International Isotope Society Research Articles

12th Workshop of the Central European Division e.V. of the International Isotope Society

AbstractV Snieckus [Queen's University, Canada]—The Directed Ortho Metalation—Cross Coupling Symbiosis in Aromatic Synthesis.N Geach, GP Randall, CJ Winfield [Scynexis, UK]—Isotopically Labelled 4‐Formylimidazole.A Studer [Marburg University, Germany]—New Concepts in Tin‐Free Radical Chemistry.AC Spivey, C Noban [Imperial College London, UK]. T Jones [Sheffield University, UK], GJ Ellames, A Kohler [Sanofi‐Synthélabo, UK], H Wadsworth [Amersham Biosciences, UK]—Opportunities for Isotope Labelling via Solid Phase Synthesis with Organogermanium Linkers.J Rieke‐Zapp [Aventis Pharma, Germany]—Optimization of Reaction Conditions on mg‐Scale by Use of Screening Devices.S Stone‐Elander [Karolinska Institute, Sweden]—Rerouting Radiochemistry with Microwaves.J Goehl, B Perry, D Leuck, J Windels, M Marx [EaglePicher Pharmaceutical, USA]—GMP and Radiolabelled Syntheses of Capsaicin.J Krüger, B Manmontri, G Fels [Paderborn University, Germany]—H/D‐Exchange in Aromatic Systems Using Transition Metal Catalysis.F Wüst, T Kniess, R Bergmann [Research Centre Rossendorf, Germany]—Synthesis of a 11C‐Labelled Nonsteroidal Glucocorticoid Receptor Ligand as Potential Radiotracer for Imaging Brain Glucocorticoid Receptors with Positron Emission Tomography (PET).P Mäding, F Füchtner [Research Centre Rossendorf, Germany], CS Hilger [Schering AG, Germany]. M Halks‐Miller, R Horuk [Berlix Biosciences, USA]—18F‐Labelling of a Potent Nonpeptide CCR1 Antagonist for the Diagnosis of the Alzheimer's Disease.L Matei, C Postolache, V Fugaru, E Condac, A Dinischiotu, M Costache [Bukarest University, Romania]—Use of [1,2‐3H] Testosterone in 5α‐ Reductase Enzymatic Activity Dosing in Dermal Fibroblast Cultures from Polycystic Ovarian Patients.L Matei, C Postolache, V Fugaru [Bukarest University, Romania]—Synthesis and Stability Studies of Acyclovir Labelled with Tritium.J Atzrodt, V Derdau [Aventis Pharma, Germany]—Studies on Directed Ortho‐Metalation (DoM) as Convenient Tool for the Synthesis of Labeled Compounds.

11th conference of the central european division e.V. of the international isotope society

