<p indent="0mm">The Nobel Prize in Physics 2022 was awarded to three experiment physicists: Alain Aspect, John F. Clauser and Anton Zeilinger, for their contributions to “experiments with entangled photons, establishing the violation of Bell inequalities and pioneering quantum information science”. In this paper, the history, basics, and applications related with the Bell inequalities are reviewed. The discussion of fundamental issues on quantum mechanics dated back to the year 1927 when the fifth Solvay conference was held, highlighting intense arguments between Albert Einstein and Niels Bohr. At the time, Einstein expressed, publicly for the first time, his critical attitude towards quantum mechanics. While the arguments did not reach a decisive conclusion, Bohr’s probabilistic interpretation of quantum mechanics, the Copenhagen interpretation, had since been well circulated among the community. Einstein’s arguments with Bohr lasted many years after the conference. The arguably most famous one was the Einstein-Podolsky-Rosen (EPR) paradox, proposed in a 1935 paper written by the three authors. They stated, by flawless reasoning, that quantum mechanics is ‘incomplete’. Bohr replied immediately. So did Erwin Schrödinger, who, in particular, coined the term ‘entangled’ for the first time to describe the bizarre quantum mechanical property. Nevertheless, the EPR paper received few citations at its publication, until 1990’s when quantum information science started blossoming. From today’s perspective, the paper resembles the ‘sleeping beauty’ who slumbered for decades before fully awakening. It has been widely accepted that it was John S. Bell who eventually resolved the EPR paradox. But many important figures before him should not go unnoticed, including John A. Wheeler, Chien-Shiung Wu, David Bohm, to name a few. In 1964, Bell wrote down a mathematical inequality which satisfies local hidden variable theory but which can be violated in quantum mechanics. The significance is that Bell’s inequality brings the rather philosophic debates on the EPR paradox down to be experimentally testable. Hence, an experiment is here appealing, as is the case in all fields of physics. To the end, John F. Clauser, alongside Stuart J. Freedman, conducted an experiment in 1972 to test a Bell inequality, the Bell-Clauser-Horne-Shimony-Holt (CHSH) inequality, proposed by him and his collaborators in 1969. The results, however, leaves loopholes open. One of the loopholes was closed in a later experiment led by Alain Aspect in 1982. The Bell-CHSH inequality was later tested under a much stricter condition by Anton Zeilinger’s team. Two most important loopholes were both closed by three teams in 2015 independently. Zeilinger’s team was among them. Almost all experiments to date have confirmed quantum mechanical predictions. Zeilinger’s team also performed the first teleportation of unknown quantum states, the first entanglement swapping, along with other contributions pioneering the quantum information science. In retrospect, the foundational study of quantum theory has been developed over a century. It once drew much of quantum physics founders’ attention, went virtually unnoticed while other physical fields advanced, had for quite a while been considered to have very weak relationship with major physics, and finally revived in recent decades leading to rapid progress in quantum information science and quantum technology. We believe that the Nobel Prize in Physics this year is not only an award and recognition to past achievements, but also heralds a new era of science in future.