Interpersonal Variables Research Articles

Neuromorphic computing with hybrid CNN–Stochastic Reservoir for time series WiFi based human activity recognition

Wi-Fi Channel State Information (CSI) based human activity recognition (HAR) which using channel disturbances caused by signal reflection is a novel way of environment sensing and motion recognition. The collected channels characteristics are heavily influenced by the environment, human activity patterns and subject’s weight and height. These signal variations reflected from body components are mainly affected by static multipath effects comprises random noise and behave differently in individuals, and thus an active field of research. To reach further for achieving automated real-time classification, lower computational cost and easy adaptability to hardware are necessary. In this work, a CSI-based HAR with hybrid framework, Convolutional Neural Network (CNN)-Stochastic Reservoir (SR) (CNN-SR) has been proposed, enabling a subject adaptable and more efficient hardware implementation with minimal computational complexity. A subcarrier correlation matrix is first computed and portrayed in image without preprocessing based on the reflection of the raw CSI signal induced by human activities at regular intervals, allowing visual observation of whole pattern changes. The time-based features are subsequently extracted through CNN and these feature arrays are then feed into SR which based on stochastic spiking neural network (SSNN) in simple cycle reservoir architecture for template matching. SR offers attractive power savings over typical von Neumann systems, by doing stochastic computations. The proposed method has also been demonstrated that is capable for HAR based on partially captured signals. The signal pattern of each segment can be observed in a single sight and then employed for person-to-person template recognition. This enables HAR with minimal computational complexity and solving the inter-person variability concerns. The results demonstrate that the proposed CNN-SR achieves impressive performance in recognizing human activities and surpasses existing models with an average accuracy of 93.49%.

Identifying human mobility patterns using smart card data

ABSTRACT Human mobility is subject to collective dynamics that are the outcome of numerous individual choices. Smart card data which originated as a means of facilitating automated fare collection has emerged as an invaluable source for analysing mobility patterns. A variety of clustering and segmentation techniques has been adopted and adapted for applications ranging from market segmentation to the analysis of urban activity locations. In this paper we provide a systematic review of the state-of-the-art on clustering public transport users based on their temporal or spatial-temporal characteristics as well as studies that use the latter to characterise individual stations, lines or urban areas. Furthermore, a critical review of the literature reveals an important distinction between studies focusing on the intra-personal variability of travel patterns versus those concerned with the inter-personal variability of travel patterns. We synthesise the key analysis approaches as well as substantive findings and subsequently identify common trends and shortcomings and outline related directions for further research.

Mathematical Psychiatry: On Cortical Spreading Depression-A Review.

The concept of migraine with aura (MwA) is a widespread condition that can affect up to 30% of migraine patients and manifests itself as a temporary visual illusion followed by a prolonged headache. It was initially pitched as a neurological disease, and observed that the spread of accompanying electrophysiological waves as part of the condition, which came to be known as cortical spreading depression (CSD). A strong theoretical basis for a link between MwA and CSD has eventually led to knowledge of the dynamics between the pair. In addition to experiment-based observations, mathematical models make an important contribution towards a numerical means of expressing codependent neural-scale manifestations. This provides alternate means of understanding and observing the phenomena while helping to visualize the links between the variables and their magnitude in contributing towards the emanation and dynamic pulsing of the condition. A number of biophysical mechanisms are believed to contribute to the MwA-CSD, spanning ion diffusion, ionic currents of membranes, osmosis, spatial buffering, neurotransmission, gap junctions, metabolic pumping, and synapse connections. As part of this review study, the various mathematical models for the description of the condition are expressed, reviewed, and contrasted, all of which vary in their depth, perspective, and level of information presented. Subsequent to this, the review looked into links between electrophysiological data-driven manifestations from measurements such as EEG and fMRI. While concluding remarks forged a structured pathway in the area on sub-themes that need to be investigated in order to strengthen and robustify the existing models, they include an accounting for inter-personal variability in models, sex and hormonal factors, and age groups, i.e., pediatrics vs. adults.

