Interpretive Strategies Research Articles

Pulmonary Function Tests: Easy Interpretation in Three Steps.

Pulmonary function tests (PFTs) are pivotal in diagnosing and managing a broad spectrum of respiratory disorders. These tests provide critical insights into lung health, guiding diagnoses, assessing disease severity, and shaping patient management strategies. This review addresses the complexities and nuances inherent in interpreting PFT data, particularly in light of recent updates from the European Respiratory Society (ERS) and American Thoracic Society (ATS). These updates have refined interpretive strategies, moving away from definitive diagnostic uses of spirometry to a more probabilistic approach that better accounts for individual variability through the use of Z-scores and lower limits of normal (LLNs). Significantly, this narrative review delves into the philosophical shift in spirometry interpretation, highlighting the transition from direct clinical diagnostics to a more nuanced evaluation geared towards determining the likelihood of disease. It critiques the reliance on fixed ratios and emphasizes the need for reference values that consider demographic variables such as age, sex, height, and ethnicity, in line with the latest Global Lung Function Initiative (GLI) equations. Despite these advances, challenges remain in ensuring uniformity across different predictive models and reference equations, which can affect the accuracy and consistency of interpretations. This paper proposes a streamlined three-step framework for interpreting PFTs, aiming to unify and simplify the process to enhance clarity and reliability across various medical specialties. This approach not only aids in accurate patient assessments but also mitigates the potential for misdiagnosis and ensures more effective patient management. By synthesizing contemporary guidelines and integrating robust physiological principles, this review fosters a standardized yet flexible approach to PFT interpretation that is both scientifically sound and practically feasible.

Children's Interpretations of Numerically Quantified Expression Ambiguities: Evidence from Quantified Noun Phrases and Bare Cardinals.

Understanding how children comprehend text by forming links between sentences has been the focus of research for decades. Such research has consistently shown that children use anaphors and resolve ambiguities in a different manner than adults. The present study examined a less-studied anaphoric reference that arises when two numerically quantified expressions (e.g., "three cats… two cats…") are used in the text. Focusing on 249 six- to eight-year-old children and 50 adults for comparison, the study employed a picture selection task across six experiments to assess interpretative preferences in ambiguous and unambiguous discourses containing numerically quantified expressions. The findings indicate a pronounced difference in interpretative strategies: unlike adults, who predominantly adopted an anaphoric subset reading, children showed a consistent preference for the non-anaphoric reading, even in contexts explicitly disambiguated towards this interpretation. This preference persisted across various experimental manipulations, highlighting challenges in text integration and comprehension among children. Contributing to the developmental trajectory of language comprehension, this study underscores the complexity of cognitive development and linguistic interpretation, revealing significant developmental differences in processing numerically quantified expressions and anaphoric references within discourse.

Beyond the Text: Comparative Analysis of Paratextual Elements in the Arabic Translations of Toni Morrison’s Paradise

This study investigates the paratextual elements in the Arabic translations of Toni Morrison’s Paradise, focusing on the translations by Tawfiq Al-Asadi and Ali Basha. Paratextual elements, including introductions, book covers, titles, forewords, and footnotes, play a crucial role in shaping reader reception and interpretation, particularly in translated literary works. This study aims to analyze how these elements influence the reception and interpretation of the novel within the Arabic-speaking world. Through a comparison of the visual and semantic interfaces between the source text (ST) and the target texts (TTs), this research reveals how paratextual elements are adapted or transformed to suit the cultural context of the target audience. The analysis encompasses book covers, title translations, forewords, dedications, and footnotes, highlighting the impact of these elements on reader engagement and understanding. The findings suggest that the translators’ choices reflect their cultural, ideological, and gendered perspectives, influencing their interpretative strategies and the final reception of the translated text. These paratextual elements highlight literary translation's obstacles and translators' active participation in crossing cultural and linguistic boundaries.

How about Pantheism in Ancient Greek Religion?

