Title: Comparative analysis of the effect of adhesive systems on the microelement composition of the dentin of the crown part of the tooth. Purpose: To research the microelement composition of the «filling-tooth» interactive zone, the morphological characteristics of its border, to assess the effect of adhesive systems of the V and VII (self-etching) generations on the ion-exchange composition of the dentin of the crown part of the tooth, and to qualitatively assess the microelement composition of the hybrid dentin zone. Materials and methods: Extracted teeth with preserved crown part (n=20), enamel etching gel (Vladmiva), V generation Singlebond - 2 adhesive system (3M ESPE), self-etching adhesive system Prime-Bond Universal (Dentsply Sirona), light-cured composite material Migrofil (Republic of Belarus). The research of the microstructure of samples with formed and sealed Class I cavities according to Black was carried out on a certified high-resolution scanning electron microscope «Mira» by Tescan (Czech Republic). The research of the microelement composition of the «filling-tooth» border was carried out by X-ray spectral analysis, which consisted of 2 blocks: using the adhesive system of the fifth generation and the seventh generation of the adhesive system. Conclusions: 1. A comparative analysis of the results of using the fifth-generation adhesive system and the selfetching adhesive system showed that when using the total etching technique, trace elements Ca and P migrate from the tooth dentin structure into the hybrid zone. When using the adhesive system VII, the migration of elements was not established, due to the lack of demineralization of the dentin structure and the modification of the smeared layer. 2. Qualitative assessment of planar spectrograms revealed an increase in the carbon element in the modified adhesive layer. which is due to the presence of a smeared layer after odontopreparation of hard tissues of teeth destroyed by a carious process 3. The migration of the Si element indicates the chemical interaction of the adhesive and the filling material, as well as the filling material and the dentin of the tooth through the adhesive layer. 4. The use of the adhesive system of the fifth generation provides a higher quality of the marginal fit of the filling material to the surface of the dentin than when using a self-etching adhesive system.