Abstract Exterior and interior blood purification (EIBP) refers to the combined therapy of interior blood purification (IBP) and exterior blood purification (EBP) for severe hepatitis. For one thing, integrated traditional Chinese and Western medicine therapy should be applied in IBP to reduce and prevent the generation and absorption of harmful substances in vivo. For another, EBP such as the artificial liver support system (ALSS) can extract blood from the body and various kinds of existing harmful substances in the blood can be cleared in vitro, using the treatment of plasma exchange, plasma perfusion, plasma adsorption, hemofiltration, hemodialysis. Therefore, IBP should be cooperated with EBP for the treatment of severe hepatitis, and EIBP can prevent the deterioration of this disease and lower the mortality of patients.