International Organization For Standardization Research Articles

Mastering information security through standard implementation

This paper aims to enhance information security within an organization, considering the perennial concern for security in organizations utilizing ICT applications. Educational institutions also exhibit deficiencies in the domain of data security. The adoption of international organization for standardization (ISO) 27001-2013 served to pinpoint potential vulnerabilities and non-compliance with safety standards, aiming to minimize associated risks. Through this framework, an assessment of data security within public educational institutions in our country was conducted, focusing on a public university as a case study. Given the sensitive nature of this field, guidance is provided on identifying security-related issues based on ISO 27001 standards and on-ground situations. Surveys were employed, aligning with the required standards, to scan the prevailing situation. Data from surveys at public academic institution were collected and analyzed using the SPSS application. The findings underscore instances where security protocols can prevent or mitigate abuses, consequently enhancing the overall level of data security. Emphasizing education as a pivotal recommendation, this study advocates for educating personnel who handle sensitive data, derived from the application of these standards. This paper accounts for potential risks that could expose organizational weaknesses and thoroughly elucidates the steps and procedures undertaken in this approach, substantiated by illustrated examples.

The Advantages of Adopting the ISO/IEC 17025: 2017 Lab Management System in Calibration and Testing Laboratories

International Organization for Standardization (ISO) and International Electrotechnical Commission (IEC) standards for testing and calibration laboratories are known as ISO/IEC17025:2017, which is the standard for laboratory certification. The testing laboratory's accreditation, the methods of execution, and the tangible advantages of working with such an organization. This study examined the advantages of ISO/IEC17025:2017 implementation in Chengalpat region's calibration and testing laboratories using a descriptive research design. The advantages of putting ISO/IEC 17025:2017 into practice are the main variable in the current study. The investigator utilized a method called purposive sampling. This research is based on a survey with 180 responses. After the data was gathered, analysis was done using SPSS 20. It has been found that to implement best practices and believe in the benefits, Top Management must fully understand the advantages of enacting the ISO/IEC 17025: 2017 Lab Management System, task and lab managers must fully understand the Lab Management System ISO/IEC 17025: 2017 implementation, the management tools for the Calibration and Testing Labs, the infrastructure that is being developed for the Labs, teams must collaborate, and accountability is linked to the Labs.

Hybrid Mentorship of Medical Laboratories to Achieve ISO 15189:2012 Accreditation in Malawi: The University of Maryland Malawi Experience.

As part of a laboratory strengthening program in Malawi to achieve and maintain International Organization for Standardization (ISO) 15189 accreditation, we intended to mentor selected HIV molecular laboratories to achieve this accreditation. Due to the COVID-19 pandemic, mentorship pivoted to a hybrid model using an Internet-based approach and on-site mentorships. We describe the implementation of this strategy, successes, and challenges. We conducted weekly, 1-hour virtual mentorship sessions for the 5 initial laboratories (cohort 1) selected based on their Stepwise Laboratory Quality Improvement Process Towards Accreditation (SLIPTA) performance score of 3 or more stars. Laboratories presented updates and supporting documents electronically, and trainings were conducted virtually. In September 2020, when travel restrictions were relaxed, we initiated hybrid mentorships and audits for cohort 1 laboratories. The same hybrid approach was used to mentor 4 additional laboratories in cohort 2. We performed descriptive analysis, and the Wilcoxon signed-rank test was used to compare the training pre-and post-test scores. Between March 2020 and May 2023, the team completed a total of 54 virtual mentorship sessions and 20 on-site visits across 9 laboratories. Overall, the team conducted 8 training sessions for 35 laboratory quality officers. Median score improvement (pre-test vs. post-test scores) was observed across individual trainings and across cohorts (P<.01). At the end of cohort 1, 4 of 5 (80%) laboratories were accredited. One laboratory that did not reach accreditation joined cohort 2. At the end of the mentoring period, all 5 cohort 2 laboratories were accredited. We demonstrated that using a hybrid mentorship model for accreditation was a successful strategy during the COVID-19 pandemic. For the first time in Malawi, this strategy resulted in accrediting 9 of the 10 HIV molecular laboratories in 3 years at a reduced cost. Continuous mentorship is key in the maintenance of accreditation.

International models of accreditation and certification for hospitals with a focus on nursing: a scoping review.

