Interest Groups Research Articles

What drives trust in regulatory agencies? Probing the relevance of governmental level and performance through a cross-national elite experiment on EU regulation

Abstract Trust between constituent actors within the European Union (EU)’s multilevel regulatory regimes is decisive for regulatory success. Trust drives information flows, increases compliance, and improves cooperation within these regimes. Despite its importance, systematic knowledge regarding the drivers of trust within regulatory regimes is limited. This paper inquires whether trust in regulatory agencies is influenced by their affiliation with the national or EU governmental level, as well as by their performance. While existing literature predominantly focuses on why citizens place their trust in governments or regulatory agencies, this paper presents original insights regarding the formation of trust among elites within the regulatory regime, including politicians, ministerial officials, agency officials, interest groups, and regulated entities. We employ data obtained from a large-scale vignette experiment conducted in six countries involving 752 decision-makers from relevant organizations. The experimental results suggest that both public and private elite actors’ trust assessment of regulatory agencies does not hinge on cues associated with the governmental level, but rather depends on agency performance. Accordingly, belonging to the national or EU governmental level does not create a difference in trust assessment of regulatory agencies in itself. It, however, shows that particularly elite actors are rather sensitive in terms of the performance of a regulatory agency.

The NDR family of kinases: essential regulators of aging

Aging is defined as a progressive decline of cognitive and physiological functions over lifetime. Since the definition of the nine hallmarks of aging in 2013 by López-Otin, numerous studies have attempted to identify the main regulators and contributors in the aging process. One interesting group of proteins whose participation has been implicated in several aging hallmarks are the nuclear DBF2-related (NDR) family of serine-threonine AGC kinases. They are one of the core components of the Hippo signaling pathway and include NDR1, NDR2, LATS1 and LATS2 in mammals, along with its highly conserved metazoan orthologs; Trc in Drosophila melanogaster, SAX-1 in Caenorhabditis elegans, CBK1, DBF20 in Saccharomyces cerevisiae and orb6 in Saccharomyces pombe. These kinases have been independently linked to the regulation of widely diverse cellular processes disrupted during aging such as the cell cycle progression, transcription, intercellular communication, nutrient homeostasis, autophagy, apoptosis, and stem cell differentiation. However, a comprehensive overview of the state-of-the-art knowledge regarding the post-translational modifications of and by NDR kinases in aging has not been conducted. In this review, we summarize the current understanding of the NDR family of kinases, focusing on their relevance to various aging hallmarks, and emphasize the growing body of evidence that suggests NDR kinases are essential regulators of aging across species.

A model for nurturing a networked academic community: #ASCILITEMLSIG mobile learning special interest group

ABSTRACT This paper explores the development of a special interest group bound by common interests, experiences, and access to opportunities in mobile learning as a model of a networked academic development community. With core members spanning eleven educational institutes across three continents, the Mobile Learning Special Interest Group (MLSIG) was established to facilitate mobile learning praxis to enable authentic learning and learner agency through a networked community of academic practitioners and researchers. The paper identifies critical elements of the MLSIG networked community through an autoethnographic narrative from 14 self-nominated participants. These are woven into a proposed framework and model for nurturing networked academic development communities.

Where’s the beef?: the politics of health care reform in South Korea

Background: In February 2024, the South Korean government released a policy proposal for healthcare reform, with one of the main pillars being increased medical school admissions. This policy has sparked intense opposition from the physicians’ top association. Most importantly, interns and residents—the bedrock of the medical workforce in Korean hospitals—began to leave en masse. Consequently, a medical crisis emerged, in which many medical and surgical procedures were delayed.Current Concepts: According to studies on comparative health policy and systems, the crisis could be attributed to the unique characteristics of the Korean healthcare system, in which the administration and doctors have failed to establish a substantive dialogue through which policy options are examined and deliberated. These dynamics necessitated the establishment of an institutional space for interest group politics, causing both to suffer from a lack of action repertoires. The stalemate we witness reflects the enduring patterns of the same issue.Discussion and Conclusion: To ensure the success of the current initiative, institutional arrangements must be established in which policymakers and physicians make a credible commitment to each other. Alternatives, for instance, include reactivating and regularizing the Health and Medical Services Policy Deliberation Committee, which could pave the way for establishing a venue where key stakeholders can discuss future agendas, such as how to ensure improved accessibility to “essential” care and mitigate its subnational variation, thereby creating a long-term vision for new health system governance in South Korea.

