"Artistic conception" is the aesthetic core of Chinese painting and the essence and soul of Chinese painting. The "artistic conception" of Chinese painting is the high unity of art, nature, life and soul, forming a unique aesthetic system of Chinese painting. The "beauty of artistic conception" of Chinese painting is applied to the design of modern interior space to create space with the expression of mutuality of emptiness and reality, reckon blank as inked and symbolic implication, which can also make Chinese painting produce new visual impact in modern society. The application of the "beauty of artistic conception" of Chinese painting in interior design does not simply present the "Chinoiserie", nor is it limited to the direct imitation of Chinoiserie elements, but allows the implication of interior design to be deeply expanded, and also allows viewers to perceive the rich feelings and internal beauty associations contained in the design in the interior space. This paper will elaborate the connotation and performance characteristics of the "beauty of artistic conception" of Chinese painting, and analyze the measures and implementation methods of applying the "beauty of artistic conception" of Chinese painting to interior space design, as well as its unique value. The purpose of this paper is to innovate the design concept of modern interior space and provide a Chinese design idea, so that the interior design can reach the space design realm of "Unity of Heaven and humanity in One".