AbstractS Pounds [PerkinElmer Life and Analytical Sciences, Inc., USA]—Preparation of carrier – free [Methyl‐3H] Methyl Nosylate and its Use as a Radiochemically Stable Methylating reagent.DJ Wilkinson, AN Mather, MJ Hickey, LP Kingston [Astra Zeneca, UK]—Tritio‐Dehalogenation: New Variants on an Old Theme.VG Sidorov, YB Zverkov, NF Myasoedov, IMG, Russia; IL Karpenko, EA Shirokova, DM Yanvarev, MV Yasko, YS Skoblov [EIMB, Russia], AB Susan, [IICH, USA]—The Syntheses of Labeled 3 ‘‐Azido‐3’‐Deoxythymidine Derivatives Displaying Anti‐HIV Activity.NF Myasoedov, IY Nagaev, VP Shevchenko [IMG, Russia], AB Susan [IICH, USA], G Rotert [Abbott, USA]—Synthesis of Radiolabeled [3H]ABT‐578 for ADME Studies.J Krueger, E Linnemann, G Fels [University of Paderborn, Germany]—(‐)‐[3H]Galanthamine – Labelling, Derivatization, and Application as Photoaffinity Probe.F Wuest [Research Centre Rossendorf, Germany]—Carbon‐11 Labeled Compounds in the Development of Pharmaceuticals.P Maeding, J Zessin, F Wüst [Research Centre Rossendorf, Germany], U Pleiss [Bayer HealthCare AG, Germany]—11C‐Labeling of a Taxane Derivative by [1‐11C] Acetylation.J Bloom [Amersham Biosciences, UK]—The Preparation of 2‐Methyl [ring‐2‐14C] benzyl chloride.V Derdau, R Oekonomopulos, G Schubert, H Heitsch [Aventis Pharma Deuschland GmbH, Germany]—Synthesis of 14C Labeled Angiotensin‐(1‐7)‐Receptor Agonist AVE 0991.H Andres, P Burtscher, Y Metz, T Moenius [Novartis Pharma AG, Switzerland]—C‐14 Labeling of the β‐Amino Carboxyl Moiety–Alternatives to the Acrylate Approach.F Kaegi, Y Metz, I Rodriguez, R Ruetsch [Novartis Pharma AG, Switzerland]—Effective Carbon‐14 Labelling under Microwave Irradiation.CGM Janssen, B Verreet, HAC Lenoir, JBA Thijssen [Johnson & Johnson, Belgium]—Stable Isotope Labeled Compounds as Internal Standards for LC‐MS/MS, Requirements and Some Synthetic Approaches.RP Stuerm [SafPro AG, Switzerland]—Models for Calculating the Radiation Dose after Incorporation of 3H and 14C.A. Krins [VKTA Nuclear Engineering and Analytics e.V., Germany]—Dosimetry of C‐14 Labeled Organic Compounds.E Rausch [Raytest GmbH, Germany], M Breyer, K Hucke, D Gaefke, K Schmeer [Bayer HealthCare AG, Germany]—A New Option of 14C‐Detection in Combination with Micro HPLC.

ERA—European Radiochemists Association: Report on the activities of the Working Party for Nuclear and Radiochemistry of the Federation of European Chemical Societies

The European Radiochemists Association started almost simultaneously with the appearance of the first issue of the Radiochemistry in Europe newsletter in August 1995. The objective of the European Radiochemists Association (ERA) is to extend and improve communication between radiochemists in Europe through a newsletter. Liaison persons within each country or group exchange details of their activities, set up a diary of relevant international events and exchange details of specialist equipment, facilities and technology. In the year 2000 the Federation of European Chemical Societies decided to form a working party on nuclear and radiochemistry. It is a formalisation of the European Radiochemists Association. Each chemical society is allowed to nominate a member to the Working Party on Nuclear and Radiochemistry. Currently we have 12 nominated members plus two invited and one observer. In addition to the ERA aims and objectives it proposes to put together a syllabus of radiochemistry for undergraduate and post-graduate students—this aspect has been a part of our support of the International Atomic Energy Agency initiative. Also the aim of the working party is to support other working parties and divisions, to press the Federation of the European Chemical Societies for financial structure. To this end an Expression of Interest has been tabled with the Framework 6 Programme for networking within radiochemistry in Europe. The WP will liaise with the International Isotope Society and the International Society on Radiopharmaceutical Chemistry and Biology to seek to communicate and to consider ways of working together.

10th Conference of the Central European Division e.V. of the International Isotope Society

AbstractUse of Microwaves in Organic Synthesis: Application in the Synthesis of Isotopically Labelled CompoundsPreparation of Tritium‐Labelled BIIL 260 with High Specific RadioactivitySynthesis of [3H]‐, [14C]‐ and [13C,2H]‐labelled Org 12962 DerivativesLabeling of BAY 58‐2667, an Activator of sGCPreparation and Use of [14C]N,N′‐Carbonylditriazole in the Labelling of Urea DerivativesEfficient Carbon‐14 Labeling of 2‐(3‐Hydroxypropyl)‐1H‐benzimidazoleSynthesis of Some 14C‐Labelled FungicidesC‐14 Labelling of NVP‐ABE651 and NVP‐ABE697Synthesis of Carbon‐13,14 Isotopomers of a Novel 4‐Substituted‐2‐Carboxy Tetrahydroquinoline[14C]CH2N2: A Suitable Precursor for the Preparation of 14C‐Labelled AnthracyclinesPreparative HPLC: a Useful Approach to Speed‐up the Purification of Labelled Compounds.Use of Stable Isotopes for the Biosynthesis and Biodegradation of FosfomycinMetalloradiopharmaceuticals for Nuclear MedicineStrategic outlook: Future Methods in DMPK and subsequent requirements for isotopically labelled compoundsIsotopic Imaging of Glass‐based cDNA Microarray HybridizationNew Developments in Radiation Measuring Technique

