The dynamic of innovation-digital changes, transformation of the international economic space, the impact of the pandemic, the expansion of technological innovations and the pace of modernization are causing new challenges and creating economic threats in the future. The article examined the essence and conditions of preventive management. Based on the definition of characteristics and conditions of economic security in the international business environment, the authors emphasize the research on the use of adaptive-oriented approach. This allows to reveal the stability of resistance and the precautionary character of the system of economic security. Adaptability to the dynamic innovation development of the international business environment requires revention and prevention of economic threats and risks. There is also a need to take into account the potential of strategic management of the economic security system of enterprises with affordable resource-based resources. This will allow preventive management tools to prevent crisis processes and increase competitiveness. Therefore, preventive management of the economic security system is considered as a combination of measures aimed at ensuring the policy of prevention, prevention and elimination of the emergence of unfavorable phenomena, which threaten the activity of enterprises by maximizing the possibilities of management potential. From the position of adaptive economic security, preventive management is directly related to risk management, which is caused by the influence of threats to external and internal environments of functioning, especially in the conditions of conducting international business. That is why the authors describe external and internal preconditions for the emergence of threats for economic security of enterprises. The article describes the stages of development of strategic principles of preventive management. Taking into account the world experience of managing the security system of economic systems, measures of preventive management are proposed taking into account the influence of international business. The system of preventive management of economic security is structured in the following spheres: Industrial, managerial, functional and international business.