International Cancer Conference Research Articles

Modeling Human Cancer: Report on the Eighth Beatson International Cancer Conference

One of the major challenges facing cancer researchers is the necessity to adequately model the human disease. This need is driven by goals, including validating/determining the contribution of a gene to cancer, establishing systems for drug discovery and validation, and discovering additional factors that modify the oncogenic process. Recent advances in cancer modeling were discussed at the Eighth Beatson International Cancer Conference on June 19 to 22, 2005 in Glasgow, United Kingdom. The conference was attended by 250 scientists with >130 oral and poster presentations. The research presented made use of systems ranging from two-dimensional and three-dimensional cell culture to nonmammalian and mammalian in vivo models. In addition to basic research on the fundamental processes involved in cancer, novel developments in cancer treatment were presented.

Beatson International Cancer conference: genomic regulation and cancer.

British Journal of Cancer (2002) 86, 665–668. DOI: 10.1038/sj/bjc/6600146 www.bjcancer.com© 2002 Cancer Research UK

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

The Halstedian concept of total ablation, which held sway for nearly a century, has given way to the Fisherian where the role of surgery is local disease control in a systemic disease. Fisher hypothesises that metastasis occurs early and all patients can be regarded as having metastatic disease at diagnosis, which should then be managed by systemic therapies. Certainly it can be argued that the approach of systemic therapy has been successful as patient survival has definitely improved in the last 20 years. However it is clear that surgery alone can “cure” some patients as long term survivors were seen in the pre-chemotherapy era after treatment by surgery alone. Whereas the surgical emphasis in the past was on maximal removal of tissue, the current philosophy is minimal normal tissue removal with reliance on adujuvant treatment to destroy residual low volume cancer. But can this process go too far? The Milan group showed clearly in an elegant series of controlled trials that getting closer to the tumour carried the penalty of higher local recurrence (in reality continuing growth of cancer left behind), of up to 20% especially if radiotherapy is omitted. These studies and many others in both invasive cancer and DCIS show that careful conservative surgery can produce low levels of local recurrence with reasonable cosmesis. More recently it has emerged that inadequate surgery with consequent high local recurrence rates may have a small but significant effect on survival as demonstrated in the Oxford overview of 2000. If these effects are true for in-breast recurrences they may be even greater for local recurrence in the axilla where there is ready access to systemic dissemination via the lymphatic channels. These concepts suggest that surgeons should be very careful to make sure that the trend for minimal surgery in the axilla in the form of sentinel node biopsy should be carried out to a high standard with due attention to training and learning curves.

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

International Journal of CancerVolume 100, Issue S13 p. 141-176 AbstractsFree Access Eighteenth UICC International Cancer Conference June 30–July 5, 2002 First published: 18 June 2002 https://doi.org/10.1002/ijc.9996AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume100, IssueS132002Pages 141-176 RelatedInformation

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

International Journal of CancerVolume 100, Issue S13 p. 177-207 AbstractsFree Access Eighteenth UICC International Cancer Conference June 30–July 5, 2002 First published: 18 June 2002 https://doi.org/10.1002/ijc.9995AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume100, IssueS132002Pages 177-207 RelatedInformation

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

International Journal of CancerVolume 100, Issue S13 p. 284-311 AbstractsFree Access Eighteenth UICC International Cancer Conference June 30–July 5, 2002 First published: 18 June 2002 https://doi.org/10.1002/ijc.9992AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume100, IssueS132002Pages 284-311 RelatedInformation

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

International Journal of CancerVolume 100, Issue S13 p. 431-463 AbstractsFree Access Eighteenth UICC International Cancer Conference June 30–July 5, 2002 First published: 18 June 2002 https://doi.org/10.1002/ijc.9987AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume100, IssueS132002Pages 431-463 RelatedInformation

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

International Journal of CancerVolume 100, Issue S13 p. 208-244 AbstractsFree Access Eighteenth UICC International Cancer Conference June 30–July 5, 2002 First published: 18 June 2002 https://doi.org/10.1002/ijc.9994Citations: 1AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Citing Literature Volume100, IssueS132002Pages 208-244 RelatedInformation

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

International Journal of CancerVolume 100, Issue S13 p. 245-283 AbstractsFree Access Eighteenth UICC International Cancer Conference June 30–July 5, 2002 First published: 18 June 2002 https://doi.org/10.1002/ijc.9993AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume100, IssueS132002Pages 245-283 RelatedInformation

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

International Journal of CancerVolume 100, Issue S13 p. 379-405 AbstractsFree Access Eighteenth UICC International Cancer Conference June 30–July 5, 2002 First published: 18 June 2002 https://doi.org/10.1002/ijc.9989AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume100, IssueS132002Pages 379-405 RelatedInformation

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

International Journal of CancerVolume 100, Issue S13 p. 312-344 AbstractsFree Access Eighteenth UICC International Cancer Conference June 30–July 5, 2002 First published: 18 June 2002 https://doi.org/10.1002/ijc.9991AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Volume100, IssueS132002Pages 312-344 RelatedInformation

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

Eighteenth UICC International Cancer Conference June 30–July 5, 2002

International Journal of CancerVolume 100, Issue S13 p. 105-140 AbstractsFree Access Eighteenth UICC International Cancer Conference June 30–July 5, 2002 First published: 18 June 2002 https://doi.org/10.1002/ijc.9997AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume100, IssueS132002Pages 105-140 RelatedInformation

Cancer therapies: basic and clinical perspectives in brain, prostate, and lung tumors: Naples, September, 24-27, 2000.

A continuous flow of theoretical and practical information among basic research, diagnosis, and therapeutic innovation is a crucial process to achieve a timely and effective progress in defeating human cancer. According to this essential concept, the main objective of the Fourth Joint International Cancer Conference "Cancer Therapies: Basic and Clinical Perspectives in Brain, Prostate and Lung Cancer" has been of gathering together basic scientists and clinicians who represent scientific opinion leaders in their field, to present and discuss the most recent scientific achievements in basic and clinical perspectives, advanced diagnostic and therapeutic strategies, and molecular and cellular therapeutic approaches in brain, prostate, and lung cancer.

New dimensions in cancer biology and therapy The Third Joint International Cancer Conference “New Dimensions in Cancer Biology and Therapy” was held at Capri, Italy, on 14–16 October 1999, under the sponsorship of: Sbarro Institute for Cancer Research and Molecular Medicine, Temple University, Roswell Park Cancer Institute, MCP Hahnemann University, University of Pennsylvania–School of Medicine, Italian Tumor Society, “S. Maugeri”

The most successful and productive approach to defeat cancer relies on highly integrated and interchanging cooperation between basic research, diagnosis, and therapeutic innovation. Nevertheless, much remains to be done to achieve a consistent and continuos flow of theoretical and practical information among scientists actively involved in these equally relevant fields. The major objective of the International Conferences, “New Dimensions in Cancer Biology and Therapy,” has been identified in gathering together basic scientists and clinicians who represent scientific leaders in their field, whose working efforts are focused on specific human malignancies. Thus, in pursuit of this well-defined goal, the third edition of the Conference has focused on human immunodeficiency virus (HIV) and cancer, cutaneous melanoma, and colorectal carcinoma, which are ideal clinical examples for innovative diagnostic and therapeutic intervention, as well as optimal models to unveil new mechanisms of tumor pathogenesis. J. Cell. Physiol. 183:284–287, 2000. © 2000 Wiley-Liss, Inc.