This paper describes the Matlab based simulation of radio frequency interference monitoring and mitigation techniques using adaptive array antenna and null steering algorithm. The proposed research is described to show the design and implementation of the GPS transmitter and receiver system for real time navigation, location based services and last but not least tracking applications. Two interferences arriving at 35° and 55° with power greater than seven times of original GPS signals arriving at 45°. Least mean square (LMS) and recursive least square (RLS) algorithms. The proposed system has been evaluated by conducting experiments by using the simulation tool for AntiJammer. The proposed model is useful for developing the smart health care application. Results showed better performance of RLS over LMS to mitigate the effect of interference as well as noise with a higher signal to noise ratio. This system will be useful for enhancing the communication effectiveness of smarthealth care systems.