Abstract from the 9th Conference of the Central European Division e.V. of the International Isotope Society Bad Soden, Germany, June 2001. Synthesis of Labeled intermediates—a Tough Job? Dr. R. Koermeling

Journal of Labelled Compounds and RadiopharmaceuticalsVolume 45, Issue 3 p. 269-270 Conference Abstract Abstract from the 9th Conference of the Central European Division e.V. of the International Isotope Society Bad Soden, Germany, June 2001. Synthesis of Labeled intermediates—a Tough Job? Dr. R. Koermeling AG Bayer, AG Bayer rainer.koermeling.rkl@bayer-ag.de Agrochemicals Division, Research Services Isotope Chemistry, Wuppertal, GermanySearch for more papers by this author AG Bayer, AG Bayer rainer.koermeling.rkl@bayer-ag.de Agrochemicals Division, Research Services Isotope Chemistry, Wuppertal, GermanySearch for more papers by this author First published: 26 February 2002 https://doi.org/10.1002/jlcr.566Citations: 2AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat No abstract is available for this article.Citing Literature Volume45, Issue315 March 2002Pages 269-270 RelatedInformation

9th Conference of the Central European Division e.V. of the International Isotope Society

Abstract Title Author(s) Tetramethylammonium Tri‐acetoxyborotritide, a Reagent for Hydroxy‐directed Ketone Reduction H. Andres Synthesis of Tritium‐labeled Nucleosides with Anti‐HIV and Anticancer Activity G.V. Sidorov, Yu.B. Zverkov, N.F. Myasoedov, A.R. Cimpoia, A.B. Susan Tritide Reduction of Nucleosides and Carbohydrates M. Saljoughian, H. Morimoto, P.G. Williams, C. Than A New Homogeneous Complex for H/D/T Exchange Labelling R. Salter, T. Moenius. P. Ackermann. M. Studer, A. Morgan, M. Chappelle Synthesis of [26‐2H3]Brassinosteroids O.V. Konstantinova, V.A. Khripach, V.N. Zhabinskii, A.P. Antonchick, B. Schneider The Specific Activity Determination and Confirmation of Identity of a Radiolabelled Peptide Using Tandem Mass Spectrometry A.T. Rees, A. Colebrook Different Carbon‐14 Labelling Syntheses of Vardenafil D. Seidel Carbon‐14 Labelling of β‐Amino Acids and β‐Peptides M.I. Rodriguez, Y. Metz, R. Voges A Rapid Synthesis of 2‐Chioro[2,6‐144C]isonicotinic Acid T.P. Kelly, T.R. Rodgers, C. Wright Reduction of 2,4,6‐Trinitro[ring‐14C]toluene (TNT) with Baker's Yeast (Saccharomyces Cervisiae) M. Kröger, G. Fels Application of Microbiotic Methods for the Synthesis of Radiolabelled Isotopomers ‐ A Review [1] M. Mahnke, T. Moenius Screening of Storage‐Stability of 14C Radiochemicals A. Fredenhagen Application of AMS for Human ADME F. Waldmeier, R.C. Garner Binding Studies for Affinity Screening to the Exsorptive Transporter P‐Glycoprotein: [3H]Talinolol as Radioligand P. Langguth, A. Koggel, C. Dressler, G. Peinhardt, H. Spahn‐Langguth Stable Isotopes in Medicine G.E. von Unruh GMP‐Trends for Clinical Trial Samples R. Schnettler, C.R. Oechslein Changes in Radiation Protection in Law in Germany H.‐J. Reinecke Information Systems for Radiation Protection J. Gay, H. Graffunder

International Isotope Society. Abstracts of the Xth I.I.S. (UK Group) Symposium. Current themes in Isotopic chemistry.