Abstract Ancient Greek religion has been very rarely studied with reference to pantheism. This article proposes that we should introduce pantheism as an additional interpretive strategy to understand Greek religion. This presupposes addressing the relationship between the interpretations of doxa (theology), discussion about the nature of divine unity in antiquity (philosophy), and religious cult praxis. The main conceptual arguments underlined in refutations of pantheism are discussed. This is followed by a brief survey of the more frequently discussed monotheism and henotheism in Greek religion. The main part of the article presents pantheistic trends in Greek religion, including philosophical argumentation, pantheistic expressions in mythology and in cultic life. It is found that Greek religion exhibits views that can be regarded as pantheistic: gods were immanent rather than transcendent, everything could potentially participate in divine reality, and the boundaries between divine, human, and nature were not exclusive but permeable and fluid.

Antwerp's Royal Museum of Fine Arts

AbstractThe Royal Museum of Fine Arts in Antwerp, Belgium, reopened after an 11‐year renovation. In addition to completely cleaning the exterior façade of the neoclassical building, a new, modern wing was built inside former internal courtyards—a glossy, white cube with very high ceilings and a dramatic 100+ step flight of stairs. The historical part of the museum was also fully renovated to its original grandeur. The collection was reinstalled, and the overall interpretive strategy focused on making the art approachable to a multigenerational and multicultural visitorship: Eschewing chronology, paintings are grouped by themes, texts are user‐friendly and encourage interactive experiences, and special activities are available for children. Short videos are also available in some galleries that provide context, explain specific art techniques, or contain games. A wide range of experiences is available to museum users, somewhat consistent with an approach proposed by the Smithsonian Institution's IPOP framework. The reviewer found the reinstallation and related user experiences a relevant, people‐oriented model for 21st century art museums.

Deciphering the association between biopsy-confirmed systemic small vessel vasculitis and Epstein-Barr virus-positive polymorphic B-cell lymphoproliferation.

The Epstein-Barr virus (EBV) is associated with various lymphoproliferative disorders (LPD). Additionally, EBV infection has correlated with diverse autoimmune diseases. However, the association between EBV and systemic small vessel vasculitis (SVV) remains controversial. Here, we report a case of SVV with pauci-immune glomerulonephritis accompanied by an EBV-positive polymorphic B-cell LPD, not otherwise specified. The intricate distinction between EBV-positive B-cell LPD and SVV was difficult, as both diseases demonstrated similar clinical presentations. Lymph node and kidney biopsies facilitated the accurate diagnosis of these two conditions. The administration of high-dose prednisolone, combined with rituximab, proved efficacious, with no instances of relapse over the subsequent 2-year period. This case indicates an association between EBV-positive B-cell LPD and SVV. The diligent execution of biopsies is a crucial diagnostic and interpretive strategy, generating precise comprehension of this condition and guiding its appropriate therapeutic management.

Clinical application of plasma P-tau217 to assess eligibility for amyloid-lowering immunotherapy in memory clinic patients with early Alzheimer's disease.

