Interaction Of Human Factors Research Articles

Elemental evolution characteristics and influencing factors of green infrastructure network in karst mountain cities: a case study of Qianzhong urban agglomeration in Southwest China

BackgroundThe urban green infrastructure (GI) network is an important conduit for ecological flows and plays a crucial role in improving regional habitats, especially in karst areas that are highly ecologically fragile and sensitive. However, the existing research only focuses on the construction of GI network in karst mountain cities, and the evolution characteristics of its elements and driving mechanism are not clear, which is of great significance for guiding urban land use planning and comprehensively improving the quality of the ecological environment. In view of this, this study took Qianzhong urban agglomeration as the study area, based on multi-source data, and identified ecological sources through ecological resilience analysis. Considering the special geographic environment, the rock exposure rate factor was added to correct the resistance surface, and the minimum cumulative resistance (MCR) and gravity model were coupled to extract the GI network. The complex network topology characterization parameter was introduced to assess the spatial and temporal variations of ecological sources and corridors. Finally, the geographical detector was used to identify the dominant influencing factors and interactions of the spatial distribution of the GI network.ResultsThe results showed that from 2000 to 2020, the condition of GI network elements in the study area presented a decreasing and then an increasing trend. The ecological sources or corridors in highly urbanized areas were critical for ecological flow transport and the overall structural stability of the GI network. The influence of natural factors on the spatial distribution of the GI network gradually weakened, and the influence of human factors continuously increased. The spatial distribution of the GI network was influenced by multiple factors, and the interaction between all the factors was enhanced, which gradually changed from the interaction of natural factors to the interaction of human factors during the study period.ConclusionsThe research results will provide scientific references for the construction of an ecologically safe environment and sustainable development of karst mountain cities.

Going beyond the means: Exploring the role of bias from digital determinants of health in technologies.

In light of recent retrospective studies revealing evidence of disparities in access to medical technology and of bias in measurements, this narrative review assesses digital determinants of health (DDoH) in both technologies and medical formulae that demonstrate either evidence of bias or suboptimal performance, identifies potential mechanisms behind such bias, and proposes potential methods or avenues that can guide future efforts to address these disparities. Mechanisms are broadly grouped into physical and biological biases (e.g., pulse oximetry, non-contact infrared thermometry [NCIT]), interaction of human factors and cultural practices (e.g., electroencephalography [EEG]), and interpretation bias (e.g, pulmonary function tests [PFT], optical coherence tomography [OCT], and Humphrey visual field [HVF] testing). This review scope specifically excludes technologies incorporating artificial intelligence and machine learning. For each technology, we identify both clinical and research recommendations. Many of the DDoH mechanisms encountered in medical technologies and formulae result in lower accuracy or lower validity when applied to patients outside the initial scope of development or validation. Our clinical recommendations caution clinical users in completely trusting result validity and suggest correlating with other measurement modalities robust to the DDoH mechanism (e.g., arterial blood gas for pulse oximetry, core temperatures for NCIT). Our research recommendations suggest not only increasing diversity in development and validation, but also awareness in the modalities of diversity required (e.g., skin pigmentation for pulse oximetry but skin pigmentation and sex/hormonal variation for NCIT). By increasing diversity that better reflects patients in all scenarios of use, we can mitigate DDoH mechanisms and increase trust and validity in clinical practice and research.

Conventional versus video-assisted laryngoscopy for perioperative endotracheal intubation (COVALENT) - a randomized, controlled multicenter trial

BackgroundData on the routine use of video-assisted laryngoscopy in peri-operative intubations are rather inconsistent and ambiguous, in part due to small populations and non-uniform outcome measures in past trials. Failed or prolonged intubation procedures are a reason for relevant morbidity and mortality. This study aims to determine whether video-assisted laryngoscopy (with both Macintosh-shaped and hyperangulated blades) is at least equal to the standard method of direct laryngoscopy with respect to the first-pass success rate. Furthermore, validated tools from the field of human factors will be applied to examine within-team communication and task load during this critical medical procedure.MethodsIn this randomized, controlled, three-armed parallel group design, multi-centre trial, a total of more than 2500 adult patients scheduled for perioperative endotracheal intubation will be randomized. In equally large arms, video-assisted laryngoscopy with a Macintosh-shaped or a hyperangulated blade will be compared to the standard of care (direct laryngoscopy with Macintosh blade). In a pre-defined hierarchical analysis, we will test the primary outcome for non-inferiority first. If this goal should be met, the design and projected statistical power also allow for subsequent testing for superiority of one of the interventions.Various secondary outcomes will account for patient safety considerations as well as human factors interactions within the provider team and will allow for further exploratory data analysis and hypothesis generation.DiscussionThis randomized controlled trial will provide a solid base of data in a field where reliable evidence is of major clinical importance. With thousands of endotracheal intubations performed every day in operating rooms around the world, every bit of performance improvement translates into increased patient safety and comfort and may eventually prevent significant burden of disease. Therefore, we feel confident that a large trial has the potential to considerably benefit patients and anaesthetists alike.Trial registrationClincalTrials.gov NCT05228288.Protocol version1.1, November 15, 2021.

