You have accessJournal of UrologyProstate Cancer: Basic Research & Pathophysiology II (MP51)1 Apr 2020MP51-04 THE IMPORTANCE OF LYMPH NODE LOCATION, BURDEN AND TREATMENT OUTCOME IN M1 HSPC: ANALYSIS FROM THE STAMPEDE TRIAL ARMS A AND C Áine Haran*, Adnan Ali, Alexander Hoyle, Thomas Hambrock, Yatin Jain, Christopher Brawley, Claire Amos, Joanna Calvert, Gerhardt Attard, Hassan Douis, Mahesh Parmar, Nicholas James, Matthew Sydes, and Noel Clarke Áine Haran*Áine Haran* More articles by this author , Adnan AliAdnan Ali More articles by this author , Alexander HoyleAlexander Hoyle More articles by this author , Thomas HambrockThomas Hambrock More articles by this author , Yatin JainYatin Jain More articles by this author , Christopher BrawleyChristopher Brawley More articles by this author , Claire AmosClaire Amos More articles by this author , Joanna CalvertJoanna Calvert More articles by this author , Gerhardt AttardGerhardt Attard More articles by this author , Hassan DouisHassan Douis More articles by this author , Mahesh ParmarMahesh Parmar More articles by this author , Nicholas JamesNicholas James More articles by this author , Matthew SydesMatthew Sydes More articles by this author , and Noel ClarkeNoel Clarke More articles by this author View All Author Informationhttps://doi.org/10.1097/JU.0000000000000913.04AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Current metastatic burden definitions do not account for lymph node metastases (LNM) (location, size or number). Ongoing and planned metastasis directed therapy trials also vary in their LNM inclusion criteria. We report results of a comprehensive analysis of cross-sectional baseline staging scans, including full LNM status, with further linkage to clinical outcome from M1 patients in the STAMPEDE trial. METHODS: 1086 metastatic (M1) pts randomized to Arms A or C in 2:1 ratio between 5th October 2005 and 31st March 2013 were eligible for inclusion. Detailed LNM evaluation was performed using Royal College of Radiology lymph node diagnostic criteria for conventional cross-sectional imaging (CT/MRI). Scans were reviewed centrally by two readers (radiologist and urologist). LN number and size were annotated in regional (obturator, external iliac, internal iliac and sacral) and non-regional (common iliac, retroperitoneal, mediastinal) areas. Findings were correlated with clinical outcome after treatment. RESULTS: LNM distribution was evaluable for 629 men (median age 66, median PSA 115 ng/ml): 307 had lymphadenopathy. Of these, 178 had non-regional LNM (median node number 4, median maximum size 2.1 cm (range 1 to 8.1) and minimum size 1.2 cm (range 0.9 to 3.9). Following regional assessment, obturator LN disease was the most common (203 men), followed by internal (133) and external iliac (117) nodes. For non-regional LNM, 87 patients had both common iliac and retroperitoneal LN disease. All data is linked to clinical outcome following treatment, which will be reported. CONCLUSIONS: This analysis of number, size and location LNM defines LN burden in M1 HSPC using standard imaging. The data linked to STAMPEDE trial treatment outcome will help refine existing metastatic burden criteria and treatment decision making in advanced prostate cancer. Source of Funding: None disclosed © 2020 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetails Volume 203Issue Supplement 4April 2020Page: e765-e765 Advertisement Copyright & Permissions© 2020 by American Urological Association Education and Research, Inc.MetricsAuthor Information Áine Haran* More articles by this author Adnan Ali More articles by this author Alexander Hoyle More articles by this author Thomas Hambrock More articles by this author Yatin Jain More articles by this author Christopher Brawley More articles by this author Claire Amos More articles by this author Joanna Calvert More articles by this author Gerhardt Attard More articles by this author Hassan Douis More articles by this author Mahesh Parmar More articles by this author Nicholas James More articles by this author Matthew Sydes More articles by this author Noel Clarke More articles by this author Expand All Advertisement PDF downloadLoading ...