With the approval of disease-modifying treatments (DMTs) for early Alzheimer's disease (AD), there is an increased need for efficient and non-invasive detection methods for cerebral amyloid-β (Aβ) pathology. Current methods, including positron emission tomography (PET) and cerebrospinal fluid (CSF) analysis, are costly and invasive methods that may limit access to new treatments. Plasma tau phosphorylated at threonine-217 (P-tau217) presents a promising alternative, yet optimal cutoffs for treatment eligibility with DMTs like aducanumab require further investigation. This study evaluates the efficacy of one- and two-cutoff strategies for determining DMT eligibility at the Butler Hospital Memory & Aging Program (MAP). In this retrospective, cross-sectional diagnostic cohort study, we first developed P-tau217 cutoffs using site-specific training data and BioFINDER-2, which were then tested in potential DMT candidates from Butler MAP (total n = 150). ROC analysis was used to calculate the area under the curve (AUC) and accuracy of P-tau217 interpretation strategies, using Aβ-PET/CSF testing as the standard of truth. Potential DMT candidates at Butler MAP (n = 50), primarily diagnosed with mild cognitive impairment (n = 29 [58%]) or mild dementia (21 [42%]), were predominantly Aβ-positive (38 [76%]), and half (25 [50%]) were subsequently treated with aducanumab. Elevated P-tau217 predicted cerebral Aβ positivity in potential DMT candidates (AUC = 0.97 [0.92-1]), with diagnostic accuracy ranging from 0.88 (0.76-0.95, p = 0.028) to 0.96 (0.86-1, p < .001). When using site-specific cutoffs, a subset of DMT candidates (10%) exhibited borderline P-tau217 (between 0.273 and 0.399 pg/mL) that would have potentially required from confirmatory testing. This study, which included participants treated with aducanumab, confirms the utility of one- and two-cutoff strategies for interpreting plasma P-tau217 in assessing DMT eligibility. Using P-tau217 could potentially replace more invasive diagnostic methods, and all aducanumab-treated participants would have been deemed eligible based on P-tau217. However, false positives remain a concern, particularly when applying externally derived cutoffs that exhibited lower specificity which could have led to inappropriate treatment of Aβ-negative participants. Future research should focus on prospective validation of P-tau217 cutoffs to enhance their generalizability and inform standardized treatment decision-making across diverse populations.

Female Characters in Fyodor Dostoevsky’s Novels in Interpretation of Vyacheslav Ivanov

The article analyzes the works of Vyacheslav Ivanov on Fyodor Dostoevsky. Using the material from the book “Dostoevsky: Tragedy — Myth — Mysticism” (1932), the research principles and interpretive strategies implemented by Vyacheslav Ivanov in interpreting the female characters in Dostoevsky’s novels “Crime and Punishment,” “The Devils,” and “The Idiot” are identified. It is shown that Ivanov’s conception of the artistic features of characters such as Sonya Marmeladova, Alena Ivanovna, Maria Timofeevna, and Nastasya Filippovna are revealed in the context of the “main myth” of the works. The mythopoetic and functional aspects are highlighted as the most significant in Ivanov’s interpretations of the female characters. Additionally, it is argued that the psychological and spiritual characteristics of the heroines are not overlooked by the hermeneutist, as understanding the nuances of their inner world was necessary for him to reveal the mythopoetic functions. Through Ivanov’s interpretations of Dostoevsky’s female characters, it becomes evident that the poet-thinker’s approach to the writer’s works represents a synthesis of philosophical conceptualization and historical-literary perspective.

Framework for Ranking Machine Learning Predictions of Limited, Multimodal, and Longitudinal Behavioral Passive Sensing Data: Combining User-Agnostic and Personalized Modeling.

Passive mobile sensing provides opportunities for measuring and monitoring health status in the wild and outside of clinics. However, longitudinal, multimodal mobile sensor data can be small, noisy, and incomplete. This makes processing, modeling, and prediction of these data challenging. The small size of the data set restricts it from being modeled using complex deep learning networks. The current state of the art (SOTA) tackles small sensor data sets following a singular modeling paradigm based on traditional machine learning (ML) algorithms. These opt for either a user-agnostic modeling approach, making the model susceptible to a larger degree of noise, or a personalized approach, where training on individual data alludes to a more limited data set, giving rise to overfitting, therefore, ultimately, having to seek a trade-off by choosing 1 of the 2 modeling approaches to reach predictions. The objective of this study was to filter, rank, and output the best predictions for small, multimodal, longitudinal sensor data using a framework that is designed to tackle data sets that are limited in size (particularly targeting health studies that use passive multimodal sensors) and that combines both user agnostic and personalized approaches, along with a combination of ranking strategies to filter predictions. In this paper, we introduced a novel ranking framework for longitudinal multimodal sensors (FLMS) to address challenges encountered in health studies involving passive multimodal sensors. Using the FLMS, we (1) built a tensor-based aggregation and ranking strategy for final interpretation, (2) processed various combinations of sensor fusions, and (3) balanced user-agnostic and personalized modeling approaches with appropriate cross-validation strategies. The performance of the FLMS was validated with the help of a real data set of adolescents diagnosed with major depressive disorder for the prediction of change in depression in the adolescent participants. Predictions output by the proposed FLMS achieved a 7% increase in accuracy and a 13% increase in recall for the real data set. Experiments with existing SOTA ML algorithms showed an 11% increase in accuracy for the depression data set and how overfitting and sparsity were handled. The FLMS aims to fill the gap that currently exists when modeling passive sensor data with a small number of data points. It achieves this through leveraging both user-agnostic and personalized modeling techniques in tandem with an effective ranking strategy to filter predictions.