Neonatal somatic oxygenation and perfusion assessment using near-infrared spectroscopy : Part of the series on near-infrared spectroscopy by the European Society of Paediatric Research Special Interest Group "Near-Infrared Spectroscopy".

In this narrative review, we summarize the current knowledge and applications of somatic near-infrared spectroscopy (NIRS), with a focus on intestinal, renal, limb, and multi-site applications in neonates. Assessing somatic oxygenation at various body locations in neonates may aid in the understanding of underlying pathophysiology of organ injury. Considering cerebral autoregulation may be active to protect the brain during systemic circulatory failure, peripheral somatic oxygenation may potentially provide an early indication of neonatal cardiovascular failure and ultimate hypoxemic injury to vital organs including the brain. Certain intestinal oxygenation patterns appear to be associated with the onset and course of necrotizing enterocolitis, whereas impaired renal oxygenation may indicate the onset of acute kidney injury after various types of hypoxic events. Peripheral muscle oxygenation measured at a limb may be particularly effective in the early prediction of shock in neonates. Using multi-site NIRS may complement current approaches and clinical investigations to alert for neonatal tissue hypoxemia, and potentially even guide management. However, somatic NIRS has its inherent limitations in regard to accuracy. Interpretation of organ-specific values can also be challenging. Last, currently there are limited prospective intervention studies, and clinical benefits need to be examined further, after the clarification of critical threshold-values. IMPACT: The assessment of somatic oxygenation using NIRS may contribute to the prediction of specific diseases in hemodynamically challenged neonates. Furthermore, it may give early warning signs for impending cardiovascular failure, and impaired cerebral circulation and oxygenation. We present a comprehensive overview of the literature on applications of NIRS to various somatic areas, with a focus on its potential clinical applicability, including future research directions. This paper will enable prospective standardized studies, and multicenter collaboration to obtain statistical power, likely to advance the field.

Valuable Content Marketing: Strategies for B2B Success

Conventional promoting strategies, known for their interruptive nature, are losing adequacy in the present computerized scene. Organizations are battling to catch B2B client consideration with meddling techniques like cold pitches and mass publicizing. This examination investigates a strong new methodology: Marketing digital content to businesses. B2B Content Advertising: A Solution to Traditional Marketing Problems B2B digital content marketing is positioned in this study as an inbound marketing strategy. Dissimilar to nosy strategies, inbound showcasing draws in clients by furnishing them with significant and applicable substance. This substance, circulated decisively through website pages, online entertainment, and different channels, encourages trust and lays out the brand as a dependable wellspring of data. Here are a few key focal points: Esteem Added Quality written substance makes all the difference: Making great substance that tends to the particular necessities and difficulties looked by B2B crowds is vital. This content ought to be seen as enlightening, important, drawing in, and convenient. From Offering to Making a difference: A shift in mindset: B2B content promoting requires a huge social shift inside showcasing groups. It requires progressing from a "offering" mindset to a "making a difference" one. This requires an adjustment of promoting goals, strategies, measurements, and ranges of abilities. The Distributer Outlook: Fruitful B2B content promoting requests a "distributing" approach. Brands should foster a profound comprehension of their interest group's data needs and purchasing venture.

When EU Agencies Set Up Advisory Committees: All About Autonomy?

AbstractEuropean Union (EU) agencies' relations with interest groups have received scarce research attention despite their relevance to bureaucratic autonomy and functioning. Such relations may be organised via advisory committees, which are durable organisational structures for regularised contact between an agency and those societal actors given membership by the agency. Advisory committees may be imposed by the legislator to control an agency or harnessed by the latter to build autonomy. The EU legislator leaves significant discretion to EU agencies regarding advisory committees. However, EU agencies' late emergence in already densely populated regulatory fields begs the question of whether the use of agency discretion is fully autonomous. A case in point is the Agency for the Cooperation of Energy Regulators (ACER), whose establishment and design of three European Stakeholder Committees are examined here. Advisory committees were needed by, but also imposed on, ACER, reflecting agency preferences to improve task performance as much as prior institutionalisation within the organisational field. Hence, factors beyond legal requirements can constrain agency discretion on how to organise the organisation of agency–interest group relations.

