The traditional passive heat dissipation method has low heat dissipation efficiency, which is not suitable for the heat dissipation of the concentrated heat source inside the long-focal aerial camera, resulting in temperature level changes and temperature gradients in the optical system near the heat source, which seriously affect the imaging performance of the aerial camera. To solve this problem, an active heat dissipation method of liquid cooling cycle is proposed in this paper. To improve the solving efficiency and ensure simulation accuracy, a dynamic boundary information transfer method based on grid area weighting is proposed. The thermal simulation results show that the liquid cooling method reduces the heat source temperature by 70.12%, and the boundary temperature transfer error is 0.015%. The accuracy of thermal simulation is verified by thermal test, and the simulation error is less than 6.44%. In addition, the performance of the optical system is further analyzed, and the results show that the MTF of the optical system is increased from 0.077 to 0.194 under the proposed active liquid cooling cycle heat dissipation method.