Internal Diseases Research Articles

The state of infectious disease training in Germany before introduction of the new board certification in internal medicine and infectious diseases: past experience and future expectations

PurposeRecently, the German Medical Association introduced a new board certification in Internal Medicine and Infectious Diseases (ID). Accompanying, current experience with ID training and expectations for the new curriculum were assessed.MethodsAfter the development of a digital survey covering four main areas with 59 questions, it was distributed via the German Society for Infectious Diseases (DGI) and other networks following a snowball principle. Participation was carried out digitally in a web-based application.ResultsBetween December 2021 and February 2022, 300 datasets were included. 38.9% (114/293) of respondents had completed the additional training in ID. Of those, 54.0% (61/113) were concerned about recognition of previous training certification in the future after the establishment of the new sub-specialization. Overall, 78.5% (135/172) of respondents were satisfied or rather satisfied with the qualification gained through their training, but 8.7% (15/172) felt poorly prepared by their ID training. With regard to the inclusion of microbiology or antimicrobial stewardship (AMS) training into the new ID training curriculum, 84.6% (254/300) and 87.7% (263/300) of participants, respectively, desired an integration. Only 30.8% (53/172) felt sufficiently supported by their employer regarding childcare and 51.7% (89/172) reported missing support for scientific commitment.ConclusionOverall, ID training in Germany seems satisfactory so far, but there is uncertainty about future recognition. Participants find that AMS and microbiology training should be integrated into new ID training curricula. New concepts regarding the compatibility of childcare and career as well as the support of scientific commitment seem essential to attract young professionals to the field.

Zinc Status of Horses and Ponies: Relevance of Health, Horse Type, Sex, Age, and Test Material

Little is known about the animal- and diet-related factors that could interfere with the plasma zinc (Zn) concentrations of equines. Additionally, the adequacy of plasma to reflect changes in the Zn intake is unclear. In the first part of this study, the plasma Zn concentrations of hospitalized horses and ponies (n = 538) were measured and evaluated for the impact of the age, sex, horse type, and internal diseases of the animals. In the second part, the effects of increasing dietary Zn chloride hydroxide and Zn methionine supplementations were assessed on the plasma and mane hair Zn concentrations of healthy horses (n = 2) and ponies (n = 8). Part 1: The age, sex, and horse type did not influence the plasma Zn concentrations. No effect of internal diseases was observed, with the exception of higher plasma Zn concentrations in animals with metabolic disorders compared to the control group (p < 0.05). Part 2: Both Zn supplements dose-dependently increased the Zn concentrations in the mane hair (p = 0.003), but not in the plasma of the horses and ponies. In conclusion, the plasma Zn concentrations were widely unaffected by nutritional and non-nutritional factors in equines, while mane hair samples better reflected the dietary Zn supply.

2DSc, professor head of the Department of Internal Diseases and cardiology №2, Samarkand State Medical University, Samarkand, Uzbekistan

2DSc, professor head of the Department of Internal Diseases and cardiology №2, Samarkand State Medical University, Samarkand, Uzbekistan

Influence of Disease Acceptance on the Quality of Life of Patients with Ankylosing Spondylitis – Single Centre Study