Locked the Car, Why Not the Computer: A Qualitative and Quantitative Study on Data Safety Compliance.

Information technology has become an integral part of health care in the United Kingdom National Health Service (NHS). All health care professionals are required to have a certain level of cyber ethics and knowledge of computers. This is assured by regular mandatory training. The government of the United Kingdom has charted out a course to strengthen cyber security and prevent any crises like Wannacry. Simple things like leaving a computer unlocked can pose a potential threat to the cyber security of the whole NHS. These cannot be addressed with money alone, as they involve complex interactions of human factors. Such seemingly simple non-compliance results often in harm to the patient or breach of confidentiality. We tried to find out the compliance among junior doctors to the Trust Information Technology (IT) Safe Usage Policy. We made interventions and interviewed junior doctors to find out the reasons for non-compliance. We re-audited in order to see if our interventions helped. We also audited compliance in another Trust independently, which showed that this problem is not specific to a particular trust. Here we suggest the changes that all Trusts can make and follow our model to audit their compliance.

Compass for public/private management in turbulent times: corporate diplomacy

The 21st century is characterised by grand challenges, external shocks and global fragilities, such as economic volatility and societal upheaval in our interconnected communities. International business managers must adapt to consider geopolitics as relevant to their activities, to integrate political risk analyses into their business decisions. International society is in need of content-sensitive orientation knowledge to reassess, adjust and accommodate diplomacy's essentials (human factor interactions) to new expectations of the public sphere. In a qualitative leap towards a change of mindset, decision-makers should learn to think and act responsibly through the middle of conflictual situations towards compromise and consensus, thus managing politics through diplomacy. Transnational corporations can profit from traditional state diplomacy in order to create a reliable working environment and to anticipate and avoid costly conflicts, if they practice Corporate Diplomacy as a key concept of trusted and coordinated collaboration with government and local host communities. Corporations adhering to the diplomatic communication tool of Corporate Diplomacy are also gaining legitimacy and political influence over the development of societies.

Development of the contributing factors Framework interview guide (CFF-IG): All aboard the rail safety truth train

The Contributing Factors Framework (CFF) tool has been used by Australian railway operators since 2009 in order to assist in the identification of socio-technical and human factor interactions which contribute to rail safety accidents. Whilst the use of the CFF has been demonstrated to be a valuable tool for post-accident safety report analysis, an examination of how the CFF could be used as an interview guide for rail safety investigations immediately post-accident has previously not been explored.This study was therefore interested in firstly examining if the current CFF tool could be developed into an investigators’ interview guide and secondly if the resulting Contributing Factors Framework - Interview Guide (CFF-IG) would assist rail safety investigators to elicit better information on the contributing factors to rail safety accidents.The CFF-IG was therefore developed to elicit information across the original CFF tool’s three key main headings of Individual and Team Actions, Technical Failures and Local Conditions & Organisational Factors and was then applied to 18 rail safety accidents. The use of the CFF-IG by rail safety accident investigators was examined to assess its usefulness in establishing a consistent line of questioning relating to the identification of railway socio-technical accident contributing factors.It was found that the CFF-IG could be effectively applied at post-accident interviews and assisted investigators to identify an in-depth range of contributing factors to accidents in complex rail socio-technical systems.

Functionality of a novel follitropin alfa pen injector: Results from human factor interactions by patients and nurses

Functionality of a novel follitropin alfa pen injector: Results from human factor interactions by patients and nurses

Functionality of a novel follitropin alfa pen injector: Results from human factor interactions by patients and nurses

Functionality of a novel follitropin alfa pen injector: Results from human factor interactions by patients and nurses

Functionality of a novel follitropin alfa pen injector: results from human factor interactions by patients and nurses

ABSTRACTObjective: The main objective of this user experience testing study was to evaluate the impact of human factors on the use of a disposable pen containing follitropin alfa by patients and nurses with special focus on the convenience, safety and ease of use, in different types of stimulation protocols.Methods: Infertile women trying to conceive, and specialist nurses were recruited across 6 European countries. In total 18 patients and 19 nurses took part in the testing, which included both nurse-patient pairings and in-depth interviews. A standardized list of expected and pre-defined critical steps according to the Instructions for Use (IFU), was used to assess the correct handling of the pen.Results: During the user experience testing, no critical errors, related to the use of the pen, which could affect the success of the injection process were identified. In general, both nurses and patients found the pen very easy to learn, use and would be confident using the pen for self-injection. Nurses also found the pen very easy to train the patients.Conclusions: The study provides valuable information on the pen from both patient and nurse perspectives in different simulated scenarios reflecting standard practice.

