You have accessJournal of UrologySexual Function/Dysfunction: Evaluation II1 Apr 2017MP84-12 DOES CALCULATED FREE TESTOSTERONE OVERCOME TOTAL TESTOSTERONE IN PROTECTING FROM SEXUAL SYMPTOMS IMPAIRMENT? FINDINGS OF A CROSS-SECTIONAL STUDY Luca Boeri, Paolo Capogrosso, Eugenio Ventimiglia, Walter Cazzaniga, Filippo Pederzoli, Davide Oreggia, Nicola Frego, Donatella Moretti, Franco Gaboardi, Emanuele Montanari, Vincenzo Mirone, Francesco Montorsi, and Andrea Salonia Luca BoeriLuca Boeri More articles by this author , Paolo CapogrossoPaolo Capogrosso More articles by this author , Eugenio VentimigliaEugenio Ventimiglia More articles by this author , Walter CazzanigaWalter Cazzaniga More articles by this author , Filippo PederzoliFilippo Pederzoli More articles by this author , Davide OreggiaDavide Oreggia More articles by this author , Nicola FregoNicola Frego More articles by this author , Donatella MorettiDonatella Moretti More articles by this author , Franco GaboardiFranco Gaboardi More articles by this author , Emanuele MontanariEmanuele Montanari More articles by this author , Vincenzo MironeVincenzo Mirone More articles by this author , Francesco MontorsiFrancesco Montorsi More articles by this author , and Andrea SaloniaAndrea Salonia More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2017.02.2653AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookTwitterLinked InEmail INTRODUCTION AND OBJECTIVES Erectile dysfunction (ED) has been associated to lower serum total testosterone (TT) levels. The utility of free T over TT is debatable. Calculated empirical estimates of free testosterone (cFT) also are commonly used and accepted. We aimed to assess the relative impact of low TT and low cFT on androgen-related sexual symptoms in men with ED as a primary compliant. METHODS Data from 485 consecutive men were analysed. Comorbidities were scored with the Charlson Comorbidity Index (CCI). Patients completed the International Index of Erectile Function (IIEF) and the Beck's inventory for Depression (BDI). Descriptive statistics tested the differences between the referent group of patients with normal TT (defined as TT>3ng/ml according to the Endocrine Society) and normal cFT (>0.065 ng/ml) (Group 1) with those who had normal TT/low cFT (Group 2); low TT/normal cFT (Group 3); and, low TT/low cFT (Group 4). Logistic regression models tested the association between clinical predictors and pathologic psychometric scores. RESULTS Overall, 338 (69.6%), 44 (9.1%), 34 (7.0%) and 69 (14.3%) patients were in Group 1, 2, 3 and 4, respectively. Compared to Group 1, Group 2 patients were older (p<0.001), had higher BMI (p<0.01) and a greater proportion of CCI>=1 (p=0.006). Likewise, Group 2 presented lower IIEF-EF (p=0.07), IIEF-SD (p=0.04), IIEF-OF (p=0.007) and lower BDI scores (p=0.02) than Group 1. Similar findings were found for Group 4 vs. Group 1. Conversely, Group 3 patients were older (p<0.001) than in Group 1, but had similar psychometric scores. At multivariable analysis, low cFT, either with normal or low TT, achieved independent predictor status for pathologic IIEF domains and BDI scores, after accounting for age, CCI, and BMI. Conversely, low TT/normal cFT was not associated with pathological psychometric scores. CONCLUSIONS Low cFT, even with normal TT, was associated with a worse clinical profile and impaired sexual and depressive parameters compared to normal TT/normal cFT in a cohort of ED patients. Of clinical relevance, normal cFT, irrespective of low TT, was not associated with signs and symptoms suggestive for testosterone deficiency. © 2017FiguresReferencesRelatedDetails Volume 197Issue 4SApril 2017Page: e1144 Advertisement Copyright & Permissions© 2017MetricsAuthor Information Luca Boeri More articles by this author Paolo Capogrosso More articles by this author Eugenio Ventimiglia More articles by this author Walter Cazzaniga More articles by this author Filippo Pederzoli More articles by this author Davide Oreggia More articles by this author Nicola Frego More articles by this author Donatella Moretti More articles by this author Franco Gaboardi More articles by this author Emanuele Montanari More articles by this author Vincenzo Mirone More articles by this author Francesco Montorsi More articles by this author Andrea Salonia More articles by this author Expand All Advertisement Advertisement PDF downloadLoading ...