Intergroup contact is the leading strategy for reducing the stigma associated with mental illness. For the first time, the current study examines the effectiveness of a contemporary intergroup contact strategy, called electronic or E-contact, to reduce stigma against people diagnosed with schizophrenia. It also examines the mediating role of three target-relevant intergroup emotions, namely fear, anger, and pity. In total, 133 participants engaged in E-contact with a person diagnosed with schizophrenia (intergroup E-contact), E-contact with a person without a mental illness (intragroup E-contact), or no contact. Compared to the intragroup E-contact and no-contact conditions, intergroup E-contact reduced fear, anger, and stereotyping toward people with schizophrenia. Additionally, fear and anger, but not pity, were found to be significant affective mediators of the E-contact effect. The findings demonstrate the value of computer-mediated intergroup contact for stigma reduction, and emphasize the importance of intergroup emotions in this domain.