Quality assurance in hospitals is essential for ensuring patient safety, quality of care and efficiency. The nursing profession is a key contributor to healthcare quality, yet, a comprehensive overview and comparison of the role and scope of nursing as part of accreditation and certification schemes has been lacking. The aim was to identify if and to what extent international accreditation or certification schemes focus on nursing, and to compare their conceptual models and outcome indicators. A scoping review was conducted. A search strategy was developed together with a librarian and carried out in January 2024 in Medline, CINAHL, Web of Science Core Collection, Cochrane Reviews and Google Scholar. Additionally, authoritative websites of accreditation/certification holders were searched. Inclusion criteria were studies on international accreditation or certification schemes for hospital settings with relevance to nursing published in English or German. Screening and data analysis adhered to the Joanna Briggs Institute's methodology, with reporting following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guideline (PRISMA-ScR). The search identified 17.315 records. After removing duplicates and screening of titles/abstracts, 336 full-texts remained. A total of 124 studies were included, identifying seven international accreditation/certification schemes: European Foundation for Quality Management, Evaluation and Quality Improvement Program, International Organization for Standardization 9001, Joint Commission International®, Magnet Recognition Program®, Pathway to Excellence® Program, Qmentum®. The different schemes ranged from nursing-specific to having no specific focus on, but relevance for, nursing and varied in their topics, focus on structure, process and outcome quality and structure and content of requirements. Additionally, outcome indicators varied, with differences in the extent to which indicators were nurse-sensitive, compulsoriness of data collection, and use of external benchmarking. The seven international schemes show large conceptual variations as to their focus on nursing and differences in the degree of nurse-specific outcome indicators. Hospital and nursing managers, policymakers, patients and the public need to understand the content and outcome dimensions of the schemes when making decisions or assessing hospital quality data.

LATERAL STIFFNESS EVALUATION OF RESIDENTIAL ISO CONTAINER MODULE: FULL-SCALED EXPERIMENTAL AND NUMERICAL STUDIES

International Organisation for Standardisation (ISO) containers, designed to protect contents against extreme conditions, are often repurposed as temporary shelters during disasters, conflict, or urbanization. However, modifying these containers for housing greatly affects their structural integrity. Several studies have numerically and experimentally investigated the structural strength of container structures. However, there was limited information on the lateral stiffness of a residential ISO container subjected to lateral load. A piece of valuable information when the container is applied to a multi-story structure. This study proposed to conduct physical tests on two full-scaled residential ISO container structures to evaluate their lateral stiffness. Considering the actual condition of a residential container, both samples were fabricated with different sizes of openings. The finite element models of the samples were developed and analysed employing Abaqus for comparison with other studies and the experimental results. The application for lateral stiffness of ISO containers subjected to wind load was discussed based on the current design standard. The outcome of the study widened the scope of the structural behaviour of an ISO container towards the lateral stiffness of a residential container structure.

Dynamic Simulation Model of Miniature Tracked Forestry Tractor for Overturning and Rollover Safety Evaluation

This study proposes a method to construct a dynamic simulation model to implement the lateral overturning and backward rollover characteristics of an actual tractor. Based on theoretical analysis, factors affecting these characteristics are identified, which include tractor weight, track width, wheelbase, location of mass center, weight distribution, heights of front and rear axles, and geometric shapes. The location of the mass center of the actual tractor is measured based on the standard test procedure set by the International Organization for Standardization, and the remaining influencing factors are derived through measurements. A three-dimensional (3D) model of the tractor is constructed to reflect all these factors. Additionally, a simulation model utilizing this 3D model is developed using a commercial dynamic simulation software program. The ability of the model to simulate the overturning and rollover characteristics of the actual tractor is verified by comparing the static sidelong falling angle and minimum turning radius with those of the actual tractor. The errors between the characteristics of the actual tractor and those of the 3D model and dynamic simulations are shown to be less than 5%, thus indicating that the proposed method can effectively simulate the overturning and rollover characteristics of the actual tractor.

River suspended-sand flux computation with uncertainty estimation using water samples and high-resolution ADCP measurements