How to study political parties: from civil society to the state and back. The Peter Mair lecture 2023

ABSTRACT Cartel party theory has put the study of party-state relations high on the research agenda, deliberately shifting the focus of researchers away from an understanding of political parties on the basis of their relationship with civil society or, indeed, as part of civil society itself. As fruitful as this reorientation has been, this essay argues that the resulting emphasis on ‘parties as governors’ has produced downsides of its own. Cartel party theory reinforced a separation of the study of parties from the study of other membership organizations considered the very fabric of civil societies. While their governing role makes parties distinct from the latter, I argue that what parties do and how they function should be also assessed against other organizations such as interest groups or associations through which citizens engage in joint activities including but not restricted to political interest representation. The contention is that bringing the study of party back to civil society will generate a broader understanding of the possible roles political parties can (or cannot) play in contemporary democracy than an exclusive study of party as a separate genus.

Interest group resources, access, and influence: An empirical review

AbstractDo informational and financial resources systematically secure interest group access and influence on public policy, and is one of these two resources politically more valuable than the other? Answering these questions is vital to understanding some of the drivers of political inequality and skewed influence associated with contemporary democratic politics. Focusing on two of the most commonly mobilized types of resources—money and information—this article reviews 60 studies on the topic. First, a qualitative synthesis shows that informational resources tend to be at least partially positively related to access and influence, while financial resources are more ambiguously associated with both outcomes. Second, a series of meta‐regressions support this conclusion since they tend toward showing that informational resources are significantly stronger associated with these outcomes than financial resources. Thus, these results paint a more nuanced picture than the literature suggesting that moneyed interests subvert democratic politics.

Clinical Practice Patterns in Sickle Cell Disease Treatment: Disease-Modifying and Potentially Curative Therapies.

Therapeutic options for sickle cell disease (SCD) have increased recently as well as the development of updated national guidelines. It is not known how these options are being offered or to what degree guidelines are incorporated into clinical practice. This study aimed to describe practice patterns for pediatric hematologists regarding the use of disease-modifying and potentially curative therapies for SCD. A 9-section, cross-sectional electronic survey was disseminated during a 3-month period via SurveyMonkey, to members of the American Society of Pediatric Hematology/Oncology Hemoglobinopathy Special Interest Group (ASPHO HSIG). A total of 88 physician members of the ASPHO HSIG were surveyed. Ninety percent of respondents (72/80) start hydroxyurea routinely in patients with HbSS and HbSβ0 thalassemia, regardless of disease severity. Laboratory monitoring was recommended every 3 months for stable dosing in 63.8% (51/80). New therapies were recommended for patients on hydroxyurea who were still experiencing SCD complications: L-glutamine 68.5% (37/54) or crizanlizumab 93.1% (54/58). Voxelotor was recommended for patients on hydroxyurea with low hemoglobin in 65.1% (43/66) of cases. Matched sibling transplant was considered for any disease severity by 55.1% (38/69). Gene therapy trials are offered on-site by 29% (20/69). Our study demonstrated the enhanced utilization of hydroxyurea while revealing the unexplored potential of other disease-modifying therapies in SCD. These findings underscore the importance of continued knowledge acquisition about the long-term efficacy of new medical therapies and addressing barriers to the use of proven therapies and guide the development of future studies of optimal SCD management.

European survey of diagnosis and management of the polycystic ovary syndrome: full report on the ESE PCOS special interest group's 2023 questionnaire

European survey of diagnosis and management of the polycystic ovary syndrome: full report on the ESE PCOS special interest group's 2023 questionnaire

US Military Sexual Assault: How Media, Public Opinion and Interest Groups Affected Congressional Oversight

It has been more than 30 years since the first sexual assault in the US military scandal; thousands of sexual assault survivors as well as numerous legislative regulations have not been able to address effectively the situation. In 2022, the Military Justice Improvement and Increasing Prevention Act (MJIIPA) finally passed. The article addresses what changed to allow the passage of this legislation and if it will be enough to fix the problem. The research questions are: What changed during Congressional Oversight to achieve the passage of MJIIPA?  Media, Public Opinion and Interest Groups (IG) have played what role to achieve the changes in Congress? By making the changes to the COC what is to be expected? Will it be enough to address the issue? This article uses the case study method. The results of this examination demonstrate that neither media, public opinion nor interest groups provided the influence expected. It was elite cues and those committed to reforming the system as a continuous process, not an ad hoc procedure that pushed forward the reforms.   Received: 11 November 2023 / Accepted: 23 April 2024 / Published: 5 May 2024

Histochemical and ultrastructural localization of triterpene saponins in Medicago truncatula.