Development of a BN framework for human reliability analysis through virtual simulation

Humans are an integral part of complex systems such as nuclear power plants and have to play a significant role in ensuring the safety and reliability of these systems. Failure to perform the intended task within the stipulated time by the operator can challenge the safety of the system. Human reliability analysis (HRA) is a widely practiced methodology to estimate the contribution of operator error towards the overall risk to the facility. HRA methods quantify this contribution in terms of human error probability (HEP) accounting for various psychological and physiological factors that influence the performance of the operator. These factors are referred to as human factors (HF), which enhance or degrade the human performance. The paper discusses the use of virtual simulation as a tool to generate the HF data from the virtual model of an in-house experimental facility. This paper also demonstrates the use of multi-attribute utility theory to determine a suitable HRA method amongst several HRA methods to quantify the HEP based on the desired set of HRA attributes. As classical HRA methods, generally, do not address the interactions among the HFs, the Bayesian network technique has been employed in this study to account for HF interactions.

Complexity analysis of the Next Gen Air Traffic Management System: trajectory based operations

According to Federal Aviation Administration traffic predictions currently our Air Traffic Management (ATM) system is operating at 150 percent capacity; forecasting that within the next two decades, the traffic with increase to a staggering 250 percent [17]. This will require a major redesign of our system. Today's ATM system is complex. It is designed to safely, economically, and efficiently provide air traffic services through the cost-effective provision of facilities and seamless services in collaboration with multiple agents however, contrary the vision, the system is loosely integrated and is suffering tremendously from antiquated equipment and saturated airways. The new Next Generation (Next Gen) ATM system is designed to transform the current system into an agile, robust and responsive set of operations that are designed to safely manage the growing needs of the projected increasingly complex, diverse set of air transportation system users and massive projected worldwide traffic rates. This new revolutionary technology-centric system is dynamically complex and is much more sophisticated than it's soon to be predecessor. ATM system failures could yield large scale catastrophic consequences as it is a safety critical system. This work will attempt to describe complexity and the complex nature of the NextGen ATM system and Trajectory Based Operational. Complex human factors interactions within Next Gen will be analyzed using a proposed dual experimental approach designed to identify hazards, gaps and elicit emergent hazards that would not be visible if conducted in isolation. Suggestions will be made along with a proposal for future human factors research in the TBO safety critical Next Gen environment.

Team training: implications for emergency and critical care pediatrics

The field of team training is quickly evolving and data are emerging to support the close relationship between effective teamwork and patient safety in medicine. This paper provides a review of the literature on team training with specific emphasis on the perspectives of emergency and critical care pediatricians. Errors in medicine are most frequently due to an interaction of human factors like poor teamwork and poor communication rather than individual mistakes. Critical care settings and those in which patients are at the extremes of age are particularly high-risk, making emergency and critical care pediatrics a special area of concern. Team training is one approach for reducing error and enhancing patient safety. Currently, there is no single standard for team training in medicine, but multiple disciplines, including anesthesiology, emergency medicine and neonatology, have adapted key principles from other high-reliability industries such as aviation into crisis resource management training. Team training holds promise to improve patient safety in pediatric emergency departments and critical care settings. We must carefully delineate the optimal instructional strategies to improve team behaviors and combine these with rigorous outcomes assessment to diagnose team problems and prescribe targeted solutions, and determine their long-term impact on patient safety.

7 Risk assessment and risk management in anaesthesia

The understanding of the basis of anaesthetic risk has changed from the concept of human error, to human factors interactions, to a system-oriented model. This model incorporates the importance of actions of individuals and organizational flaws. Risk control comprises risk prevention (assessment), avoidance (elimination) and reduction. The last of these requires a method for recognizing, managing and investigating untoward events. One such method is presented. Risk financing is the ability of organizations to pay for losses related to poor outcome. For anaesthetists, this represents fees for medical indemnity. Finally, the purpose of risk management, combined with quality assurance activities to ensure optimal patient care, is explained.