Abstract. Measuring suspended-sand fluxes in rivers remains a scientific challenge due to their high spatial and temporal variability. To capture the vertical and lateral gradients of concentration in the cross-section, measurements with point samples are performed. However, the uncertainty related to these measurements is rarely evaluated, as few studies of the major sources of error exist. Therefore, the aim of this study is to develop a method to determine the cross-sectional sand flux and estimate its uncertainty. This SDC (for sand discharge computing) method combines suspended-sand concentrations from point samples with ADCP (acoustic Doppler current profiler) high-resolution depth and velocity measurements. The MAP (for multitransect averaged profile) method allows obtaining an average of several ADCP transects on a regular grid, including the unmeasured areas. The suspended-sand concentrations are integrated vertically by fitting a theoretical exponential suspended-sand profile to the data using Bayesian modeling. The lateral integration is based on the water depth as a proxy for the local bed shear stress to evaluate the bed concentration and sediment diffusion along the river cross-section. The estimation of uncertainty combines ISO standards and semi-empirical methods with a Bayesian approach to estimate the uncertainty due to the vertical integration. The new method is applied to data collected in four rivers under various hydro-sedimentary conditions: the Colorado, Rhône, Isère, and Amazon rivers, with computed flux uncertainties ranging between 18 % and 32 %. The relative difference between the suspended-sand flux in 21 cases calculated with the proposed SDC method compared to the International Organization for Standardization (ISO) 4363 standard method ranges between −40 % and +23 %. This method that comes with a flexible, open-source code is the first to propose an applicable uncertainty estimation that could be adapted to other flux computation methods.

Quality Certification and Business Performance: The Portuguese Large Firms’ Case

Objective: Observe the existence of a relationship between quality certification, financial performance and bankruptcy prediction, as well as the supposed superiority of the quality certified Portuguese large companies. Theoretical Reference: In the continuous pursuit for quality, as well as its certification, the International Standard Organization (ISO), suggests, from a theoretical perspective, a possible relationship of the last one with the going concern, contributing to the companies’ economic and financial sustainability. Method: We selected Portuguese large companies (according to recommendation 2003/361/EC) with Economic Activity Codes (NACE) D and G, certified with ISO 9000 or 9001, totalling 91 companies, along with computed average company from each of these sectors. We used univariate and multivariate techniques (MDA), models of business failure prediction, considered in previous studies as the most effective for the Iberian economy (Peres and Antão, 2018; Peres and Antão, 2019), aiming to assess the companies’ performance, as well as the supposed superiority of those quality certified companies. Results and Discussion: In neither of the analysis, univariate and multivariate, was observed a superior performance of the certified companies compared to others, indicating that quality certification is not effectively related to the companies’ economic and financial performance optimization. Implications of the Research: Uncover the influence of quality certification on the economic-financial position of companies, allowing for deeper investigation into bankruptcy, sustainability and value creation. Originality/Value: The specificities of the sectors and business size, crises and the increasing of business closures make it vital to identify what will influence performance and sustainability, as no studies have been identified on this topic, focusing on Portuguese Large companies, certified via ISO 9000 or 9001.

Chromium and cobalt in leather: A Danish market survey.

Leather has been a significant source of chromium (Cr) allergy in Denmark since the 1990s. More recently, cobalt (Co) allergy has been identified in leather as a source of allergic contact dermatitis. To measure Cr and Co levels in Danish leather goods. A total of 87 leather samples were collected, all tanned in Europe. Handheld X-ray fluorescence (XRF) device was used to screen for the presence of Cr and Co. The 20 leather samples with the highest concentrations of Co and Co were tested using International Organization for Standardization (ISO)-standards. XRF analysis showed Cr in 78/87 (83.9%) samples and Co in 52/87 (59.7%), with average concentrations of 41 mg/kg (range: 0.0-77 mg/kg) and 0.22 mg/kg (range: 0.0-2.9 mg/kg), respectively. ISO 10195 and 17 075-1 testing identified Cr (VI) in 7 out of 20 samples (1.4; 0.3-4.2 mg/kg), while ISO 17072-1 detected Co in 6 of 20 samples, averaging 3.95 mg/kg (range: 0.22-7.9 mg/kg). Most leather samples contained Cr, which was expected, while Cr (VI) was detectable in seven out of twenty tested samples but only detected in one product above the regulatory limit of 3 mg/kg. A potentially significant concentration was found for Co.

Article: Exploring Shortcomings in International Trade Law in Light of the Expansion of Artificial Intelligence

The objective of this paper is to explore the shortcomings in international trade law (ITL) in view of the expansion of Artificial Intelligence (AI), and to propose some recommendations. AI is contributing to the development of international trade while giving rise to other concerns, such as nontariffs measures. Addressing the legal challenges posed by the integration of AI into various facets of society, including international trade, is of major importance. In this context, this paper explores a number of provisions of the General Agreement on Tariffs and Trade (GATT) 1994, those of the General Agreement on Trade in Services (GATS), and ends with those of the Agreement on Trade-Related Aspects of Intellectual Property Rights (TRIPS). Finally, the article proposes some recommendations to better take into account the concerns that AI may give rise to in the multilateral trading system. It highlights the need for close partnership between the World Trade Organization (WTO), the International Standardization Organization (ISO) and the International Electrotechnical Commission (IEC) to better maximize the benefits of AI while minimizing the risks in the context of international trade. Also, it highlights the importance of harmonizing regulations on the trade of AI products and AI-driven trading and the need for a change in legal design that goes beyond mere incremental adjustments.

