The Russian invasion of Ukraine on 24 February 2022 triggered widespread reactions. The global call for the isolation of Russia and its collaborator Belarus has also involved the world of sport, leading to the expulsion of Russian and Belarusian athletes from international competitions. The decisions leading to the expulsion were analyzed from the perspective of their factors, timing, and the international sports organizations’ (ISOs) traditional approach to mixing sport and politics. During these developments, various stakeholders have been exerting pressure on the ISOs by voicing their expectations towards sanctioning Russia and even using the threat of boycott. Multiple Streams Framework has been employed in an attempt to understand the decision-making processes of the Fédération Internationale de Football Association (FIFA), the Union of European Football Associations (UEFA), and the International Paralympic Committee (IPC), demonstrating that external pressure has played the overriding role in the process leading to the isolation of Russia and Belarus in international sport, marking the continuation of the recent evolution of ISOs’ approach to the interconnection between politics and sport.