This paper provides a fresh redemptive reading of Gen 3:16, viewed in light of a whole mosaic of canonical contexts and intertextual connections. These include, among others, the full equality without hierarchy of man and woman in Gen 1–2; the paradigmatic nature of egalitarian marriage with mutual submission between husband and wife in Gen 2:18–24; the rupture of husband–wife relationships in Gen 3:6–13; the covenant lawsuit of Gen 3:14–19; the meaning of mashal in Gen 1:16–18 and 4:7; the meaning of teshuqah and grammatical–syntactical parallels and contrasts in Gen 4:7 and Song 7:11 (Eng. v. 10); the redemptive aspects of the woman and her seed in Gen 3:15; and the intertextual connections with New Testament passages. Considering this mosaic of contexts and connections, it is suggested that Gen 3:16 must be viewed only in reference to marriage; it is never broadened to include man–woman gender relationships in general. In Gen 3:16, God provides a temporary, remedial measure to preserve harmony and unity in a ruptured marriage relationship, with an implicit call for husbands and wives to return as soon as possible from the mashal–teshuqah relationship to the paradigmatic egalitarian marriage set forth in Gen 2:24. This return to the divine creation ideal for marriage is empowered by the redemptive promises of Gen 3:15, confirmed in the reversal of the Gen 3:16 marital relationship articulated in the Song of Songs—the inspired commentary on Gen 1–3—particularly Song 7:11 [Eng. v. 10]), and reaffirmed in the consistent citations of Gen 2:24 (and not Gen 3:16) in the NT (Matt 19:5, 6; Eph 5:31).