Ankylosing spondylitis (AS) is a chronic, progressive disease, often with multiple complications, with periods of exacerbation and remission. The onset of the disease usually affects people under 30 years of age. The disease impairs physical, psychological, and social functioning, leading to disability. Therefore, patients with AS face the challenge of adapting to life with the condition and deteriorating quality of life (QoL). This study aimed to assess the impact of disease acceptance on quality of life in patients with AS. The study was conducted in the Department of Rheumatology and Internal Diseases of the University Hospital in Wrocław among 110 patients (67 men and 43 women) with the diagnosis of AS, aged 20-89 years (M=48.44 years, SD±12.55). The study used the Acceptance of Illness Scale (AIS), the WHOQoL-BREF Quality of Life Scale, and a self-constructed questionnaire of clinical and sociodemographic data. Respondents rated the quality of life as good and moderate (M = 3.49 points, SD=±0.84). The mean AIS score was 27.44 (SD=±8.67). AIS scores are positively correlated with all QoL domains and perception of quality of life and health (p<0.001). The strongest correlation was in the physical domain (r=0.71), while the weakest correlation was observed in the social domain (r=0.329). AIS and QoL measures showed significant relationships with selected sociodemographic data (eg, gender, age, education, and occupational activity) and correlated with selected disease data (eg, type of treatment used, duration of disease, or comorbidities). AIS in patients with AS condition correlated positively with their QoL in all domains. Both disease acceptance and quality of life are influenced by specific sociodemographic and disease-related data. Prevention of complications and the type of treatment for AS (primarily biological treatment) can be essential in improving patients' quality of life.

Choosing of method for studying food consumption depending on the purpose of the clinical research (literature review)

Dietary assessment methods provide information about the quantity and quality of foods and dishes that make up the diet of individual. As a rule, this kind of information is collected during epidemiological studies. However, taking into account the role of nutrition in the development and progression of internal diseases, the importance of dietary modification for their treatment and prevention, analysis of the diet and structure of the nutrition may be an important additional tool in the clinical practice, which is able to increase the effectiveness of therapy and improve the prognosis of patients. In addition, information about the patient’s actual nutrition can be used to assess the risk of developing chronic non-communicable diseases, to determine the scope of examination and identify the causes of symptoms, and guide management to determine the frequency of observation. Thus, dietary assessment methods, the different frequency of their use and distinct combinations, make it possible to obtain various types of information about the structure of nutrition and eating habits of an individual or group of individuals in a certain area at a certain point of time in the past or present.&#x0D; The inclusion of methods for assessing actual food intake in the protocols of clinical trials is an important measure, and this article discusses the main types of questionnaires, which are both of scientific interest and of practical importance, conditions and limitations of their use and their possible combinations to optimize the information obtained.

АНАЛИЗ ТЕМАТИКИ ДИССЕРТАЦИОННЫХ РАБОТ ПО НАПРАВЛЕНИЮ «ВНУТРЕННИЕ БОЛЕЗНИ»

The purpose of the work: to determine the development of healthcare in the republic. In this work analyzed 32 dissertations for the period from 1972 to 2021. The analysis of the topics of dissertations is carried out in the main areas of research conducted on the territory of the Republic of Sakha (Yakutia). Dissertations were analyzed using content analysis. The analysis of the topics of dissertations was carried out by in following main trends: "Conducting epidemiological studies"; "Clinical and laboratory diagnostics of the disease"; "Improving the methods of prevention and treatment"; "Improving the organization of medical care and the system of training medical personnel". Works in the direction of "Internal diseases" account for 51% of the total number of dissertations performed at Yakutsk State University (NEFU named after M.K. Ammosov). The initial doctoral dissertations appeared in the late 70s. The most frequent topic of medical dissertations is the study of the clinical and laboratory picture of the disease and the improvement of the prevention and treatment of diseases The analysis showed that in the structure of dissertation research, a greater place is occupied by works devoted to the study of the clinical and laboratory picture of a certain disease and the improvement of prevention and treatment of diseases of a therapeutic profile. The features of the clinical picture and the course of diseases in the conditions of the North (41%) were characterized researchers. The largest number of works is protected during the from 1980 to 2001 years. It should be noted the decrease in the number of works since the 2000s years. Now, more attention is paid to the organization of the diagnostic and therapeutic-preventive process. Also, dissertations are defended in more "narrow" specialties, «Cardiology», «Pulmonology». The analysis of publication activity shows the predominance of scientific articles and abstracts of National bibliographic database of scientific citation. There are so few articles in scientific journals from the list of the Higher Attestation Commission.

