As an important component of the fine organic microreaction system, micromixers can realize efficient mixing of different fluids within a short distance. In spite of great progress in micromixer design for high mixing performance over the last decade, micromixers are limited by the narrowness of channels, making it impossible to operate at high throughputs. Here, we propose a novel jet-to-counterflow (JTC) micromixer, which is based on the offset fluctuation jet mechanism to build a jet-to-counterflow zone and an annular liquid film zone to promote the rapid and efficient mixing of fluids. Micro-PIV and dye visualization experiments are used to investigate the internal flow behaviors and mixing performance of the JTC micromixer. The results show that in the “jet-to-counterflow mixing zone”, the jet undergoes the transition of three flow regimes i.e. “no offset jet − stable offset jet − fluctuating offset jet” with the increase of Re under the effects of wall effect and fluid inertia. When Re = 100, the fluctuating offset jet enhances the internal perturbation, which promotes the mixing index of the micromixer within 3 mm up to 78 %. In addition, the fluctuating offset jet intensifies the disturbance of the fluid flow in the annular liquid film zone, which further enhances the fluid mixing. A mixing efficiency of 97 % is achieved in mixing experiments over flow rates ranging from 0.075 – 37.66 mL/min−1. Our results demonstrate that fluctuating offset jet can be used to enhance microfluidic internal perturbation and mixing, which provide new insights into the design of novel micromixers.
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