In a turbulent economic macro-environment, to ensure sustainable development of the state and its regions, classical commodity exchange operations are being reformatted both through changing basic partners, changing the geography of markets and product lines, and through intensifying the launch of new multinational production projects that make it possible to compensate for the loss of part of foreign supplies in the format of import substitution , generate innovative solutions based on synergy that become domestic intellectual property. The Republic of Tatarstan is one of the supporting regions of the Russian Federation, a leader in many macroeconomic indicators, investment attractiveness and quality of life. Its developments in the field of international relations and trade are analyzed from the standpoint of efficiency, features of the work of infrastructure elements, such as special economic zones, foreign representative offices, business missions, the Chamber of Commerce and Industry, the Investment Development Agency, and the Export Support Center. Conclusions are drawn about the intensification of all types of cooperation with the People's Republic of China, countries of the Muslim world and with various countries of the EAEU and the CIS, indicating the determining role of the economic structure of all partners, including the presence of preferential regimes of interaction. If increasing global trade turnover is clearly a positive process, then the selection of international industrial cooperation projects should be accompanied by in-depth business analysis of the complementarity of the goals and capabilities of the countries participating in industrial cooperation. Another important conclusion is the need to analyze the potential of Russian regions to identify opportunities for scaling the experience of Tatarstan - the presence of a foundation of industrial cooperation that is mutually beneficial for all parties and infrastructure that ensures the effectiveness of international cooperation. Differences between the Russian and regional economy as its meso-level may lead to an unsuccessful attempt to scale the best practices of the Republic of Tatarstan. In this regard, it is proposed to create a system for connecting part of the regions of the Russian Federation to the channels of international cooperation created in the Republic of Tatarstan to enhance interaction primarily with partners from the countries of the Islamic world.