Apalutamide in the treatment of non-metastatic castration-resistant prostate cancer in an elderly patient with multiple comorbidities

Prostate cancer has been the most common malignant tumor in men in Poland since 2016 and is the second cause of death in this group of patients. The basic method of treatment in patients with advanced prostate cancer is androgen deprivation therapy, however, over time, the tumor evolves into a castration-resistant form, which poses a significant threat to the patient's life. This article presents a case of an elderly patient with internal diseases, who in the castration-resistant stage, was treated with a new generation androgen receptor blocker – apalutamide – in the first line of systemic treatment.

Impact of clinical pharmacist’s interventions on clinical outcomes in appropriate use of colistin: a prospective pre-post intervention study

This study aims to evaluate the clinical pharmacist’s contribution impact on the appropriate use of colistin. Our study was conducted prospectively in patients in the Internal Diseases Intensive Care Unit of Gazi University Medical Faculty Hospital for eight months. The first four months of the study were with the observation group, while the next four months were with the intervention group. The study determined how the active participation of clinical pharmacists had affected the appropriateness of colistin use. The results showed that the appropriate use of colistin was higher in the intervention group than in the observational group; furthermore, incidence of nephrotoxicity was lower. The difference between both groups was statistically significant (p < 0.001, p < 0.05), respectively. This study showed that the clinical pharmacist’s active intervention by following the patients increased the frequency and percentage of the appropriate use of colistin. This decreased the incidence of nephrotoxicity, colistin’s most important side effect.

Prediction of internal fixation failure of femoral trochanteric fracture by external wall morphology

To investigate the relationship between the shape of the lateral wall and the early failure of internal fixation in the fracture of the femoral trochanteric region(FFT). Total 295 patients with femoral trochanteric fracture underwent internal fixation from January 2015 to January 2020 were selected. The patients were divided into two groups according to whether there was early internal fixation failure after surgery, 19 patients in the failure group and 276 patients in the normal group. Gender, affected side, age, AO classification, body mass index(BMI), preoperative hemoglobin, X-ray measurement of lower lateral wall thickness, preoperative internal diseases, intraoperative blood loss, postoperative tip apex distance(TAD), postoperative neck shaft angle, operation time and other data were compared between two groups. The shape of the lateral wall was compared between two groups, and the correlation between the shape of the lateral wall and the early internal fixation failure of femoral trochanteric fracture was analyzed. All patients were followed up for more than 1 year. There was no significant difference between two groups in terms of intraoperative blood loss, operation time, postoperative TAD, and postoperative neck shaft angle(P>0.05). At the latest follow-up, the visual anaglue scale (VAS) of the failure group was higher than that of the normal group(P<0.01), and the Harris score of the failure group was lower than that of normal group(P<0.05). The receiver operator characteristic (ROC) curve between shape of lateral wall and failure of early internal fixation of femoral trochanteric fracture was drawn. The critical value of the midpoint lateral wall thickness was 16.5 mm, and the area under the ROC curve was 0.845;The critical value of average sidewall thickness was 16.5 mm, and the area under ROC curve was 0.838;The critical value of the axial area of the sidewall was 7.5 mm, and the area under the ROC curve was 0.826. The shape of the lateral femoral wall measured by CT could be used as a predictive factor for the early failure of internal fixation of femoral trochanteric fractures. For patients at risk, more reasonable surgical plans and postoperative preventive measures should be developed.

THE IMPACT OF CHOLECALCIFEROL ON THE SEX HORMONES LEVEL AND SERUM BIOCHEMICAL INDICES IN RAT MALES WITH EXPERIMENTAL GONADOPATHY

THE IMPACT OF CHOLECALCIFEROL ON THE SEX HORMONES LEVEL AND SERUM BIOCHEMICAL INDICES IN RAT MALES WITH EXPERIMENTAL GONADOPATHY

ОБРАЩЕНИЕ ГЛАВНОГО РЕДАКТОРА К ЧИТАТЕЛЯМ ВЕСЕННЕГО ВЫПУСКА "БАЙКАЛЬСКОГО МЕДИЦИНСКОГО ЖУРНАЛА"

Dear readers of the Baikal Medical Journal! The editorial board strives to ensure that publications on the pages of our journal will allow a wide range of doctors, graduate students, residents, students of medical universities, scientists in the field of medicine and biology to receive modern and reliable scientific information on a wide range of issues of pathological physiology, internal diseases, surgery and related areas of medical knowledge. The format of the journal allows publishing experimental and clinical observations, original research, new techniques, literature reviews and lectures.