For the People

The conservation field has recently experienced a significant paradigm shift called “peoples-based” conservation, which centers collaboration with communities for whom cultural heritage has meaning. This turn is so significant that it has the possibility of upending core preservation practices of dress museology, and yet, few dress studies professionals might be aware that this shift has even occurred, or that it has a name. This article describes the transformative move in conservation ethics towards peoples-based approaches and points to potential impacts this shift might have on the preservation of dress artifacts. One specific fashion museological practice—the prohibition against the wearing of historic dress—is explored as an example of how this shift towards peoples-based conservation approaches opens exciting opportunities for dress professionals, empowering them to consider how collaborative preservation and interpretive strategies might sustain and even enhance the meaning of the collection objects.

More Than Implied: Reading Naja Marie Aidt’s When Death Takes Something from You Give It Back. Carl’s Book

Contemporary autobiographical fiction, especially in Scandinavian literature post-Karl Ove Knausgård, challenges traditional literary interpretation. This article examines interpretive strategies for Naja Marie Aidt’s When Death Takes Something from You Give It Back, advocating for a shift to empathetic, engaged reading, aligning with Rita Felski’s idea of postcritical reading.

Two worlds apart: a qualitative study of culture-led rural regeneration projects in China

ABSTRACT The urban–rural gap remains to be one fundamental inequality in modern China; however, the symbolic boundary derived from such socioeconomic inequality is less examined. Centre on two parallel initiatives aimed at cultural empowerment for rural China—independent bookstores and public-subsidized libraries—this study tries to explicate the multidimensional nature of boundaries and emphasize the cultural mechanism of boundary reproduction under institutional layering environment. We draw from policy trajectories, media discourse, and first-hand interviews in two villages, and reveal that despite the idealized portrayal of bookstores as a public cultural centre for empowerment, the symbolic construction wielded by cultural entrepreneurs is not sufficient in dissolving social differences in a digitalized society. Local villagers are not part of the “cultural consumption as identity building” ritual therefore being excluded from an urban-and-consumption culture-oriented space. Moreover, local villagers adopt differentiated interpretive strategies towards culture-led regeneration projects, so that “rural culture” is merely the swirl of an empty signal in Baudrillard’s sense that does not bear the symbolic efficacy promoted by top-down initiatives.

Queering a Trans Life Story: The Unnatural Potential of Weak Narrativity in succubus in my pocket

ABSTRACT: Discussing similarities between antimimetic and queer/trans narratives, as well as interlacing subjects of interest in the respective fields of unnatural and queer/trans narratology, this article suggests the importance of experimental texts for theorizing trans narratives. It presents its arguments by focusing on one case study, a mixed genre manuscript written in 2004 and published in 2015, succubus in my pocket by the late trans poet kari edwards (1954–2006). My approach mines queer narratology (Susan Lanser), trans poetics (Trace Peterson), unnatural narratology (Brian Richardson), and the study of narrative poetry (Brian McHale) for conceptual tools to discuss how an extremely antimimetic narrative entwines transgressions of narrative expectations with transgressions of expectations about sex and gender. The work invites narrative interpretations of sequential events based on causal expectations while consistently refuting default interpretive strategies. This article shows how weak narrativity can be deployed as a critique of narrative sense-making processes in general and, more particularly, of conventional progression in narratives about trans lives.

