Higher-order spatial laser modes have recently been investigated as candidates for reducing test-mass thermal noise in ground-based gravitational-wave detectors such as advanced LIGO. In particular, higher-order Hermite-Gauss (HG) modes have gained attention within the community for their more robust behaviors against random test-mass surface deformations and stronger sensing and control capacities. Inthis Letter we offer experimental investigations on various aspects of HG mode interferometry. We have generated purified HG modes up to the twelfth order HG_{6,6} mode, with a power conversion efficiency of 38.8% and 27.7% for the HG_{3,3} and HG_{6,6} modes respectively. We demonstrate for the first time the misalignment and mode mismatch-induced power coupling loss measurements for HG modes up to the HG_{6,6}. We report an excellent agreement with the extended numerical power loss factors that in the "small power loss" region converge to 2n+1 or n^{2}+n+1 for a misaligned or mode mismatched HG_{n,n} mode. We also demonstrate the wavefront sensing (WFS) signal measurement for HG modes up to the HG_{6,6}. The measurement result is accurately in accordance with theoretical WFS gain β_{n,n-1}sqrt[n]+β_{n,n+1}sqrt[n+1] for an HG_{n,n} mode, with β_{n,n-1} being the beat coefficient of the adjacent HG_{n,n} and HG_{n-1,n} modes on a split photodetector.