The role of periodontal pathology and oral cavity condition in the occurrence of general somatic diseases

The aim of the study is a review of modern national and foreign literature on the influence of the oral cavity state and the pathology of periodontal tissues, in particular generalized periodontitis, on the occurrence and severity of the course of internal organ and body system diseases. Inflammatory-dystrophic periodontal diseases lead to an increase in the level of chronic inflammatory agents due to the systemic spread of inflammatory mediators released during local tissue destruction, as well as the systemic spread of pathogenic microorganisms, which contributes to the development of cardiovascular diseases, atherosclerosis, pathological processes in the gastrointestinal tract, complicates the course of diabetes mellitus and respiratory diseases in patients with periodontal diseases. That is why the study on pathogenetic interrelations between periodontal diseases and comorbid conditions is an urgent problem of modern dentistry. Conclusions. Given that certain extraoral pathologies arise as a result of damage by disseminated periodontopathogens, it is possible to provide new therapeutic opportunities to reduce the risk of developing comorbid conditions etiopathogenetically associated with generalized periodontitis. The data of clinical and experimental studies that are presented in this literature review definitely show the need for timely treatment of periodontal diseases, which provides not only the health of the oral cavity, but also prevents the occurrence of general somatic diseases.

COMPARATIVE CHARACTERISTICS OF AMAPOSITIVE AND AMA-NEGATIVE PRIMARY BILIARY CHOLANGITIS

Primary biliary cholangitis (PBC, formerly known as primary biliary cirrhosis) is one of the most significant diseases that is predominantly verified in women. The prevalence of PBC is 1.9-40.2 per 100,000 population. Antimitochondrial antibodies (AMA) are of major importance for the diagnosis of primary biliary cirrhosis (PBC), and it has also been suggested that they may be involved in the pathogenesis of the disease. Objective: The aim of this study was to characterize the clinical, biochemical parameters and response to UDCA (Paris I criteria) PBC patients depending on AMA status in the Republic of Kazakhstan. Material and methods. The study was conducted on the basis of the Research Institute of Cardiology and Internal Diseases from 2014 to 2019. A total of 212 patients with primary biliary cholangitis were recorded. Results. Among 212 patients, 171 (80.7%) were AMA-positive and 41(19,3%) - AMA-negative. Vast majority of patients in both groups were Asian (179; 84.4%) and female (206; 97.2%). Severe disease (F3/4) was revealed in 108 (63.2%) AMA-positive and in 18 (43.9 %) AMA-negative patients (p&gt;0.05). AMA-positive and AMA-negative PBC were associated with autoimmune hepatitis in 88 (51.5%) and 10 (24.4%) cases (p&lt;0.01), rheumatoid arthritis in 26 (15.2%) and 5 (12.2%), autoimmune thyroiditis in 35 (20.5%) and 4 (9.8%), vitamin D deficiency in 89 (52.1%) and 19 (46.3%), osteoporosis in 48(28.1%) and 7 (17.1%), gallstone disease in 43 (25.4%) and 8 (21.2%) respectively (p &gt;0.05). Response to ursodeoxycholic acid (UDCA) treatment according to Paris I criteria was noted in 24 out of 81 (29.6%) AMA-positive and in 9 out of 22 (40.9%) AMA-negative patients (p&gt;0.05). Conclusion. In patients with AMA-positive PBC compared with AMA-negative, there is a statistically significant high value of autoimmune hepatitis and autoimmune thyroiditis. Whereas, response to UDCA treatment according to Paris I criteria is higher in AMA-negative PBC.