History Reclaimed: Strategies of Reading and Interpretation in New Historicism

#يتناول هذا البحث ظهور وأهمية المنهج التاريخي الجديد كاستجابة للنهج القائم على النص المتبع من قِبل المستشرقين والنقاد الجدد. يسلط المنهج التاريخي الجديد الضوء على الاعتبارات التاريخية في تحليل النصوص الأدبية ويؤكد على القراءة المتوازية للنصوص الأدبية وغير الأدبية من نفس الفترة الزمنية. يعتبر المنهج التاريخي الجديد هذه النصوص مكونات للخطابات التاريخية ويستكشف الروابط بين النصوص والخطابات والسلطة وتشكيل الفرد. يمكن اعتبار انتشار المنهج التاريخي الجديد تطوراً طبيعياً بعد تراجع النقد الجديد وسطوة ما بعد الهيكلية. يُعتبر ستيفن غرينبلات، أستاذ اللغة الإنجليزية البارز في جامعة بيركلي، الأب المؤسس للمنهج التاريخي الجديد. قد ابتكر مصطلح "المنهج التاريخي الجديد" لوصف طريقته في تفسير النصوص النهضوية والنهج الذي اعتمده الكتاب الآخرون في هذا المجال. ومع ذلك، يفضل غرينبلات بنفسه مصطلح "الشعرية الثقافية" عوضًا عن المنهج التاريخي الجديد. يتناول المقال أيضًا تمييز غرينبلات بين الدهشة والرنين، حيث يُعتبر الرنين المفهوم المفضل المرتبط بالاهتزاز الثقافي وأهمية النص. على الرغم من تعليقات بعض النقاد بشأن انحسار الأدب أمام التاريخ أو عدم وجود نظرية تاريخية أو أن التركيز على ربط الأدب بالسياسة يشبه النقد "الكلب الجيد/الكلب السيء" حيث يمدح النقاد الكتاب لآرائهم التقدمية وينتقدونهم لآرائهم المتحجرة، فإن المنهج التاريخي الجديد لا يزال تطورًا مهمًا في دراسات الأدب ويوفر بديلًا للنهج ما بعد الهيكلية.

Approaches to textual sources in cultural history

ABSTRACT How do we approach textual sources within cultural history? Do we ‘think’ about sources and ‘work’ with them in similar ways? Is it possible to identify a specific methodology among cultural historians? Cultural history is both a subfield and a discipline in its own right. In this domain, scholars often equate methodology with the application of theories to a text. However, it is crucial to explore the gap between reading a textual source and applying theories to understand and interpret it. This need to address methodology in a didactic manner motivates this special issue. Rather than taking our interpretive methods for granted, the authors in this special issue advocate for a self-reflective consciousness, explaining what we do and why. Through investigations and discussions on how we define and categorize textual sources within cultural history, the reading strategies we apply when approaching texts, and the interpretive strategies we may employ, the articles in this issue illustrate the relationship between application and result: how our methodology impacts our findings.

Recommendations for the reporting and interpretation of isotope dilution U-Pb geochronological information

U-Pb geochronology by isotope dilution−thermal ionization mass spectrometry (ID-TIMS) has the potential to be the most precise and accurate of the deep time chronometers, especially when applied to high-U minerals such as zircon. Continued analytical improvements have made this technique capable of regularly achieving better than 0.1% precision and accuracy of dates from commonly occurring high-U minerals across a wide range of geological ages and settings. To help maximize the long-term utility of published results, we present and discuss some recommendations for reporting ID-TIMS U-Pb geochronological data and associated metadata in accordance with accepted principles of data management. Further, given that the accuracy of reported ages typically depends on the interpretation applied to a set of individual dates, we discuss strategies for data interpretation. We anticipate that this paper will serve as an instructive guide for geologists who are publishing ID-TIMS U-Pb data, for laboratories generating the data, the wider geoscience community who use such data, and also editors of journals who wish to be informed about community standards. Combined, our recommendations should increase the utility, veracity, versatility, and “half-life” of ID-TIMS U-Pb geochronological data.