In the Medicago genus, saponins are complex mixtures of triterpene pentacyclic glycosides extensively studied for their different and economically relevant biological and pharmaceutical properties. This research is aimed at determining for the first time the tissue and cellular localization of triterpene saponins in vegetative organs of Medicago truncatula, a model plant species for legumes, by histochemistry and transmission electron microscopy. The results showed that saponins are present mainly in the palisade mesophyll layer of leaves, whereas in stems they are mostly located in the primary phloem and the subepidermal cells of cortical parenchyma. In root tissue, saponins occur in the secondary phloem region. Transmission electron microscopy revealed prominent saponin accumulation within the leaf and stem chloroplasts, while in the roots the saponins are found in the vesicular structures. Our results demonstrate the feasibility of using histochemistry and transmission electron microscopy to localize M. truncatula saponins at tissue and cellular levels and provide important information for further studies on biosynthesis and regulation of valuable bioactive saponins on agronomic relevant Medicago spp., such as alfalfa (Medicago sativa L.). RESEARCH HIGHLIGHTS: The Medicago genus represents a valuable rich source of saponins, one of the most interesting groups of secondary plant metabolites, which possess relevant biological and pharmacological properties. Plant tissue and cellular localization of saponins is of great importance to better understand their biological functions, biosynthetic pathway, and regulatory mechanisms. We elucidate the localization of saponins in Medicago truncatula with histochemical and transmission electron microscopy studies.

Personal and organisational health literacy in the non-specific symptom pathway for cancer: An ethnographic study.

People being investigated for cancer face a wealth of complex information. Non-specific symptom pathways (NSS) were implemented in the United Kingdom in 2017 to address the needs of patients experiencing symptoms such as weight loss, fatigue or general practitioner 'gut feeling', who did not have streamlined pathways for cancer investigation. This study aimed to explore the health literacy skills needed by patients being investigated for cancer in NSS pathways. This study employed ethnographic methods across four hospitals in England, including interviews, patient shadowingand clinical care observations, to examine NSS pathways for cancer diagnosis. We recruited 27 patients who were shadowed and interviewed during their care. We also interviewed 27 professionals. The analysis focused on patient communication and understanding, drawing on the concepts of personal and organisational health literacy. Our analysis derived six themes highlighting the considerable informational demands of the NSS pathway. Patients were required to understand complex blood tests and investigations in primary care and often did not understand why they were referred. The NSS pathway itself was difficult to understand with only a minority of patients appreciating that multiple organs were being investigated for cancer. The process of progressing through the pathway was also difficult to understand, particularly around who was making decisions and what would happen next. The results of investigations were complex, often including incidental findings. Patients whose persistent symptoms were not explained were often unsure of what to do following discharge. We have identified several potential missed opportunities for organisations to support patient understanding of NSS pathways which could lead to inappropriate help-seeking post-discharge. Patients' difficulties in comprehending previous investigations and findings could result in delays, overtestingor inadequately targeted investigations, hindering the effective use of their medical history. Third, patients' limited understanding of their investigations and results may impede their ability to engage in patient safety by reporting potential care errors. Patient, public, clinical and policy representatives contributed to developing the research objectives through a series of meetings and individual conversations in preparation for the study. We have held several events in which patients and the public have had an opportunity to give feedback about our results, such as local interest groups in North London and academic conferences. A clinical contributor (J.-A. M.) was involved in data analysis and writing the manuscript.

Legislating on economic-social rights amidst de-democratisation: lessons from a lapsed Indian bill on the right to health

ABSTRACT Due to their special nature, the economic-social rights (ESRs) – compared to civil-political rights (CPRs) – entail distinct legislative methodology. This is still a nascent area of knowledge globally. ESRs are increasingly pivotal in the trending populist governments. Also, there is growing practical clarity on the paradigm of indivisibility and interdependence of ESRs and CPRs. However, unlike CPRs, the ESRs continue to be seen as resource-contingent, and therefore not amenable to legislative regulation but to ‘progressive realization’ through policies. This article foremost contests that, and instead asserts that ESRs too are legalisable and even justiciable, though differently from CPRs. It illustrates this from a lapsed national health bill of the Indian government, drafted and steered by the author. The matrix comprising the right to health and an Indian legislative initiative is used: the right to health as a particularly complex ESR; and India as a representative democracy with rising influence of privatisation and a declining legislature. Secondly, this experience demonstrates that ESRs need alternative concepts, techniques and practices of legislating. The unfolding nature of ESRs and their deep political-economic entrenchment require nimble and intricate negotiations among competing stakeholders. This makes the ESR laws evolving non-linear processes more than finished end-products. Also, process heaviness makes their legislation necessarily complicated and slow. Thirdly, the case study shows, legislating on ESRs invokes a qualitatively different understanding of democracy. Since ESRs essentially involve multiple interest groups and the larger regulatory framework comprising both the legislature and the executive, they implicate innate democratic values. In the contemporary de-democratisation context, their long-drawn legislative process – even a disingenuous one, initiated only for legitimacy – could counter-intuitively bolster deliberative democracy. For all three reasons, the process itself – besides the enacted law, the product – deserves recognition as an underexamined critical success-indicator of legislative methodology, especially for ESRs.