Converging profile relationships for offshore wind speed and turbulence intensity

Abstract. This paper reduces uncertainty in the quantification of offshore wind speed and turbulence intensity. A range of industry standard relationships, including those from International Electrotechnical Commission (IEC) and International Organization for Standardization (ISO), are compared with an extensive set of met mast data collected offshore northwestern Europe over recent decades. Analysis initially focused on over 1000 independent storm peak events identified within the 10 min mean wind speed data. Time series and coherent vertical profiles were subjected to detailed scrutiny and analysis, considering wind speeds at various averaging periods, turbulence intensity and gust factors. Most peak events were associated with neutral atmospheric conditions, so they were well represented by the ISO Frøya profile, with a shear close to the IEC power law exponent of α= 0.11. A new pragmatic approximation of atmospheric stability in terms of relative shear is outlined, bringing together key elements of the IEC and ISO standards. New empirical relationships to quantify offshore wind ambient turbulence intensity are described. A simple generalised form of gust factor relationship is adopted, with a coefficient that varies with averaging period. Distinct recommendations are made for estimating peak 10 min mean winds from peaks in 1 or 3 h mean winds. Finally, a simplified workflow for the estimation of extreme offshore winds is used to show how IEC and ISO relationships can be effectively combined.

Interlaboratory comparison of endotoxin contamination assessment of nanomaterials.

Endotoxin contamination is a significant hurdle to the translation of nanomaterials for biomedical applications. Multiple reports now describe that more than one-third of nanomaterials fail early pre-clinical assessment due to levels of endotoxin above regulatory requirements. Additionally, most immunological studies or in vivo studies testing nanomaterials in the literature lack inclusion of this assessment, which may lead to false-positive or false-negative results if high levels of the contaminant are present. The currently approved methods for endotoxin contamination assessment rely on enzymatic activity and wavelength absorbance as their endpoint, and many nanomaterials can interfere with such assays. For this reason, we devised an interlaboratory comparison of endotoxin contamination assessment for a range of nanomaterials to challenge the current international organization for standardization and pharmacopeia standards. Herein, we show that detected endotoxin levels could vary considerably between groups, and, in some instances, nanomaterials could both pass and fail regulatory endotoxin limits for medical devices depending on the group undertaking the assessment, all while passing all quality criteria standards. This work emphasises the requirement for multiple assays to fully assess the endotoxin levels in a nanomaterial and highlights the need for additional assays to be developed in this space.

Two Accreditation Options for Biorepositories.

Biomedical research relies on available biomaterials and associated data, and the quality of this starting material can have a significant impact on the quality of the experimental results. In the 2000s, best-practice documents and guidelines for biorepositories were published, followed in the 2010s by standards documents used to support accreditation. The College of American Pathologists Biorepository Accreditation Program and the International Standards Organization's standard 20387 were launched in 2012 and 2018, respectively. To identify quantitative and qualitative differences between the two aforementioned biorepository accreditation standards for use by the larger biomedical research community; the results will empower biorepositories to select an accreditation program that best fits their goals. Individual requirements of both accreditation standards were identified and a bidirectional crosswalk was performed to identify gaps. Requirements were assigned to one of several standardized categories to enable comparison of the relative emphasis of different categories between the standards. Quantitatively, the College of American Pathologists program is comprehensive and stands alone, with 523 requirements, whereas the International Standards Organization program contains 167 requirements and is comprehensive through its incorporation and reference to numerous related standards documents. Qualitatively, both programs rely heavily on the implementation of an overarching quality management system and both programs can accommodate different types of biobanks (eg, human and animal). The standards differ in number of requirements, distribution of requirements across categories, and amount of reliance on separate standard documents. This information may aid in selection of an appropriate accreditation standard.