Assessing heterogeneous groundwater systems: Geostatistical interpretation of well logging data for estimating essential hydrogeological parameters

This research presents an unsupervised learning approach for interpreting well-log data to characterize the hydrostratigraphical units within the Quaternary aquifer system in Debrecen area, Eastern Hungary. The study applied factor analysis (FA) to extract factor logs from spontaneous potential (SP), natural gamma ray (NGR), and resistivity (RS) logs and correlate it to the petrophysical and hydrogeological parameters of shale volume and hydraulic conductivity. This research indicated a significant exponential relationship between the shale volume and the scaled first factor derived through factor analysis. As a result, a universal FA-based equation for shale volume estimation is derived that shows a close agreement with the deterministic shale volume estimation. Furthermore, the first scaled factor is correlated to the decimal logarithm of hydraulic conductivity estimated with the Csókás method. Csókás method is modified from the Kozeny-Carman equation that continuously estimates the hydraulic conductivity. FA and Csókás method-based estimations showed high similarity with a correlation coefficient of 0.84. The use of factor analysis provided a new strategy for geophysical well-logs interpretation that bridges the gap between traditional and data-driven machine learning techniques. This approach is beneficial in characterizing heterogeneous aquifer systems for successful groundwater resource development.

Spanish–English bilingual heritage speakers processing of inanimate sentences

This study investigated how heritage Spanish–English bilinguals integrate their cue hierarchies to process simple sentences in both Spanish and English. Sentence interpretation is achieved by weighing the various cues that are present in the sentence against that language's cue hierarchy. The Unified Competition Model (UCM) suggests that bilinguals show a variety of patterns in sentence interpretation strategies depending on language proficiency. Previous research on heritage Spanish–English bilinguals and late bilinguals has demonstrated differences in cue utilization and sentence interpretation compared to monolinguals. However, good-enough processing suggests that when a sentence does not meet certain heuristics, like the first-noun agent heuristic, a semantic representation of the sentence will be processed instead of a syntactic one. Even with reliable sentential-level cues such as word order, a plausible semantic representation of the sentence is favored. This is especially the case with inanimate–inanimate (IA-IA) sentences, like in the present study, in which there is less reversibility of thematic roles without competing with semantic plausibility. For this study, participants (n = 32) read a total of 80 inanimate sentences in English and Spanish with subject–verb–object and object–verb–subject (OVS) word orders, indicated the subject of the sentences, and completed language proficiency and dominance tasks. When reading Spanish sentences, participants read the OVS word order faster. English proficiency was a significant predictor of sentence reading time and choice selection time but did not predict word choice. The results suggest that IA-IA sentences pose challenges for cue utilization and thematic role assignment due to semantic limitations. This study found that participants may prioritize semantic plausibility over syntactic representations in sentence processing, supporting a good-enough processing model.

Changes in Spirometry Interpretative Strategies: Implications for Classifying COPD and Predicting Exacerbations