AbstractThe tenth annual symposium of the International Isotope Society's United Kingdom Group took place at the Alderley Park site of AstraZeneca plc. The symposium was attended by over 80 delegates from academia, the pharmaceutical and agrochemical industries, life science and fine chemical companies. Delegates were welcomed to the site by Dr Peter Warner of the Medicinal Chemistry Department.The scientific programme consisted of presentations on isotopic chemistry and applications of labelled compounds, or of chemistry with significant implications for isotopic synthesis. Both short‐lived and long‐lived isotopes were represented, as were stable isotopes. The programme was split into a morning and afternoon session chaired by Dr John Harding (AstraZeneca, who also organised the excellent domestic programme) and Dr Karl Cable (Glaxo Wellcome). The meeting ended with concluding remarks from Dr Ken Lawrie (SmithKline Beecham), chairman of the UK Group. This years symposium had a larger attendance from other European countries, an excellent level of sponsorship was achieved, and the symposium proved self‐financing.The next UK group symposium is planned for early October 2001.Meeting Programme Paul Pringle [University of Bristol, UK] To what extent can Homogeneous Catalysts be Designed? Henrick Olsen [Novo Nordisk, Denmark] Mapping of Pharmaceutical Degradation Products in the Solid Dosage Form using Radiotracers. Marie‐Claire Lasne [University of Caen, France] Synthesis of New Ligands of Cholinergic Receptors. Strategies for their Radiolabelling with Positron Emitters, Carbon‐11 or Fluorine‐18. Christopher Rayner [University of Leeds, UK] Catalysis in Supercritical Carbon Dioxide ‐ What advantages does it have to Offer? Gunnar Antoni, [University of Uppsala, Sweden] Position Specific Labelling of Biomedically Interesting Compounds using Short‐Lived Radionuclides. Hugh Wiltshire [Hoffmann‐La Roche, UK] The Use of Stable‐Labelled Isotopes in Bioequivalence Studies with the HIV‐Protease inhibitor Saquinavir. Alison Hill [Kings College, UK] Elucidation of Soraphen A Biosynthesis using 2H, 13C and 18O‐Labelled Precursors. Nick Shipley [Glaxo Wellcome, UK] Preparation of P450 Substrates for use in Drug‐drug Interactions Andrew Mather [AstraZeneca, UK] Aspects of Isotopic Labelling by Parallel Chemistry. Helen Booth [Astra Zeneca, UK] Synthesis of 14C‐labelled forms of a series of Human Leukocyte Elastase Inhibitors.

International Isotope Society. Abstracts of the Xth I.I.S. (UK Group) Symposium. Current themes in Isotopic chemistry.

International Isotope Society. Abstracts of the Xth I.I.S. (UK Group) Symposium. Current themes in Isotopic chemistry.

8th Conference of the Central European Division e.V. of the International Isotope Society. Bad Soden, Germany, 10-11 June 1999. Some selected abstracts relevant for radiosynthesis

Journal of Labelled Compounds and RadiopharmaceuticalsVolume 42, Issue 10 p. 987-1022 Research Article 8th Conference of the Central European Division e.V. of the International Isotope Society. Bad Soden, Germany, 10–11 June 1999. Some selected abstracts relevant for radiosynthesis Rolf Voges, Corresponding Author Rolf Voges Drug Metabolism and Pharmacokinetics, Isotope Section, Novartis Pharma AG, CH-4002 Basel, SwitzerlandDrug Metabolism and Pharmacokinetics, Isotope Section, Novartis Pharma AG, CH-4002 Basel, Switzerland.Search for more papers by this authorUlrich Pleiss, Ulrich Pleiss Drug Metabolism and Isotope Chemistry, Bayer AG, D-42096 Wuppertal, GermanySearch for more papers by this author Rolf Voges, Corresponding Author Rolf Voges Drug Metabolism and Pharmacokinetics, Isotope Section, Novartis Pharma AG, CH-4002 Basel, SwitzerlandDrug Metabolism and Pharmacokinetics, Isotope Section, Novartis Pharma AG, CH-4002 Basel, Switzerland.Search for more papers by this authorUlrich Pleiss, Ulrich Pleiss Drug Metabolism and Isotope Chemistry, Bayer AG, D-42096 Wuppertal, GermanySearch for more papers by this author First published: 10 November 1999 https://doi.org/10.1002/(SICI)1099-1344(199910)42:10<987::AID-JLCR306>3.0.CO;2-BCitations: 2AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume42, Issue10October 1999Pages 987-1022 RelatedInformation