Burnout Among Special Education Teachers and the Role of Individual, Interpersonal, and Organizational Risk and Protective Factors

Burnout is a syndrome commonly characterized by the three dimensions of Maslach and Leiter's model, namely emotional exhaustion, depersonalization, and lack of professional accomplishment. While burnout affects individuals in all professions, teachers are recognized as being at particular risk, a fact explained in the literature by the high level of relational demands inherent to the profession. During the pandemic and subsequently, these demands have even increased. Several studies have focused on the influence of individual, interpersonal, and organizational factors predicting teacher burnout risk. Yet, less is known about special education teachers working in inclusive and non-inclusive settings and how the pandemic has particularly affected their burnout risk. Thus, this study aimed to examine (1) whether burnout risk among special education teachers has increased since the pandemic and (2) whether burnout risk is related to individual, interpersonal, and organizational variables, including factors related to the pandemic. For this purpose, a cross-sectional study was conducted among a sample of special education teachers in Switzerland (<em>n </em>= 358) using the Maslach Burnout Inventory. Since there are three distinctive dimensions of burnout, which might also be differently associated with risk and protective factors, we conducted separate logistic regression analyses to predict risk status for emotional exhaustion, depersonalization, and personal accomplishment by individual, interpersonal, and organizational variables. Results indicate that for emotional exhaustion, individual teaching satisfaction and health problems are most important, whereas for depersonalization individual teaching satisfaction, good relationships with parents and working in an inclusive setting decrease burnout risk. An inclusive setting increases the risk, regarding lack of personal accomplishment, while all other effects are non-significant. Implications for practice are discussed.

Variables Associated with Ultra-Processed Foods Consumption among Brazilian Adolescents: A Systematic Review

Background: Considering its deleterious effects on health, as well as the importance of information to support actions, strategies, and public policies, the present study was developed, aiming at identifying and classifying the main variables associated with ultra-processed foods consumption in Brazilian adolescents. Data sources: Targeting observational studies involving samples of Brazilian adolescents (11 to 19 years old), which evaluated possible associations between the consumption of ultra-processed foods and individual, interpersonal, environmental, and public policy variables, in October 2022, a systematic review was conducted, consulting electronic databases (Lilacs, Pubmed, Scielo, Scopus, and Web of Science), Google Scholar, and the reference lists of included articles. Data synthesis: The descriptive synthesis consisted of 11 papers, representing nine original studies. The main variables identified were: sedentary behavior (specially screen time), studying at a private school, having a higher body mass index, and being female. Conclusions: Based on this evidence, it is important to direct actions, strategies, and public policies aimed at confronting the consumption of ultra-processed foods for these groups.

A frequent CYP2D6 variant promotes skipping of exon 3 and reduces CYP2D6 protein expression in human liver samples.

CYP2D6 is one of the most polymorphic drug-metabolizing enzymes in the liver. While genetic CYP2D6 variants serve as clinical biomarkers to predict CYP2D6 activity, large inter-person variability in CYP2D6 expression remains unaccounted for. Previous results suggest that there is variable expression of a CYP2D6 splice isoform with an in-frame deletion of exon 3 (CYP2D6ΔE3) encoding a protein lacking numerous active site residues. Here, using fragment analysis and RT-qPCR, we revealed that rs1058164G (MAF = 27%-43%) is associated with increased formation of CYP2D6∆E3 in human liver samples (1.4-2.5-fold) and transfected cells. Furthermore, western blots showed that rs1058164G was associated with a 50% decrease in full-length hepatic CYP2D6 protein expression. In addition, by studying a larger liver cohort, we confirmed our previous results that rs16947 (CYP2D6*2) reduces full-length CYP2D6 mRNA by increasing the production of an unstable splice isoform lacking exon 6 (CYP2D6ΔE6) and that the impact of CYP2D6ΔE6 is offset in carriers of the downstream enhancer variant rs5758550. The three frequent SNPs (rs1058164, rs16947, and rs5758550) form various 3-SNP-haplotypes, each with distinct CYP2D6 expression characteristics. Using an expression score (ES) system, we tested the impact of the 3-SNP-haplotype on improving the standard model to predict hepatic CYP2D6 protein expression based on genotype. A model that incorporates the 3-SNP-haplotype provided the best fit for CYP2D6 expression and also accounted for more variability in CYP2D6 protein levels (59%) than a model based on the accepted standard (36%) or one that only adds rs16947 and rs5758550 (42%). Clinical studies are needed to determine whether including the 3-SNP-haplotype alongside current standard CYP2D6 models improves the predictive value of CYP2D6 panels.