‘It’s so simple’ Lessons from the margins: a qualitative study of patient experiences of a mobile health clinic in Hamilton, Ontario, Canada

ObjectiveOur study explored the experiences of clients of HAMSMaRT (Hamilton Social Medicine Response Team), a mobile health service, in the context of their experiences of the overall healthcare system.DesignWe conducted...

Development of a new personalized staff-scheduling method with a work-life balance perspective: case of a hospital.

Burnout rates and dissatisfaction among healthcare workers remain high due to long working hours. One possible solution to this problem is to let them choose their weekly working hours and starting times in order to achieve a work-life balance. Moreover, a scheduling process that responds to changing healthcare demands at different times of the day should increase work efficiency in hospitals. In this study, a methodology and software were developed to schedule hospital personnel, taking into account their preferences regarding working hours and starting time. The software also allows the hospital management to determine the number of staff needed at different times of the day. Three methods and five working-time scenarios characterized by different divisions of working time are proposed to solve the scheduling problem. The Seniority score Priority assignment Method appoints personnel prioritizing seniority, whereas the newly developed Balanced and Fair assignment Method and Genetic Algorithm Method aim for a more nuanced distribution. The methods proposed were applied to physicians in the internal diseases department in a specific hospital. Weekly/monthly scheduling of all employees was carried out with the software. The results of scheduling factoring in work-life balance, and the performances of algorithms are shown for the hospital where the application was trialled.

Domestic researchers who significantly contributed in the study of digestive system diseases: images in art. Vasyl Parmenovich Obraztsov

Vasyl Parmenovich Obraztsov (1849 — 1920) was an outstanding therapist, Professor of Medicine, and innovator in the field of techniques for diagnosing diseases of the cardiovascular and digestive systems. The research interests of V. P. Obraztsov were mainly focused on studying the most important issues in general and specific gastroenterology and cardiology. At the same time, he aimed to invent reliable techniques for the physical diagnosis of diseases of the abdominal organs and heart.&#x0D; Palpation of the abdominal organs, invented and introduced into clinical practice by V. P. Obraztsov, is based on four principles. During deep breathing, especially when the patient is lying down, the abdominal press occasionally relaxes. During the exhalation phase, the researcher tries to reach deep into the abdominal cavity with a palpating hand and press an organ that needs to be felt against the posterior abdominal wall. The first principle of the research technique that V. P. Obraztsov came up with is deep palpation. It is usually possible to palpate any organ in the abdomen when the fingertips of the palpating hand slide off the edge of the organ being examined. The palpable part of the gastrointestinal tract is pressed against the posterior abdominal wall with a strong downward movement of the hand that is perpendicular to the organ’s long axis. When the fingers slip from the organ, the localization of the organ, as well as its consistency, shape, width, and mobility, can be determined; at the same time, the patient may report unpleasant or painful sensations. Sliding palpation is the second principle of the research technique by V. P. Obraztsov. According to topographic anatomy, each organ in the abdominal cavity has its own normal localization. Now, X‑rays confirm this, but V. P. Obraztsov had to do experiments to develop a typical topography of certain segments of the digestive tract in the abdominal cavity of a healthy person and find typical projections of internal organs on the anterior wall of the abdomen. Further studies by his students proved the correctness of his description of the topography of the abdominal organs. Of course, both V. P. Obraztsov and his students repeatedly emphasized the possibility of individual differences or physiological variants in the localization of the digestive tract organs in patients. Topographic palpation has become the third guiding principle of the research technique developed by V. P. Obraztsov. V. P. Obraztsov suggested that a study of the organs in the abdomen be done in a certain sequence. First, the sigmoid colon is examined, then the cecum, the terminal segment of the small intestine, the appendix, the stomach, with an attempt to palpate its small and large curvatures, and the pylorus. After that, the palpation of the transverse colon and the ascending and descending sections of the large intestine starts. The examination is completed by determining the localization, consistency, shape, mobility, and other features of the parenchymal organs — the liver, spleen, and kidneys. Thus, systematic palpation is the fourth principle of the examination of the abdominal organs.&#x0D; V. P. Obraztsov made a significant contribution to the history of cardiology. Systematic cardiac auscultation with a stethoscope and directly with the ear let him describe some features of the tone I, report the presence of a normal tone III, and point out the relatively frequent detection of bifurcation and splitting of heart tones. A series of works by V. P. Obraztsov on the study of the gallop rhythm is of particular importance for cardiology.&#x0D; In 1950, on the centenary of his birth, the government of the Ukrainian SSR decided to publish his «Selected Works», build a monument, and assign his name to the Department of Internal Diseases No. 1 of the Kyiv Medical Institute. By the same date, the country’s medical journals had published his students’ memoirs, as well as articles and essays about his life path.&#x0D;