Proficiency test of SARS-CoV-2 Omicron variant detection in diagnostics samples by veterinary diagnostic laboratories

AbstractVeterinary diagnostic laboratories (VDLs) play a critical role in screening both human and animal samples for SARS-CoV-2. To evaluate the SARS-CoV-2 detection methods used by VDLs, a proficiency test was performed by the US Food and Drug Administration’s Veterinary Laboratory and Investigation and Response Network in collaboration with two other organizations. Thirty-two sets of 12 blind-coded samples were prepared by fortifying Molecular Transport Medium (MTM) or feline feces with SARS-CoV-2 Omicron variant or non-SARS-CoV-2 equine coronavirus RNA at various concentrations and shipped to 32 participants for blinded (unbiased) analysis. Results were analyzed according to the principles of International Organization for Standardization 16140-2:2016 using two approaches such as establishing the rate of detection (ROD) and the success rate by applying the analysis of binary outcome by logit approach. ROD provided the overall assessment of laboratories performance, whereas the novel logit approach provided an insight to more specific analysis based on the complexity of each sample. The ROD was 83% and 98% for MTM samples at 200 and 20000 genome copies per 100 µL, respectively. Fecal samples were classified as challenging exploratory, and results were not included in the assessment of performance but discussion purposes only. Fecal samples exhibited matrix interference impacting the performance. The ROD was 44% and 89% for fecal samples at 2000 and 20000 genome copies per 100 µL, respectively. The non-COVID coronavirus RNA, which was used to address the specificity, did not interfere with methods used. Establishing the success rate by evaluating the qualitative results (detected/not detected) applying a logit approach revealed that, out of thirty-two participants, twenty-eight had satisfactory results, one participant had unsatisfactory results, and three participants had questionable results for MTM samples. For fecal samples, three participants out of thirty-two did not meet the expectations at higher concentrations. Lower concentrations of fecal samples were excluded from this analysis. Again, the fecal samples were considered as challenge samples and the results were provided to assist participants in their continuous efforts to improve their performance and not to evaluate their performance.

Appraising correlation between international organisation for standardisation 50001 and green productivity: A study of workers in Baiji, Iraq

Studies have shown that the progress and success of companies are achieved through their ability to improve energy performance and preserve the environment. It would translate to environmentally friendly products. However, there is a paucity of studies regarding the International Organisation for Standardisation (ISO) 50001 and its role in enhancing environmentally friendly products in developing countries such as Iraq. This study investigates the correlation between ISO 50001 standards and green productivity among Baiji's refinery workers in Iraq. Utilising a structured questionnaire, data from 128 respondents were analysed using descriptive and inferential statistics. Results indicate a significant positive correlation between ISO 50001 and green productivity, underscoring the importance of energy management training in enhancing productivity and environmental protection. As part of the study’s implications, it suggests increasing the company’s management’s attention to training in energy management and green productivity. Its positive impact on improving productivity and protecting the environment through continuous improvement of inputs, processes, outputs, and feedback to the company cannot be overstated.

Effect of non-contact induction heating on HA coatings and bone cement, an ex vivo study

Background Prosthetic joint infection is a serious complication that can arise after total joint replacement surgery. When bacteria colonise an orthopaedic implant, they form biofilms that protect them from their environment, making them difficult to remove. Treatment is further complicated by a global rise of antimicrobial resistance. These protective mechanisms make treatment of prosthetic joint infection increasingly complex. Non-contact induction heating is an upcoming technology that uses heat to eradicate bacteria that are present on the surface of metallic implants. This study aims to provide insight into the feasibility of using non-contact induction heating on metallic implants that are in direct contact with other biomaterials, such as coatings composed of hydroxyapatite and bone cement composed of poly (methyl methacrylate) (PMMA). Methods Characterisation of hydroxyapatite coatings and adhesion strength tests were conducted according to standards set by the International Organisation for Standardisation (ISO 13779-2). The fixation strength of acrylic bone cement was tested according to an adapted method from ISO. Results It was found that non-contact induction heating did not significantly affect the adhesion strength of hydroxyapatite coatings. In contrast to hydroxyapatite coatings, acrylic bone cement softened temporarily as the temperature exceeded the glass transition temperature (83.38 ± 10.88°C). However, the induction heating temperature had no significant effect on the fixation strength after the cement was allowed to cool down. Conclusion This study shows the feasibility of using non-contact induction heating up to 80°C when bone cement or ceramic coatings are present in contact with infected metallic implants.

