The VIIRS instrument on the JPSS-2 (renamed NOAA-21 upon reaching orbit) spacecraft was launched in November 2022, making it the third sensor in the VIIRS series, following those onboard the SNPP and NOAA-20 spacecrafts, which are operating nominally. As a multi-disciplinary instrument, the VIIRS provides the worldwide user community with high-quality imagery and radiometric measurements of the land, atmosphere, cryosphere, and oceans. This study provides an early assessment of the calibration stability and radiometric consistency of the NOAA-21 VIIRS RSBs using the latest NASA SIPS C2 L1B products. Vicarious approaches are employed, relying on reflectance data obtained from the Libya-4 desert and Dome C sites, deep convective clouds, and simultaneous nadir overpasses, as well as intercomparison with the first two VIIRS instruments using MODIS as a transfer radiometer. The impact of existing band spectral differences on sensor-to-sensor comparison is corrected using scene-specific a priori hyperspectral observations from the SCIAMACHY sensor onboard the ENVISAT platform. The results indicate that the overall radiometric performance of the newly launched NOAA-21 VIIRS is quantitatively comparable to the NOAA-20 for the VIS and NIR bands. For some SWIR bands, the measured reflectances are lower by more than 2%. An upward adjustment of 6.1% in the gain of band M11 (2.25 µm), based on lunar intercomparison results, generates more consistent results with the NOAA-20 VIIRS.