Doing More with Less on Intracranial Pressure Monitoring

Intracranial pressure (ICP) management based on predetermined thresholds is not accurate in light of recent research on cerebrovascular physiology. Interpersonal and intrapersonal variations will lead ICP elevations to reach individualized thresholds for intracranial compliance impairment from one subject to another. Therefore reuniting the modern techniques of neuromonitoring besides ICP enables practitioners to have a more whole picture in anticipating neuro worsening and improving timing in decision making. Brief literature review. For the severely brain-injured patient, current evidence indicates a personalized and physiology-based multimodal monitoring care to be required rather than decision making according to ICP predetermined cut-offs. The authors' point of view is of particular importance for regions with resource heterogeneity and scarcity, where ICP monitoring is not available for all those in need and noninvasive techniques may provide a surrogate approach. If physicians who deal with acute-brain-injured patients in lower-resource areas understand that several tools besides ICP may improve their practice, it is possible to reduce acute brain injury morbimortality.

The Influence Of Agricultural Extension Communication Forms On The Adoption Rate Of Post-Harvest Rice Technology Innovation

This study was conducted to determine (1) the influence of forms of interpersonal communication, group communication and mass communication carried out by agricultural extension services on the adoption rate of postharvest rice field technology innovations. (2) To find out the right form of agricultural extension communication in order to achieve the adoption of pascpapanen technological innovations. This research was conducted in Gapoktan Mulya Jaya in Babakanmulya Village, Jalaksana District, Kuningan Regency. The study was conducted from September to October 2022. This method and type of research uses descriptive quantitative methods with survey techniques and a sample of 75 members of the Association. Technical data collection is primary data obtained from interviews and questionnaires, and secondary data obtained from data obtained from literature studies and data from agencies or institutions related to research. Data Analysis techniques performed include: descriptive analysis, multiple linear regression analysis, and F test. The results of multiple linear regression analysis (1) Interpersonal Communication Variables have a real effect on the adoption rate of postharvest technology innovations in rice fields, with the results of multiple linear regression tests that have a sig value = 0.001 which means 0.001 < 0.05 and have a B value = 0.791. (2) Group communication variables have a significant effect on the adoption rate of postharvest technology innovations in rice fields, with multiple linear regression test results that have a sig value = 0.038 which means 0.038 < 0.05 and have a value of B – 0.510. (3) Mass Communication Variables have a real effect on the adoption rate of postharvest technology innovations in rice fields, with regression test results that have a GIS value = 0.002 which means 0.002 < 0.05 and has a value of 0.977. (4) The variables of interpersonal communication, group communication, and mass communication have a significant effect on the adoption rate of rice postharvest technology innovations with the results of multiple linear regression equation analysis, namely: Y = (-1.031) + 0.791 + 0.510 + 0.977 X_1 X_2 X_3.

Examining Predictors of Depression and Anxiety Symptom Change in Cognitive Behavioral Immersion: Observational Study

Background Depressive and anxiety disorders are the most common mental disorders, and there is a critical need for effective, affordable, and accessible interventions. Cognitive Behavioral Immersion (CBI) is a novel group-based cognitive behavioral skills training program delivered by lay coaches in the metaverse that can be accessed through various modalities including virtual reality (VR) head-mounted displays or flat-screen devices. Combining its ability to offer empirically supported therapy skills in a digital setting that can still facilitate interpersonal variables (eg, working alliance and sense of social support) with the aid of lay coaches, CBI has the potential to help fill this critical need. Objective This study had 2 primary aims. First, we aimed to examine changes in depression and anxiety symptoms in a sample of individuals who participated in CBI. Second, we aimed to examine 2 interpersonal process variables (working alliance and web-based social support) as predictors of symptom changes. We predicted CBI participants would experience depression and anxiety symptom improvements and that such improvements would be associated with an increase in both interpersonal process variables. Methods The study sample consists of 127 participants who endorsed clinical levels of depression or anxiety symptoms during their first CBI session and attended at least 2 sessions. Participants were asked to complete self-report measures of depression symptoms, anxiety symptoms, alliance, and web-based social support throughout their participation in CBI. Results Repeated measures ANOVAs determined that depression and anxiety symptom scores differed significantly across sessions (Ps<.01). We also found participants’ web-based social support predicted improvement in depression symptoms (P=.01), but neither the alliance nor web-based social support predicted change in anxiety symptoms (Ps>.05). We also observed a significant difference in anxiety symptoms between participants who used a VR head-mounted display to access CBI and those who did not, such that participants who used VR head-mounted displays endorsed lower anxiety symptoms than those who did not at nearly every session (P=.04). Conclusions Participation in CBI is associated with both depression and anxiety symptom improvement. Web-based social support may play an important role in fostering changes in depression symptoms. Future studies are encouraged to continue examining the process of change in CBI with special attention paid to methods that can elucidate causal mechanisms of change.

