Sustainability-oriented urbanism proposes strategies to address environmental, social, and economic challenges in intermediate cities. Within the framework of the Sustainable Development Goals (SDGs), this issue of CienciAmérica highlights the importance of sustainability in cities. The energy transition of cities is necessary and represents an opportunity to promote sustainable investments, in line with SDG 7 (affordable and clean energy) and SDG 13 (climate action). Similarly, sustainable urban planning, in line with SDG 11 (sustainable cities and communities), promotes the circular economy through proper waste management, thereby reducing environmental impacts and promoting economic sectors and job creation. On the other hand, education for a culture of sustainability, in line with SDG 4 (Quality Education), is essential to create a society that is aware and proactive in protecting the environment. This volume also includes sustainable technology, innovation and economic competitiveness, key aspects in the implementation of SDG 9 (Industry, Innovation and Infrastructure). Finally, this edition calls on governments, businesses, organizations and citizens to work together to build a sustainable future, where sustainability and the economy are intrinsically linked to ensure the sustainable functioning of cities.