Tidal mixing around the Kuril Island Chain (KIC) significantly modulates the transport of Okhotsk Sea Mode Water into the Pacific Ocean and, hence, the formation of North Pacific Intermediate Water. Although previous studies have revealed the dominant role of trapped K1 internal tides in driving mixing, the energetic M2 internal tides that have been observed by altimetry are not sufficiently clarified. In this study, we investigated the generation, radiation, and dissipation of semidiurnal M2 internal tides in the Okhotsk Sea using a high-resolution model. The results showed that KIC is the main generation site for M2 internal tides, with an integrated energy conversion of 2.07 GW. The generated M2 internal tides propagated over a long distance into the Okhotsk Sea and Northern Pacific Ocean and exhibited asymmetry on the two sides of the KIC. In addition, the generation of M2 internal tides on the Kashevarov Bank in the northwestern Okhotsk Sea made a minor contribution. Although the integrated dissipation of the M2 internal tides at KIC was lower than that of the K1 internal tides, the M2 internal tidal energy dissipation rates exceeded 10−8 W/kg near the topography. More importantly, energy dissipation in the far field was dominated by radiating M2 internal tides, which induced higher diapycnal diffusivity than K1 internal tides. These results revealed the important role of M2 internal tides in driving mixing at KIC and surrounding regions, which was previously overlooked.