Interpersonal facilitators of complicated grief and depression in the aftermath of suicide loss: The mediated roles of suicide-related shame and guilt.

Suicide-loss survivors (SLSs) are recognized as an at-risk population for several mental health complications, including complicated grief (CG) and depression. Recent studies have emphasized the contribution of interpersonal factors as well as suicide-related shame and guilt as facilitators of CG and depression among SLSs. In this 6 year longitudinal design study, we examined interpersonal variables as predictors of CG and depression, with suicide-related guilt and shame as mediators. Participants were 152 SLSs aged 18-70 who completed questionnaires assessing thwarted belongingness, self-disclosure, and social support at index measurement (T1); suicide-related shame and guilt and CG and depression were assessed 6 years later (T2). The integrated model revealed that the interpersonal factors of social support and self-disclosure at T1 significantly and negatively predict CG and depression (respectively) at T2. Thwarted belongingness was found to significantly and positively predict both CG and depression through the mediation of suicide-related shame levels. The findings highlight the critical role of interpersonal factors in facilitating CG and depression among SLSs. Theoretical implications relating to healing processes are discussed, as well as focused clinical recommendations, including psychoeducational interventions for addressing interpersonal difficulties and suicide-related shame in the aftermath of suicide loss.

Communication Competency: The Impact of Interpersonal Communication on Student's Learning Activities

Interpersonal communication involves communicators and communicants meeting face to face and allows each communicator to capture the communicator's reaction or vice versa directly, both verbally and nonverbally. Good interpersonal communication will help increase student learning activities to the fullest. This study uses a quantitative approach with a survey method. The population in this study was 113, and the sample was 66, obtained using the proportional random sampling technique. The research was conducted at the Jinarakkhita Buddhist College of Religion in Lampung with even semester student respondents. Based on the study's results, it illustrates a significant influence between interpersonal communication variables and student learning activity variables. The criterion for testing the hypothesis is to reject H0 if t count > t table and vice versa. For the t distribution used dk = (n-2) and a = 0.05. Based on the data analysis obtained tcount = 3,081 while the t table with n = 66 and a = 0.05 brought 1,668. Then it can be seen that t count> t table (3,081> 1.668) or sig (0.003≤0.05), it is concluded that H0 is rejected and Ha is accepted, so there is an influence interpersonal communication on student learning activities.

A wireless patch for the monitoring of C-reactive protein in sweat.

The quantification of protein biomarkers in blood at picomolar-level sensitivity requires labour-intensive incubation and washing steps. Sensing proteins in sweat, which would allow for point-of-care monitoring, is hindered by the typically large interpersonal and intrapersonal variations in its composition. Here we report the design and performance of a wearable and wireless patch for the real-time electrochemical detection of the inflammatory biomarker C-reactive (CRP) protein in sweat. The device integrates iontophoretic sweat extraction, microfluidic channels for sweat sampling and for reagent routing and replacement, and a graphene-based sensor array for quantifying CRP (via an electrode functionalized with anti-CRP capture antibodies-conjugated gold nanoparticles), ionic strength, pH and temperature for the real-time calibration of the CRP sensor. In patients with chronic obstructive pulmonary disease, with active or past infections or who had heart failure, the elevated concentrations of CRP measured via the patch correlated well with the protein's levels in serum. Wearable biosensors for the real-time sensitive analysis of inflammatory proteins in sweat may facilitate the management of chronic diseases.

