The political, economic and geopolitical presence of the United States in the South Caucasus dates back at least a century, when, after the First World War, they emerged as a global political, economic and geopolitical actor. Cooperation has increased dramatically since 1991, when the three countries gained independence after the collapse of the Soviet Union. From this perspective, the article focuses on identifying core US interests in Eurasia and attempting to define US strategic interests and priorities with respect to the region. In this sense, the main research question is how the US relations with the South Caucasus and in particular with Armenia will look like in the future, especially within the current stage of the Ukrainian conflict that began after February 2022. The article simulates and tests four scenarios for future US engagement with the South Caucasus. Based on these scenarios, it is argued that, despite the lack of strategic interests in the region, the Ukrainian conflict prompted the US to increase its presence in the South Caucasus. This study is based on strategic documents, including the US National Security Strategy (2017), the Interim National Security Strategic Guidance of 2021, other white papers, reports, and studies of US foreign policy priorities.