This paper presents crucial findings on how motivation, both internal and external, significantly influences decision-making processes at cognitive and neural levels. It highlights the role of reward anticipation and uncertainty in shaping decision-making behavior, particularly focusing on brain regions like the prefrontal cortex, amygdala, and dopaminergic pathways, which govern strategic and risk-related decisions. Studies involving psychiatric conditions, such as schizophrenia, and healthy individuals using fMRI reveal that increased motivation enhances decision-making strategies by activating frontal and parietal brain regions, while certain areas like the Orbitofrontal Cortex (OFC) show less involvement. Additionally, the essay explores the role of insight-driven internal motivation, showing that moments of sudden clarity (AHA! experiences) can elevate risk-taking behavior by stimulating the nucleus accumbens (NAcc), a key region involved in reward processing. The research also delves into strategic decision-making theories, emphasizing the balance between logical reasoning and instinctive, politically influenced decision-making processes within organizations. The essay concludes by underscoring the need for further research into the neural mechanisms linking motivation and decision-making, particularly the impact of neurotransmitter systems and individual differences in neural responsiveness to rewards. This deeper understanding could lead to enhanced strategies for improving decision-making outcomes across various fields, including healthcare, management, and personal decision-making, offering insights into the complex interplay between motivation, cognition, and neural activity.