Mining as a Sustainable Development: Social License vs. State license

Objective: The purpose of this study is to investigate mining activity as a sustainable development, based on the social license and the state license, with the aim of systematizing literature on obtaining the license to operate.   Theoretical Framework: This topic presents the main concepts and theories that support the research. Thus, the Social License to Operate and social conflicts stand out, providing a solid basis for understanding the context of the research.   Method: The methodology includes the review of previous research indexed in the Scopus and Web of Science databases. To do this, search strings were applied, using the Boolean operators AND, OR and NOT and applying pre-established search and screening criteria.   Results and Discussion: The main finding of the research is that Social License to Operate must have effective communication between the community and the business sector, so that possible changes related to the needs of the interest groups involved are considered in the future.   Implications of the research: the practical and theoretical implications of this research are that the qualities of the Social License to Operate have the possibility of varying social relations as long as environmental issues are addressed by the private sector and by policies. public.   Originality/Value: It contributes to the literature by showing that the Social License to Operate is gaining importance in scientific research, so that researchers open academic debate.

The Conditionality of Political Short‐Termism: A Review of Empirical and Experimental Studies

Political short-termism prioritizes short-term net policy benefits over long-term benefits and thus can hinder policy investments that impose short-term costs to society to address long-term policy challenges. This literature review explores when political short-termism can be driven and mitigated in a democratic system by reviewing empirical and experimental studies and identifying the various factors that can influence policy investments: elections, economic conditions, power-sharing arrangements, partisanship, the presence of compensation schemes, and media coverage among politicians; discounts of future policy benefits, policy trade-offs, political ideology, and socioeconomic and demographic factors among voters; and compliance costs, power-sharing arrangements, compensations, and long-term political signaling from governments among special interest groups. Finally, I discuss the findings and provide suggestions for future research.

Abstract PO2-10-02: 'Sharing Our Own Experience': A Qualitative Study of Black Women Diagnosed with Triple-Negative Breast Cancer

Abstract Introduction: Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer that is disproportionately prevalent among U.S. Black women. Black women diagnosed with TNBC are less likely to receive the primary treatment options for TNBC, and more likely to die from the disease compared to white patients with the same diagnosis. Given TNBC’s impact on Black women, there is an urgent need to better understand their needs for information and support and any unique barriers to care they may face. Thus, this study explored the perspectives, needs, and lived experiences of Black women diagnosed with TNBC. Methods: Our study was guided by the transformative paradigm and used a multi-method approach. Study-eligible participants self-identified as: a) Black or African American; b) 18 years or older; c) being diagnosed with TNBC within the previous 5-7 years; d) receiving TNBC treatment in the U.S.; and e) English-speaking. From August-October 2022, SHARE Cancer Support (a national nonprofit focused on cancer) and 15 partner organizations used social media and listservs to recruit potential participants from their constituencies to complete a quantitative survey (n=49). From the survey participants, a stratified, purposeful sample of 20 Black women diagnosed with TNBC completed in-depth interviews from November 2022-February 2023. Two Black women researchers conducted virtual interviews with the participants via Zoom. The research team performed thematic analysis on the professionally transcribed data using NVivo 12. A Black Feminist lens was used to analyze codes and interpret emerging themes present across the interviews. The University of South Carolina's Institutional Review Board approved this study. Results: About half of those interviewed were between 35 and 44 years old, had a bachelor's degree or higher, and their annual household income ranged from less than $25,000 to $175,000. Eight major themes emerged from the personal stories of Black women diagnosed with TNBC. From diagnosis to survivorship, Black women discussed the importance of advocacy, including self-advocacy, others advocating on their behalf, and being motivated to become an advocate for others. The participants shared the significance of their identity as Black women and desired that cancer care team members acknowledge their identity and subsequently culturally tailor their care needs. Some participants also noted instances of racism and discrimination that occurred during their TNBC diagnosis or treatment experience. Participants overwhelmingly stressed the vital nature of having “someone who looks like me” to inform them about treatment options and existing resources, as well as to provide emotional support through their shared lived experiences with TNBC. Additionally, participants recognized the importance of embracing the uncertain yet inevitable future. They also emphasized that mental health support is not uniformly provided in care settings but should be an essential component of the TNBC treatment plan. Having support was essential to all the women, but they noted that support can look different for everyone and many existing support resources need to be improved. The themes were adapted into a list of recommended action steps for support organizations, clinical care team members, and TNBC patients to help improve the quality of life for Black women diagnosed with TNBC. Conclusions: The lived experiences of Black women diagnosed with TNBC can serve as a meaningful source of data and provide solutions to addressing persistent health disparities these women face. Findings from this study can inform future research and clinical practice about how to support the holistic needs of Black women diagnosed with TNBC. Recommendations for improving the quality of life for Black women diagnosed with triple-negative breast cancer. The 8 major themes that emerged in the qualitative study were adapted into a list of actionable recommendations for key interest groups to improve the lives of Black women diagnosed with triple-negative breast cancer. Citation Format: Tisha Felder, Lucy Ingram, Megan Austin, Victoria Burke, Stephanie Poland, Megan-Claire Chase, Christine Benjamin. 'Sharing Our Own Experience': A Qualitative Study of Black Women Diagnosed with Triple-Negative Breast Cancer [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-10-02.