Recent guidelines for spirometry interpretation recommend both race-neutral reference equations and use of z score thresholds to define severity of airflow obstruction. How does the transition from race-specific to race-neutral equations impact severity classifications for patients with COPD when using %predicted vsz score thresholds, and do changes in severity correspond to clinical risk? This retrospective cohort study included Black and White patients with COPD and available spirometry from the Johns Hopkins Health System. Global Lung Function Initiative (GLI) 2012 (race-specific) equations and GLI Global (race-neutral) equations were used to determine FEV1 %predicted and z score values. Patients were classified as having mild, moderate, or severe disease according to %predicted or z score thresholds. Associations between a change in severity classification from race-specific to race-neutral with COPD exacerbations and all-cause hospitalizations were evaluated using logistic regression. This cohort included 13,324 patients, of whom 9,232 patients (69.3%) were White (mean age, 65.7 years) and 4,092 patients (30.7%) were Black (mean age, 61.1 years). More Black than White patients showed a change in severity classification between approaches when using %predicted thresholds (20.2%vs6.1%; P< .001), but not with z score thresholds (12.6%vs12.3%; P= .68). An increased severity classification with a race-neutral approach was associated with increased risk of exacerbation when using z score thresholds (OR, 2.34; 95%CI, 1.51-3.63), but not when using %predicted thresholds (OR, 1.08; 95%CI, 0.61-1.93). A decreased severity classification with a race-neutral approach was associated with lower risk of exacerbation with both %predicted (OR, 0.49; 95%CI, 0.28-0.87) and z score (OR 0.67; 95%CI, 0.50-0.90) thresholds. The proportions of Black and White individuals reclassified were similar with z score thresholds, and changes in severity corresponded to clinical risk with z scores. These results support recent recommendations for use of race-neutral equations and z score thresholds for spirometry interpretation.

Abstract 6615: Reduced penetrance BRCA1 and BRCA2 pathogenic variants in clinical germline genetic testing

Abstract Despite the current binary clinical classification of variants (pathogenic versus benign), it is widely recognized that risk is a continuum. Prior studies have suggested the existence of reduced penetrance pathogenic variants (RPPVs), which pose challenges for identification, reporting, patient counseling and care. Through the current study, we sought to establish RPPVs as a new category of variants, with efforts focused specifically on BRCA1 and BRCA2 (BRCA). We compiled, compared, and assessed data for BRCA RPPVs from two large clinical diagnostic laboratories to establish an initial set of reduced penetrance pathogenic variants. Specifically, candidate BRCA RPPVs provided by clinical diagnostic laboratories were compiled to identify those with the highest prior likelihood of being a RPPV, based on concordant interpretations. Evidence of reduced penetrance included: 1) the identification of biallelic Fanconi Anemia-affected carriers; 2) splicing, missense, and nonsense-mediated RNA decay (NMD)-escaping variants; 3) laboratory-validated cancer history weighting models; 4) published variant-specific risk estimation data; 5) extrapolation of a reduced-risk interpretation onto close match variants that are expected to have the same effect; and 6) functional data. Sixteen candidate BRCA RPPV present in both lists from both laboratories were systematically assessed. For BRCA1, variants included c.5096G&amp;gt;A p.(Arg1699Gln) and variants impacting the canonical c.671 splice acceptor site. For BRCA2, variants included three frameshift (c.658_658delGT, c.9672dupA, c.9699_9702delTATG), two spliceogenic (c.8488-1G&amp;gt;A and c.8488-1G&amp;gt;T), and three missense (c.7878G&amp;gt;C, T, p.(Trp2626Cys); and c.9302T&amp;gt;G p.(Leu3101Arg)) variants. Our study is the first to clearly evaluate and establish BRCA RPPVs as a new class of variants, based on consistency in results across 16 variants using different interpretation strategies between laboratories. These variants impart a moderately increased risk of breast cancer, often considered to be between 2-4 fold, which should be considered when determining risk-informed cancer prevention strategies. Furthermore, our study establishes a framework to harmonize interpretation and standardize reporting of BRCA RPPV, by providing evidence to support this new classification for 16 variants. Further work to define clinically meaningful risk thresholds and categories for reporting BRCA RPPV are needed to personalize cancer risks in conjunction with other risk factors. Citation Format: Tuya Pal, Erin Mundt, Marcy Richardson, Elizabeth Chao, Tina Pesaran, Thomas P. Slavin, Fergus Couch, Alvaro N. Monteiro. Reduced penetrance BRCA1 and BRCA2 pathogenic variants in clinical germline genetic testing [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 6615.