The ambulatory transoral endoscopic thyroidectomy vestibular approach is safe and economical for patients with thyroid nodules.

Ambulatory thyroid surgery has been increasingly performed in recent years. However, the feasibility of the ambulatory transoral endoscopic thyroidectomy vestibular approach (TOETVA) has not been evaluated. We aimed to evaluate the safety, economy, and mental health outcomes of ambulatory TOETVA. We retrospectively reviewed the data of patients who underwent TOETVA between March 2019 and August 2022. The procedure was performed by a skilled surgical team from the Department of Thyroid Surgery of the affiliated Yantai Yuhuangding Hospital of Qingdao University. Patients were enrolled in the ambulatory (n=166) and conventional (n=290) groups, based on their chosen procedure. We analyzed patients' clinical characteristics, surgical outcomes, Hamilton Anxiety Rating Scale (HAM-A) scores, and hospitalization costs. Of 456 patients, 166 underwent ambulatory TOETVA and 290 underwent conventional TOETVA. No significant differences were found in clinical and surgical characteristics between the groups, including sex (P=0.363), age (P=0.077), body mass index (P=0.351), presence of internal diseases (P=0.613), presence of Hashimoto's thyroiditis (P=0.429), pathology (P=0.362), maximum tumor diameter (P=0.520), scope of surgery (P=0.850), or operative time (P=0.351). There were no significant differences in maximum tumor diameter (P=0.349), extrathyroidal tissue invasion (P=0.516), number of retrieved central lymph nodes (P=0.069), or metastatic central lymph nodes (P=0.897) between the groups. No significant differences were found in complications, including transient hypoparathyroidism (P=0.438), transient vocal cord palsy (P=0.876), transient mental nerve injury (P=0.749), permanent mental nerve injury (P=0.926), and other complications (P=1.000). Ambulatory patients had shorter hospital stays (P<0.001) and reduced hospitalization costs (P<0.001). There was no significant difference in HAM-A scores between the groups (P=0.056). Ambulatory TOETVA is a safe, feasible, and cost-effective procedure for selected patients. This procedure resulted in shorter hospital stays, decreased medical costs, and did not increase patient anxiety. To ensure patient safety, surgical teams must inform patients of the indications, when to seek help, and how to receive the fastest medical attention.