P-077 The clues underneath the purple head: sperm fragmentation correlation with seminal quality parameters after swim-up techniques and sperm cryopreservation

Abstract Study question Does the culture media and the protocols used for sperm processing and cryopreservation significantly affect DNA integrity? How does it correlate to other sperm parameters? Summary answer In one of the analyzed media, the DNA damage was significantly higher after swim-up. DNA integrity is negatively correlated with concentration, vitality and motility. What is known already DNA fragmentation index (DFI) has proven to be a valuable tool in the diagnosis of infertility since men evaluated as normozoospermic in the seminogram may have high levels of sperm DNA fragmentation.There is already evidence of sperm DNA fragmentation affecting fertility, though the use of this information in ART is limited. The study of DNA fragmentation is relevant in fresh samples but also in processed and/or cryopreserved samples, since these procedures are likely to alter the sperm DNA integrity and change the treatment’s outcome. Extended culture times, media composition or even the performed protocol may induce those changes. Study design, size, duration The sperm sample collection was performed at CETI (Porto, Portugal) for 4 years. During this time, 207 seminogram samples were evaluated for DNA integrity using the Toluidine Blue test (TB) and Pearson’s correlation was applied. From that pool, 30 samples were selected to evaluate the impact of time and media used for swim-up protocols. Other 30 samples were analyzed for comparison after cryopreservation with two different media. In both cases an ANOVA test was applied. Participants/materials, setting, methods Men aged between 17 to 62 years old, collected a sperm sample for seminogram analysis according to the WHO and ESHRE criteria. After their informed consent was given, the same sample was used to test three different culture media. Swim-up technique was applied and the upper portion was removed for motility, concentration and DFI evaluation. Additionally, two distinct cryoprotectants (glycerol or egg yolk) were compared for sperm motility and DNA integrity before and after cryopreservation. Main results and the role of chance In this study, DNA integrity was evaluated using TB staining, a simple and affordable method for indirect assessment of DFI. DNA integrity was negatively correlated (p < 0.0001) with concentration (r= -0.301), vitality (r= -0.421), morphology (r= -0.278) and total motility (r= -0.280). Moreover, normozoospermic samples showed higher DNA integrity than samples with at least one impaired parameter (p < 0.0001). ROC curve analysis was used to establish a diagnostic threshold, above which samples are potentially damaged and consequently may lead to infertility situations. This value is around 21%, which could be an advance for the clinical application of this method, making the evaluation of DFI fair to all ART laboratories. Also, it was found that the incubation at room temperature may be beneficial since it improved sperm motility after 1h and 2h (respectively p = 0,0016 and p = 0,0130) compared to incubation at 37ºC with the same medium. All media recorded an increase in DNA damage over time. There were no significant statistical differences between cryopreservation media. However, the results suggest that the medium with egg yolk cryoprotectant may promote greater stability and membrane fluidity, decreasing the impact on sperm motility and DNA damage caused by the cryopreservation process. Limitations, reasons for caution These results should be taken with caution and, in order to strengthen them, additional samples should be analyzed. Also, the correlation between different sperm parameters is based on comparisons between several individuals who exhibit some interpersonal variability and was based on traditional semen analysis, which is slightly subjective. Wider implications of the findings The establishment of a threshold for DFI may be useful for daily practice. We observed that media rich in aminoacids and proteins promote sperm motility after swim-up and that room-temperature incubation is also beneficial. We concluded that media with egg yolk may promote greater sperm motility and less DNA damage. Trial registration number Not applicable

Dietary Patterns, Gut Microbiota Remodeling, and Cardiometabolic Disease.

The cardiovascular and metabolic disorders, collectively known as cardiometabolic disease (CMD), are high morbidity and mortality pathologies associated with lower quality of life and increasing health-care costs. The influence of the gut microbiota (GM) in dictating the interpersonal variability in CMD susceptibility, progression and treatment response is beginning to be deciphered, as is the mutualistic relation established between the GM and diet. In particular, dietary factors emerge as pivotal determinants shaping the architecture and function of resident microorganisms in the human gut. In turn, intestinal microbes influence the absorption, metabolism, and storage of ingested nutrients, with potentially profound effects on host physiology. Herein, we present an updated overview on major effects of dietary components on the GM, highlighting the beneficial and detrimental consequences of diet-microbiota crosstalk in the setting of CMD. We also discuss the promises and challenges of integrating microbiome data in dietary planning aimed at restraining CMD onset and progression with a more personalized nutritional approach.

Surgical management of clubfoot overcorrection: a case series.

