Ramp is an important part of the interchange. The ramp design concept based on the running speed is a new design idea of the highway and interchange. By analysis of the influence factors of the interchange ramp running speed, this paper formulates the orthogonal experiment, and collects 14 ramps, in total of 147 groups of the running speed as the samples, and then analyzes the characteristics of the running speed of the vehicles on interchange ramp. According to the change trend of the running speed, the ramp is divided into three sections: deceleration section, uniform section, acceleration section. This paper mainly analyzes the relationship between the interchange ramp running speed of the three sections and the influence factors; and then this paper builds the interchange ramp running speed prediction model of the three sections. At last, correlation test will be validated, and verify the applicability of the model.