Role Of Hypertension and Obesity as Risk Factors for Ihd

Background: Hypertension and obesity are two major modifiable risk factors for CAD, most of the time there will be more than two risk factors in an IHD. Obesity itself cause insulin resistance to initiate type -2 DM. is the most common and significant RFs for IHD, and proper BP management is the cornerstone of both direct and indirect prevention. Overweight and obesity account for more than 80% of CHD patients. Obesity is sometimes viewed as a "minor" CHD RF; however, it is a widely effective risk-factor approach. A range of "major" risk factors have been proven to be significantly influenced by weight loss, including HTN, hyperlipidemia and insulin resistance/T2DM. Aim: To assess arterial hypertension and obesity as risk factors of IHD. Methods: This cross-sectional study which was done retrospectively by collecting data from database of "Scientific Research Institute of Cardiology and Internal Diseases" Almaty city, Kazakhstan during 2020. IHD confirmed by history, physical exam, angiography and other lab findings. Result: The research involved a total of 649 participants. The mean age of study population was 64.2±9.24 (P = 0,000). Mean of SBP and DBP were 180.73±34.9; 99.48±14.28 mmHg respectively. Number of females with normal BMI 50(21.6%), overweight 93(40.10%), obesity class – 1, 59(25.4%), obesity class – 2, 23(9.90%) and obesity class – 3, 7(3%), (P = 0.486). Number of males with underweight BMI 1(0.20%), normal BMI 96(23%), overweight 190(45.6%), obesity class – 1, 89(21.3%), obesity class – 2, 29(7%) and obesity class – 3, 12(2.9%). (P = 0.486). The Mean BMI in both genders was (28.72±11.79). Conclusion: The burden of CVDs and their related risk factors are significant in Almaty, posing a major public health concern. For accurate management and implementation of preventive measures in this area, effective strategies in management, education, and healthcare centers are needed.

Ash, Protein And Salinity Analysis Of Integrated Formulation Of Herbs And Spices In Typical Simalungun “Tinuktuk” North Sumatera-Indonesia

Tinuknuk is a special sauce from Simalungun Regency, North Sumatra Province, tinuktuk warms the body and is believed to be able to cure various internal diseases, especially to help post-natal recovery. This study aims to determine the optimal nutritional value of the main components, namely red ginger with black pepper in the ratio composition: 70:30%, 60:40%, 50:50%, 40:60%, and 30:70% using the method oven at a temperature of 105℃. Then the ash content, protein content, and salt content were tested. The results showed that the ash content was 6.98%, respectively; 6.91%; 6.90%; 6.84%, and 6.73%. The salt content is 0.57%, respectively; 0.57%; 0.57%; 0.57%, and 0.57%. The protein content was 10.43%, respectively; 10.93%; 12.43%; 11.81%, and 10.62%.

The interaction between microbiota and immune in intestinal inflammatory diseases: Global research status and trends.

This study aimed to conduct a bibliometric analysis of the relevant literature on the interaction between microbiota and immune in intestinal inflammatory diseases, and show its current status, hotspots, and development trends. The related literature was acquired from the Web of Science Core Collection on October 12, 2022. Co-occurrence and cooperation relationship analysis of authors, institutions, countries, references, and keywords in the literature were carried out through CiteSpace 6.1.R3 software and the Online Analysis platform of Literature Metrology. At the same time, the relevant knowledge maps were drawn, and the keywords cluster analysis and emergence analysis were performed. 3,608 related publications were included, showing that the number of articles in this field is increasing year by year. The results showed that Gasbarrini A and Sokol H were the authors with the highest cumulative number of articles with 25, and the institution with the most articles was Harvard University with 142 articles. The USA was far ahead in the article output, with 1,131 articles, and had a dominant role, followed by China with 707 articles. The journal Frontiers in Immunology contributed the most to this research field with 213 articles. In the cooperation network analysis, the USA, Harvard University, and Xavier RJ were the most widely collaborated country, institution, and author, respectively, which implied a high level of influence. Keywords analysis showed that there were 770 keywords, which were mainly classified as internal related diseases, such as "inflammatory bowel disease", "irritable bowel syndrome", "colorectal cancer", and the mechanism of interaction of microbiota and immune, such as "intestinal microbiota", "commensal microbiota", "regulatory T cell", "dendritic cell", "barrier function", "activation", "anti-inflammatory properties", "intestinal epithelium", and "diversity". Emerging analysis showed that future research hotspots and trends might be the short-chain fatty acid, gut dysbiosis, gut-liver axis, and fusobacterium nucleatum. This research was the first bibliometric analysis of publications in the field of interaction between microbiota and immune in intestinal inflammatory diseases using visualization software and data information mining, and obtained the current status, hotspots, and development of this field, which provides a theoretical basis for its scientific research.