A Monoclonal Antibody to Factor VIII Inhibits von Willebrand Factor Binding and Thrombin Cleavage

To study the interaction of human factor VIII (FVIII) with its various ligands, select regions of cDNA encoding FVIII light chain were cloned into the plasmid expression vector pET3B to overproduce FVIII protein fragments in the bacterium Escherichia coli. Partially purified FVIII protein fragments were used to produce monoclonal antibodies. One monoclonal antibody, 60-B, bound both an FVIII protein fragment (amino acid residues 1563 through 1909) and recombinant human FVIII, but not porcine FVIII. This antibody prevented FVIII-vWF binding and acted as an inhibitor in both the activated partial thromboplastin time (APTT) assay and a chromogenic substrate assay that measured factor Xa generation. The ability of the antibody to inhibit FVIII activity was diminished in a dose-dependent fashion by von Willebrand factor. This anti-FVIII monoclonal antibody bound to a synthetic peptide, K E D F D I Y D E D E, equivalent to FVIII amino acid residues 1674 through 1684. The 60-B antibody did not react with a peptide in which the aspartic acid residue at 1681 (underlined) was changed to a glycine, which is the amino acid present at this position in porcine FVIII. Gel electrophoretic analysis of thrombin cleavage patterns of human FVIII showed that the 60-B antibody prevented thrombin cleavage at light chain residue 1689. The coagulant inhibitory activity of the 60-B antibody may be due, in part, to the prevention of thrombin activation of FVIII light chain.

A monoclonal antibody to factor VIII inhibits von Willebrand factor binding and thrombin cleavage

To study the interaction of human factor VIII (FVIII) with its various ligands, select regions of cDNA encoding FVIII light chain were cloned into the plasmid expression vector pET3B to overproduce FVIII protein fragments in the bacterium Escherichia coli. Partially purified FVIII protein fragments were used to produce monoclonal antibodies. One monoclonal antibody, 60-B, bound both an FVIII protein fragment (amino acid residues 1563 through 1909) and recombinant human FVIII, but not porcine FVIII. This antibody prevented FVIII-vWF binding and acted as an inhibitor in both the activated partial thromboplastin time (APTT) assay and a chromogenic substrate assay that measured factor Xa generation. The ability of the antibody to inhibit FVIII activity was diminished in a dose-dependent fashion by von Willebrand factor. This anti-FVIII monoclonal antibody bound to a synthetic peptide, K E D F D I Y D E D E, equivalent to FVIII amino acid residues 1674 through 1684. The 60-B antibody did not react with a peptide in which the aspartic acid residue at 1681 (underlined) was changed to a glycine, which is the amino acid present at this position in porcine FVIII. Gel electrophoretic analysis of thrombin cleavage patterns of human FVIII showed that the 60-B antibody prevented thrombin cleavage at light chain residue 1689. The coagulant inhibitory activity of the 60-B antibody may be due, in part, to the prevention of thrombin activation of FVIII light chain.

The interactions of factors X and IX with phospholipid

The interactions of human factors X and IX with phospholipid were studied with an ELISA system. In the presence of calcium ions, factor X bound to phosphatidylserine with an affinity of 1.56 × 10 10 M −1 and to phosphatidylcholine with an affinity of 5.6 × 10 9 M −1. In the presence of calcium ions, factor IX bound to phosphatidylserine with an affinity of 8.4 × 10 8 M −1 and no binding to phosphatidylcholine was observed. No competition of factors X and IX for phosphatidylserine binding sites was observed.

An Overview of Literature on Human Factors and Part-task Training with Implications for Visual Simulation in Primary Flight Training

Research issues are identified through the application of a conceptual model of human factors interactions in pilot perfonnance. The application of part- task training concepts and methodology shows that simulation has a great potential to address pilot training research design issues. This and new technologies indicate that the best medium for the cost effective application of part-task training methodology would be a computer generated video graphics display. The U.S. college and university aviation programs have all the ingredients on hand to develop this training device and the best minds with which to do it. Appendices hold collections of references for those interested in these subjects.

Binding of native and thrombin activated factor VIII to platelets

The interaction of human Factor VIII with platelets has been studied using discontinuous albumin gradient centrifugation. When purified Factor VIII complex was mixed with released platelets about 10% of the recovered Factor VIII activity became associated with the platelets. In the corresponding experiment with thrombin-activated Factor VIII about half of the Factor VIII activity was bound to the platelets. This binding was reversible; dilution of the platelet suspension containing bound Factor VIII resulted in dissociation of part of the Factor VIII activity. With non-released platelets very little binding of Factor VIII activity occured. A mechanism for the in vivo formation of the Factor X activator complex is suggested.