Overcorrection is a possible complication of clubfoot treatment, whose prevalence varies from 5 to 67%. Overcorrected clubfoot usually presented as a complex flatfoot with different degrees of hindfoot valgus, flat top talus, dorsal bunion, and dorsal navicular subluxation. The management of clubfoot overcorrection is challenging, and both conservative and surgical treatments are available. This study aims to present our experience in the surgical management of overcorrected clubfoot and to provide an overview of actual treatment options for each specific sub-deformity. A retrospective cohort study of patients surgically treated for an overcorrected clubfoot from 2000 to 2015 at our Institution was conducted. Surgical procedures were tailored to the type and symptomatology of the deformity. A medializing calcaneal osteotomy or subtalar arthrodesis was performed for hindfoot valgus. Subtalar and/or midtarsal arthrodesis were considered in cases of dorsal navicular subluxation. The first metatarsus elevatus was addressed through a proximal plantarflexing osteotomy, sometimes associated with a tibialis anterior tendon transfer. Clinical scores and radiographic parameters were obtained pre-operatively and at the last follow-up. Fifteen consecutive patients were enrolled. The series included 4 females and 11 males, with a mean age at surgery of 33,1 (18-56) years, and a mean follow-up of 4,46 (2-10) years. Seven medializing calcaneal osteotomies, 5 subtalar arthrodesis, 11 first metatarsal plantarflexing osteotomies, and 7 anterior tibialis tendon transfers were performed. A statistically significant improvement in both clinical and radiographic scores was observed. Management of overcorrected clubfoot involves many surgical techniques because of the high interpersonal variability of the deformities. The surgical approach showed positive results, as long as the indication is based on clinical symptoms and functional impairment rather than morphological alterations and radiographic findings.

How I do it — asleep DBS placement for Parkinson’s disease

BackgroundTraditionally, functional neurosurgery relied in stereotactic atlases and intraoperative micro-registration in awake patients for electrode placement in Parkinson’s disease. Cumulative experience on target description, refinement of MRI, and advances in intraoperative imaging has enabled accurate preoperative planning and its implementation with the patient under general anaesthesia.MethodsStepwise description, emphasising preoperative planning, and intraoperative imaging verification, for transition to asleep-DBS surgery.ConclusionDirect targeting relies on MRI anatomic landmarks and accounts for interpersonal variability. Indeed, the asleep procedure precludes patient distress. A particular complication to avoid is pneumocephalus; it can lead to brain-shift and potential deviation of electrode trajectory.

PENGARUH KOMUNIKASI INTERPERSONAL TERHADAP KEKERASAN DALAM PACARAN SISWA SMK

The purpose of this study was to determine the significance of the influence of interpersonal communication on students dating violence in XII Tata Busana class of SMK PGRI 1 Salatiga. This type of research uses a causal comparative approach. The population of this research is students of XII Tata Busana class at SMK PGRI 1 Salatiga for the academic year 2022/2023 with a total of 40 students. The research sample was taken using total sampling technique. The data analysis technique used is simple linear regression technique with the help of the IBM SPSS Statistics 25.0 program. The results of this study indicate that there is a significant negative influence of interpersonal communication variables on students dating violence. These results are evidenced by the acquisition of a tcount value which has a negative sign of -2.408 and a significance value (p) of 0.021 <0.05 is obtained

(433) Exploratory Analysis of Women’s Perception of Flibanserin’s Impact on Their Relationship with Their Partner

