One of the current global challenges is protection of the environment. Due to increased deterioration in overall global ecological safety and the environment’s sharp deterioration in certain countries and regions, the global consequences for outstanding environmental problems indicate that states must unite their efforts to prevent threats to mankind. This work is devoted to some ecological aspects of international customs law. Biodiversity loss, environmental pollution, resource degradation, and climate change are among the most serious environmental challenges. The primary objective of this paper was to analyze specific examples of international customs law instruments that include relevant prohibitions and restrictions to address such challenges.