ABSTRACTThis article suggests that the developments during the past few decades indicate a qualitative shift in the city/state relation, and conceptualizes this shift as the geopolitical growth of cities and city-regions. Originally a state-orchestrated process, today this is manifested in the attempts of major cities and city-regions, in particular, to demand a stronger national and international political role even as claims are made for urban separatism. This process is connected to a geopolitical reasoning of the heightened role of cities in inter-state competition during the age of post-Fordist capitalism. Furthermore, the geopolitical growth of cities and city-regions is partly constituted in academic theories and expert knowledges that combine certain type of urbanism, economic growth, and political success, and which in so doing destabilize state-centered geopolitical imaginations.