Patient-centered care (PCC) can improve healthcare quality and efficiency. However, it is unclear what constitutes PCC and which individual (including information system (IS) related) factors influence people’s PCC expectations. This study identifies the dimensions of PCC and draws on empowerment theory to model the antecedents of PCC expectations. The test results of the model, based on surveying 171 individuals, indicate that internal health locus of control, information technology (IT) self-efficacy, medical outcome expectancy, and trust in healthcare providers affect people’s expectations of PCC. In addition, the current state of PCC does not meet people’s expectations along all dimensions. This study contributes to research and practice on PCC and healthcare IS.