Abstract: Introduction: Multiprofessional health residents deal with high stress daily, harming patient care, which can cause emotional and interpersonal reactions that contribute to the development of Burnout Syndrome, thus disclosing the importance of identifying the at-risk conditions for the syndrome and possible protection. The objectives of this study were to describe the occurrence of burnout, its impairment dimensions and the association with sociodemographic characteristics in multiprofessional residency professionals. Method: This is a descriptive research with a quantitative approach, conducted with multiprofessional health residents from public hospitals located in a capital of the Midwest region of Brazil. The ISB - Burnout Syndrome Inventory - was employed, using six indices (Positive Organizational Conditions, Negative Organizational Conditions, Emotional Exhaustion, Emotional Distancing, Dehumanization and Professional Achievement), associated with the assessment of sociodemographic characteristics such as gender, marital status, profession, previous work, change of city, living alone, having children, getting another degree, enjoying what you do in your free time, practicing physical activity, having a religion, undergoing a therapeutic process. The logistic regression method was used to verify the association between these characteristics and the diagnosis of burnout syndrome. A total of 134 residents participated in the survey. Results: The results showed that Emotional Exhaustion is present in 91% of participants; Emotional Distance in 89.6%; Dehumanization, in 61.9%; Professional Achievement in 11.2%; Positive Organizational Conditions, in 85.1%; and Negative Organizational Conditions, n 82.1%. A positive association was observed between taking simultaneous courses, male gender and living alone. Conclusion: It is observed that the practice of therapy can reduce the chance of developing the syndrome and it is concluded that there is a high prevalence of burnout syndrome in the assessed group, with it being a response to stress defined by the presence of exhaustion, distancing and dehumanization. Despite these results, the perception of professional achievement remains independent of stress.