Introduction. The development of science diplomacy is aimed at promotion of a state’s interests in the international arena. Russia is striving to strengthen cooperation in the field of scientific and technological development, humanitarian exchange with such MENA countries as Saudi Arabia, Egypt and the United Arab Emirates. These countries are of significant interest to Russia due to the long-standing forms of cooperation with them. The main purpose of this study is to identify science diplomacy actors, visually present them taking into consideration the process of science development in these countries and determine prospects of cooperation with Russia. Materials and Methods. In their study, the authors used data from open sources, Russian Federal State Statistics Service reports, UNESCO Science reports, World Bank database. The analysis of development of international science and technology cooperation in the three MENA countries was carried out. The authors used the descriptive method to present the main actors of science diplomacy and visually provide the science diplomacy systems. The developed models of science diplomacy of Saudi Arabia, Egypt and the United Arab Emirates enable Russia to identify the priorities in the field of science diplomacy in the context of geopolitical challenges. Results. The study identified the potential partners of Russia in Saudi Arabia, the United Arab Emirates and Egypt to strengthen international science and technology cooperation. The prospects for cooperation with these countries are fixed in the mutual agreements with Russia. The authors studied the policy of these countries in the field of international scientific and technical cooperation, considered strategic directions for the development of science diplomacy. The created models of science diplomacy reflect the main actors of science diplomacy, as well as the current interrelationship between the three MENA countries and Russia in the field of science and technology. The value of this research lies in the preparation of an extensive analytical base that helps to identify potential partners for Russia among the MENA countries, as well as identify key strategies and directions to stimulate the growth of cooperation and knowledge exchange. Discussion and Conclusion. The research has shown that in the studied Arab countries, there is an active development of scientific diplomacy. The governments of these countries are increasingly turning to science to solve political problems. The MENA region has extensive resources and scientific potential, which makes it attractive for scientific cooperation. The analysis of cooperation with these countries made it possible to identify key strategies and priorities to stimulate the growth of cooperation and knowledge exchange between the MENA countries and Russia.