Land Cover Mapping in West Africa: A Collaborative Process

The availability of current land cover and land use (LCLU) information for monitoring the status of land resources has considerable value in ensuring sustainable land use planning and development. Similarly, the need to provide updated information on the extent of LCLU change in West Africa has become apparent, given the increasing demand for land resources driven by rapid population growth. Over the past decade, multiple projects have been undertaken to produce regional and national land cover maps. However, using different classification systems and legends has made updating and sharing land cover information challenging. This has resulted in the inefficient use of human and financial resources. The development of the Land Cover Meta Language (LCML) based on International Organization for Standardization (ISO) standards offers an opportunity to create a standardized classification system. This system would enable easier integration of regional and national data, efficient management of information, and better resource utilization in West Africa. This article emphasizes the process and the need for multistakeholder collaboration in developing a standardized land cover classification system for West Africa, which is currently nonexistent. It presents the survey data collected to evaluate historical, current, and future land cover mapping projects in the region and provides relevant use cases as examples for operationalizing a standardized land cover classification legend for West Africa.

The Influence of Information Security Management System Implementation on the Financial Performance of Indian Companies: Examining the Moderating Effect of National Culture

The extensive focus on information technology (IT) within organizations, along with the substantial significance of information security issues, has made information security a top priority for executives. The International Organization for Standardization 27001 (ISO-27001) policy outlines the requirements for an effective Information Security Management System (ISMS). Implementing an ISMS not only enhances the overall profitability of a firm, but it also has a significant impact in various scenarios. In this study, we examined how ISMS implementation can assist corporations financially, with a specific focus on the moderating effect of Indian national culture. We analyzed financial performance following ISMS and ISO-27001 implementation using sample data from 420 Indian small and medium-sized enterprises (SMEs). By analyzing 256 survey questionnaires from 420 SMEs, we found that national culture amplifies the strong interaction between ISMS implementation and SME performance in India. We found that ISMS implementation increased the profitability of recognized Indian firms, supporting study hypotheses. The findings provide valuable insights for SMEs seeking to enhance financial performance through ISMS implementation, emphasizing the moderating role of national culture in shaping these outcomes.

Constituents over Correlation: Indicators and Arctic Urban Decision-Making

Arctic city mayors influence municipal sustainability outcomes, navigating decisions on waste management, social service funding, and economic development. How do mayors make these decisions and to what extent do they integrate sustainability indicator data? Interviews with the mayors of Fairbanks, Alaska, Yellowknife, Canada, and Luleå, Sweden, revealed indicators are used on a case-by-case basis to track trends but lack systematic integration into decision-making. Constituent concerns drive agendas rather than indicator trends. Based on International Organization for Standardization (ISO) guidelines, 128 indicators grouped into 19 sustainability themes were compiled from 2000 to 2019 for the study cities. Partial Least Squares Structural Equation Modeling (PLS-SEM) was applied to examine the utility of ISO indicators as a guiding factor for sustainability trend tracking, identifying key themes for each city. Results show that indicator trends are too inconsistent and interconnected to be useful as an independent form of guidance for mayors. For Arctic municipalities, sustainability indicator datasets are useful in specific circumstances, but they do not provide the same kind of decision-making heuristic that mayors receive from direct constituent interaction. Findings emphasize the importance of more robust data collection and the development of management frameworks that support sustainability decision-making in Arctic cities.

Prediction on Chinese elderly's thermo-physiological and cardiovascular responses to non-uniform and transient thermal environment during getting-up process

Getting-up process after sleep would typically involve the non-uniform transition with temperature reduction, increased activity level, and change in clothing insulation, which is rarely explored in existing research. Due to the decline of physiological adaptability of the elderly, they may have sudden changes in physiology under transient environment. It is necessary to develop prediction models for the elderly to prevent or reduce health risks. The aim of this research is to predict the thermo-physiology and cardiovascular responses to non-uniform and transient thermal environments during getting-up process, a 4-node thermoregulatory-cardiovascular predicted model was established based on Gagge's thermoregulatory and heart rate model in International Organization for Standardization. Experimental data of twenty-six Chinese elderly subjects aged over 60 at a caring home in Chongqing both in winter and summer conditions was collected for validating. The results showed that the non-uniformity and dynamic states were 5.0–15.0 °C temperature differences between cover and bedroom. Core and overall skin temperatures decreased by 0.1–0.3 °C, while the heart rate increased by 5–10 %. Bare skin temperature decreased significantly by 0.2–1.0 °C. It implied that the process posed a potential risk to body cooling, local thermal discomfort, and cardiovascular health in the elderly, which was more severe in winter. The prediction result's error was below 6.0 %, which was more accurate by 6.0 %–18.0 % than that of typical models. This research can provide a reference for creating comfortable and healthy bedroom temperatures after sleeping for the elderly by intelligent air conditioning at residences and care homes.