intelligence (AI). To fully quantify work-related wellbeing, we propose a new methodology that amends the information on remuneration by reference to such non-monetary factors as the work environment (physical and social), career development prospects, or work intensity. First, we show that employee wellbeing is related to the type of technological exposure. Employees in occupations with a high degree of software or robot exposure face worse working conditions – contrary to highly AI exposed occupations. Thus, we find that AI technologies differ from previous waves of technological progress - also in relation to workers' wellbeing. Additionally, we show that the relationship between digital technology and working conditions weakly depends on participation in global production chains.

Do early symptoms of prolonged grief disorder lead to symptoms of posttraumatic stress disorder and depression? A longitudinal register-based study of the two first years of bereavement.

Symptoms of prolonged grief disorder (PGD), depression, and posttraumatic stress disorder (PTSD) often emerge concurrently in bereavement. The understanding of temporal relationships between these syndromes in a general bereaved population is limited. This study aims to investigate temporal relationships between these syndromes from 2 months postloss throughout the two first years of bereavement. Data were derived from a registry-based cohort study with 1,224 adult participants, who lost a spouse or parent. Participants completed self-report measures of PGD, depression, and PTSD at 2, 6, 11, 18, and 26 months postloss. Random intercept cross-lagged panel analyses examined the temporal relationships between PGD, PTSD, and depression. In spousal and parental bereavement, high levels of grief symptoms at 2 months postloss predicted subsequent high symptoms of PTSD and depression at 6 months postloss, not vice versa. PGD, PTSD, and depression showed strong intertwined relationships over the two first years of bereavement. Between-person differences explained an increasingly large amount of variance in symptoms of PGD, PTSD, and depression over time. Losing a spouse and younger age was associated with higher symptoms of PGD, PTSD, and depression compared to losing a parent and older age. In the early years of bereavement, large differences exist between bereaved individuals in general levels of PGD, PTSD, and depression. Within bereaved individuals, the temporal relationships between these syndromes become increasingly complex and intertwined over time. Findings should be interpreted with respect to the nonclinical sample and self-report data used. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Recognising Indigenous Provenance in Biodiversity Records

The advent of data-driven technologies and the increasing demand for data have brought about unique challenges for Indigenous data governance. The CARE principles emphasize Collective Benefit, Authority, Responsibility, and Ethics as essential pillars for ensuring that Indigenous data rights are upheld, Indigenous knowledge is protected, and Indigenous Peoples are active participants in data governance processes (Carroll et al. 2020, Carroll et al. 2021). Identifying tangible activities and providing guidance to centre Indigenous perspectives provide a comprehensive approach to address the complexities of Indigenous data governance in a rapidly evolving data landscape (Gupta et al. 2023, Jennings et al. 2023, Sterner and Elliott 2023). Biodiversity research has increasingly recognized the intertwined relationship between biological diversity and cultural practices, leading to discussions about how research can strengthen the evidence base, build trust, enhance legitimacy for decision making (Alexander et al. 2021) and explore requirements for Indigenous metadata (Jennings et al. 2023). An Indigenous Metadata Bundle Communique, produced following an Indigenous Metadata Symposium, recommended the initial categories as: Governance, Provenance, Lands & Waters, Protocols, and Local Contexts Notices & Labels. Traditional Knowledge (TK) and Biocultural (BC) Labels have emerged as essential tools for recognising and maintaining Indigenous provenance, protocols and permissions in records for both natural ecosystems and cultural heritage (Anderson et al. 2020, Liggins et al. 2021) emphasizing the importance of Indigenous Peoples and local knowledge systems in research and digital management. Biocultural labels acknowledge the intricate links between biodiversity and cultural diversity, emphasizing the role of indigenous communities in preserving biodiversity through their traditional practices (Hudson et al. 2021). By recognizing the intrinsic value of these relationships, TK and BC labels not only contribute to a more holistic understanding of biodiversity but also promote ethical considerations and mutual respect between researchers and local communities, fostering collaborative partnerships for research and conservation initiatives (McCartney et al. 2023). Addressing the CARE Principles for Indigenous Data Governance in biodiversity research introduces several challenges and opportunities. Ethical concerns regarding recognition of Indigenous rights and interests in data (Hudson et al. 2023), intellectual property rights, cultural appropriation, and equitable benefit sharing, must be navigated sensitively (Carroll et al. 2022b, Golan et al. 2022). Moreover, fostering effective communication between researchers and communities is paramount for ensuring the accuracy and authenticity of Indigenous metadata and protocols for appropriate use (Carroll et al. 2022a). However, these challenges are offset by the potential for enriching scientific knowledge, enhancing policy frameworks, and strengthening community-based conservation efforts.

Governance of artificial intelligence applications in a business audit via a fusion fuzzy multiple rule-based decision-making model

A broad range of companies around the world has welcomed artificial intelligence (AI) technology in daily practices because it provides decision-makers with comprehensive and intuitive messages about their operations and assists them in formulating appropriate strategies without any hysteresis. This research identifies the essential components of AI applications under an internal audit framework and provides an appropriate direction of strategies, which relate to setting up a priority on alternatives with multiple dimensions/criteria involvement that need to further consider the interconnected and intertwined relationships among them so as to reach a suitable judgment. To obtain this goal and inspired by a model ensemble, we introduce an innovative fuzzy multiple rule-based decision making framework that integrates soft computing, fuzzy set theory, and a multi-attribute decision making algorithm. The results display that the order of priority in improvement—(A) AI application strategy, (B) AI governance, (D) the human factor, and (C) data infrastructure and data quality—is based on the magnitude of their impact. This dynamically enhances the implementation of an AI-driven internal audit framework as well as responds to the strong rise of the big data environment.