Around the world, deep borehole disposal is being evaluated for intermediate level-waste (ILW), high-level waste, and spent nuclear fuel. To facilitate a disposal concept options analysis for ILW in Australia, desktop and lab-based geoscientific investigations, together with generic post-closure safety assessments of deep borehole disposal of long-lived ILW, have been undertaken. This paper reports on geoscientific data obtained on crystalline rock and rock salt as model rocks for geological disposal. Petrophysical and mineralogical properties for these rocks have been investigated to provide realistic data for evaluation and input to post-closure safety assessments. For crystalline rock samples originating from depths between 700 to 1900 m, very low hydraulic conductivity (2 × 10−12 to 3 × 10−11 m/s) and very low porosity (0.02% to 1.2%) were obtained. The noble gas isotopic composition of fluid inclusions from the same depth interval confirmed the rock had been devoid of recent interaction with meteoric water, thus providing potentially suitable conditions for geological disposal. Rock salt from a 802-m (heterogeneous sample with 40% halite) and a 1100-m (sample with 98% halite) depth also had a low hydraulic conductivity (5 × 10−10 to 5 × 10−9 m/s at 802 m and 10−11 to 2 × 10−10 m/s at 1100 m) and very low porosity (~0.8% for the heterogenous sample and ~0.2% for the pure halite sample). Post-closure safety assessments based on numerical modeling provided bounding conditions around the thermal evolution of the disposal environment in crystalline rock for low heat generating ILW (50 W per 180-L vitrified waste canister), including exploring the sensitivity of temperature evolution within the borehole and rock environment to parameters such as heat load, borehole depth, geothermal gradients, and rock thermal conductivity. The coupling of heat transport with radionuclide migration to account for buoyancy-driven transport was shown to have a limited impact on radionuclide migration. For a disposal borehole in crystalline rock, the radionuclide concentrations and annual dose rates from key radionuclides (99Tc and 79Se) for a 500-m, 1000-m, or 3000-m deep borehole were negligible (i.e., many orders of magnitude smaller than the threshold dose the International Atomic Energy Agency considers insignificant for humans, 0.01 mSv/year). For disposal in rock salt, a suite of numerical model scenarios explored the effectiveness of the engineered barriers, including the glass matrix, primary package, and overpack, assuming diffusion-dominated transport. These scenarios illustrated that the performance of the disposal system was insensitive to the presence or absence of engineered barriers, as dose rates at late time (>105 years) were nearly identical for all scenarios. These results indicate that the natural barrier provided by the salt is very effective at containing radionuclides, while the engineered barriers serve mainly to delay the arrival of the peak dose. While the results are preliminary, the post-closure safety assessments, supported by measured data from crystalline rock and rock salt, give confidence that deep borehole disposal of long-lived ILW would result in dose rates considered insignificant for humans within a few meters from the borehole.