Coronary microvascular dysfunction and inflammation: Insights from the Coronary Microvascular Disease Registry

BackgroundCoronary microvascular dysfunction (CMD) is associated with various inflammatory conditions that worsen endothelial dysfunction. This study aimed to investigate the relationship between CMD and inflammation using common inflammatory markers derived from complete blood count (CBC) analysis. MethodsInformation was gathered from the Coronary Microvascular Disease Registry to examine the neutrophil-to-lymphocyte ratio (NLR), eosinophil-to-monocyte ratio (EMR), and monocyte-to-high-density lipoprotein ratio (MHR) in a cohort of patients with angina who showed non-obstructive coronary arteries and underwent invasive physiological assessments for CMD. ResultsOf the 171 patients studied, 126 were CMD-negative and 45 were CMD-positive, constituting two groups of interest. The average age of all patients was 61.7 ± 11.1 years, and 63.7 % were female. No significant differences were observed between the two groups in terms of baseline characteristics, cardiovascular risk factors, or potential anti-inflammatory medications. Furthermore, there were no statistically significant differences in NLR (2.54 ± 3.71 vs. 2.52 ± 2.28, p = 0.97), EMR (0.3 ± 0.21 vs. 0.34 ± 0.29, p = 0.31), or MHR (0.02 ± 0.01 vs. 0.01 ± 0.01, p = 0.54) between CMD-positive and CMD-negative patients. ConclusionOur findings did not show a noteworthy connection between CMD and inflammation, as suggested by various simple CBC-based biomarkers.

Phylogenomic insights into the diversity and evolution of Palearctic vipers

Despite decades of molecular research, phylogenetic relationships in Palearctic vipers (genus Vipera) still essentially rely on a few loci, such as mitochondrial barcoding genes. Here we examined the diversity and evolution of Vipera with ddRAD-seq data from 33 representative species and subspecies. Phylogenomic analyses of ∼ 1.1 Mb recovered nine major clades corresponding to known species/species complexes which are generally consistent with the mitochondrial phylogeny, albeit with a few deep discrepancies that highlight past hybridization events. The most spectacular case is the Italian-endemic V. walser, which is grouped with the alpine genetic diversity of V. berus in the nuclear tree despite carrying a divergent mitogenome related to the Caucasian V. kaznakovi complex. Clustering analyses of SNPs suggest potential admixture between diverged Iberian taxa (V. aspis zinnikeri and V. seoanei), and confirm that the Anatolian V. pontica corresponds to occasional hybrids between V. (ammodytes) meridionalis and V. kaznakovi. Finally, all analyzed lineages of the V. berus complex (including V. walser and V. barani) form vast areas of admixture and may be delimited as subspecies. Our study sets grounds for future taxonomic and phylogeographic surveys on Palearctic vipers, a group of prime interest for toxinological, ecological, biogeographic and conservation research.