In 1863, Charles Darwin opined in a letter to a friend that contemplating the origin of life was “mere rubbish thinking” and that “one might as well think of [the] origin of matter.” Many researchers today would agree with Darwin. And yet, whereas cosmologists know how particles, elements, and many molecules formed after the big bang, biologists still struggle to explain how inorganic molecules turned into the stuff of life. Natural lakes with relatively high concentrations of phosphorous compounds, such as Mono Lake in California, may have been commonplace in the prebiotic Earth, providing the phosphorus-rich environments for biology and life to take hold. Image credit: Shutterstock/Radoslaw Lecyk. While seeking signs of fossilized microbial life in Mars’ Jezero crater, once home to a river delta, NASA’s Perseverance rover could uncover evidence of ferrocyanide derivatives, which would favor a hypothesis about how life started—one in which hydrogen cyanide reacts with the abundant iron dissolved in the waters of a lake, forming ferrocyanide, and causing cyanide salts to accumulate and react with flowing water. Image credit: NASA/JPL-Caltech. That’s partly because no one researcher or laboratory can tackle all aspects of the problem. But recent experiments and simulations—studying planetary habitability, the conditions needed to produce biomolecules in the ratios and concentrations for self-sustaining metabolism, and the ways in which the precursors to DNA and RNA might have assembled and replicated—are beginning to answer some fundamental questions about the origin of life. Multiple labs are tackling these interdisciplinary challenges with myriad approaches. At least one team believes they might be on track to learn how life got a start on our planet. “For years, people working on the origin of life had many ideas but nothing that fell into place as a single working pathway,” says astronomer Dimitar Sasselov of Harvard University in Cambridge, …