Abstract Introduction Most women suffering from HSDD are married or living with a partner. A market research survey of women with self-described low sexual desire and related distress assessed women's attitudes to their low sexual desire and how they perceived their condition impacted their relationship with their partner. Most women responded that they believed their condition negatively impacted some aspect of their relationship with their partner. Flibanserin is approved to treat premenopausal women suffering from HSDD. However, there is limited data on the impact of treatment on partner relationships. This exploratory retrospective analysis was conducted to bridge this knowledge gap. Objective The primary aim of this analysis was to explore if women with HSDD treated with flibanserin perceived changes in their relationship with their partners. Methods Eligible patient and clinician free-text encounter notes (notes) served as the primary data source for this analysis. Eligibility criteria include female, ≥18 years, seen at the clinic between September 1, 2015, and August 31, 2020, a confirmed diagnosis of HSDD or low libido (R68.82 or F52.0), prescribed ≥1 flibanserin prescription through the clinic's electronic health record (EHR) and ≥1 note documenting flibanserin usage. Data were deidentified and extracted from the clinic’s EHR and downloaded into an Excel spreadsheet. The key search terms “partner”, “spouse”, “husband”, “marriage” and “relationship” were used to identify relevant notes. Flibanserin usage dates were compared to relevant note dates to ensure they coincided. Results Over the 5-years study period, 146 women were eligible for inclusion in the analysis. Key search terms were identified in notes of fifteen (10%) women, all with documented positive HSDD treatment responses. Fourteen women had ≥ 1 relevant note that included ≥ 1 perceived positive relationship change, and one woman stated that “flibanserin helped her realize she was not the problem in her relationship". Seven (50%) women with positive changes were premenopausal, 7 (50%) were postmenopausal, and eleven (76%) were on concomitant sexual health-related medications, most notably intravaginal prasterone and testosterone. Positive relationship changes documented during treatment included: partner noticed an improvement in libido (n=5), a happier partner (n=4), more intimate with partner (n=2), better communication in the relationship (n=2), better mood with partner (n=1), partner noticed improvements in premenstrual syndrome (n=1), “now in couples therapy and much better” (n=1). Six (43%) women with positive notes reported ≥1 AE. Five women reported AEs related to CNS depression, and one woman experienced anxiety and depression. These AEs are consistent with those observed among all women treated with flibanserin at the clinic. Conclusions Relationships are complex and subject to multiple personal and interpersonal variables. Therefore, the changes reported here may not be related to flibanserin alone. However, our findings suggest that in some women who experience HSDD treatment benefits, flibanserin may also positively impact their relationship with their partner. Although informative, more extensive studies that consider couple's counseling, concomitant medications, and validated relationship satisfaction surveys are needed to verify these finding. Disclosure No

Interpersonal variables and caregiving partners' burden in cardiac illness: A longitudinal study

The literature on coping with illness has for many years viewed only the patients as the focal point of attention and support, and only recently have the needs of patients’ caregivers been acknowledged as well. In addition, studies that have focused on factors contributing to caregiving partners’ burden in the context of chronic illness have assessed mostly intrapersonal variables of either the patient or the partner, thus overlooking the dyadic and interpersonal nature of caregiving. In the current longitudinal study, we examined the contribution of interpersonal factors, such as patients’ and partners’ relationship satisfaction and social support perceptions, to caregiving partners’ burden in the context of cardiac illness. Couples comprising male patients and female caregiving partners ( N = 131) completed measures of relationship satisfaction, provided support, and received support upon patients’ admission to a cardiac rehabilitation program after an acute cardiac event (Time 1), and 3 months later (Time 2), upon program completion. Caregiving partners also completed a measure of burden at both measurement times. Path analyses revealed that partners’ relationship satisfaction, provided support, and received support, were all associated with lower levels of different dimensions of burden at both timepoints, as well as over time. Patients’ contribution to their partners’ burden was salient cross-sectionally but not over time. The findings shed light on the substantial role played by interpersonal factors in the caregiving process. Our findings suggest that both patients and partners should be regarded as caregivers and care receivers to each other.

Interpersonal theory of suicide and stressful life events in a clinical sample of adolescents in Spain.

The interpersonal theory of suicide (ITPS) provides a theoretical model for suicidal behaviour. It includes two interpersonal variables, thwarted belongingness (TB) and perceived burdensomeness (PB). This study tested the relationship between ITPS interpersonal variables and suicide risk (presence/absence of suicidal ideation and suicide attempts throughout life) in a clinical sample of Spanish adolescents. We also assessed the potential mediation effect of these variables in the well-established relationship between stressful life events (SLE) and suicide risk. We recruited 147 adolescents aged 11-17 from the Child and Adolescent Mental Health Outpatient Services of the Jiménez Díaz Foundation (Madrid, Spain). Different questionnaires were administered to assess suicidal behaviour and SLE (SITBI, The Stressful Life Events Scale) and to calculate proxy measures for ITPS interpersonal factors (SDQ, STAXI-NA, CDI). TB and PB significantly correlated with suicide risk. PB played a mediating role in the relationship between SLE and suicide risk: adolescents reporting SLE were more likely to enact suicide behaviours when they experienced higher PB. Patients scoring higher PB were more likely to receive more intense treatment but tended to abandon intervention promptly. ITPS seems useful for predicting suicide risk in an adolescent clinical sample. The results suggest an important role for PB in the SLE-suicide risk relationship and may impact the treatment process. Our exploratory findings should be addressed in future studies.