Interaction Effects Of Sex Research Articles

Investigation of the relationship of apelin hormone response with some physiological parameters in Maedi-Visna infected sheep

In this study, the objective was to assess the serological characteristics of sheep, during lactation and pregnancy periods, and rams belonging to the Red Karaman and White Karaman–Kangal race infected with maedi-visna infection and body condition score (BCS) of ≤2, 3- 3.5 and ≥4 (high) and to analyse the relationship between the level of apelin and its secretion. Apelin level in the blood serum samples obtained from the jugular veinof the sheeps was determined using ELISA method. As a result of the analyses, it was determined that the level of apelin was statistically different between the races; between lactating sheep and pregnant sheep; and sheep and rams. There was no difference between the BCS groups (p > 0.05). Race and sex interaction as well as race, sex and BCS triple interaction effects were found significant (p < 0.05). It was observed that the sheep belonging to the White Karaman–Kangal race were 18 times more likely to be infected with the virus. A decrease in apelin level was observed in the sheep with infection, and it was found that the risk of infection was 0.37 times higher in rams than in lactating sheep (p < 0.05).

Influence of Sex and Acute Beetroot Juice Supplementation on 2 KM Running Performance

Purpose: To assess the effect of acute nitrate-rich (BJ) and nitrate-depleted (PL) beetroot juice ingestion on 2 km running performance in amateur runners, and to what extent the ergogenic effect of BJ supplementation would be influenced by the sex of the participants; Methods: Twenty-four amateur long-distance runners (14 males and 10 females) performed a 2 km time trial (TT) on an outdoor athletics track 2.5 h after ingesting either 140 mL of BJ (~12.8 mmol NO3−) or PL. After the tests, blood [lactate] and ratings of perceived exertion (RPE) related to the leg muscles (RPEmuscular), cardiovascular system (RPEcardio) and general overall RPE (RPEgeneral) were assessed; Results: Compared to PL, BJ supplementation improved 2 km TT performance in both males (p < 0.05) with no supplement × sex interaction effect (p > 0.05). This improvement in 2 km running performance was a function of improved performance in the second 1 km split time in both males and females (p < 0.05). Supplementation with BJ did not alter post-exercise blood [lactate] (p > 0.05) but lowered RPEgeneral (p < 0.05); Conclusions: acute BJ supplementation improves 2 km running performance in amateur runners by enhancing performance over the second half of the TT and lowering RPEgeneral by a comparable magnitude in males and females.

Breast meat quality in males and females of fast-, medium- and slow-growing chickens fed diets of 2 protein levels

The aim of this study was to evaluate the effects of genotype, sex, dietary protein level, and their interactions on select carcass characteristics and meat quality of fast- (Ross 308), medium- (Hubbard JA757) and slow-growing (ISA Dual) chickens (n = 2,520). The diet of the low-protein group of chickens had 6% lower CP than the commercial diet fed to the control group. When the chickens reached an average live weight of 2 kg, 10 males and 10 females of each genotype and the diet were selected for slaughter and breast meat–quality analysis. The dressing out and breast percentages were lower in the JA757 (−2.0 and −5.9%, respectively) and ISA Dual chickens (−9.9 and −14.3%, respectively) than those in the Ross 308 chickens. The ISA Dual chickens had higher abdominal fat percentage, higher DM and protein contents and lower ether extract content and shear force value in breast meat than the other genotypes. Significant interaction effects of genotype, sex, and diet were found on the color of breast skin. Among the various combinations of genotype, sex, and diet group, Ross 308 females fed the low-protein diet had the highest redness and yellowness of breast skin, highest pH45 value, and largest fibers, whereas ISA Dual females had the lowest color parameters and pH45 value, and ISA Dual males had the smallest muscle fibers. The low-protein diet was associated with decreased abdominal fat percentage and changes in meat quality parameters, including increased darkness, meat color intensity, drip loss, and muscle fiber area, in all genotypes. The results indicated greater differences in meat quality owing to genotype than to sex or dietary protein level.

Self-Reported Screen Time on Social Networking Sites Associated With Problematic Smartphone Use in Chinese Adults: A Population-Based Study.

Background: Problematic smartphone use (PSU) has been associated with screen time in general, but little is known about the effect of different screen-based activities. We examined the associations of self-reported time spent on overall and specific screen-based activities with PSU and its addictive symptoms in Hong Kong Chinese adults.Methods: We analyzed data from 562 smartphone owners (56.5% female; 82.1% aged 25–64 years) in a population-based telephone survey in 2017. PSU was measured using Smartphone Addiction Scale-Short Version (range 10–60) which includes symptoms of daily-life disturbance, withdrawal, cyberspace-oriented relationship, overuse, and tolerance. Screen time was self-reported as average hours per day spent on the internet, online book/newspaper/magazine, online video, and social networking sites (SNS). Multivariable linear regression analyzed the associations of self-reported screen time with PSU severity and symptoms. Interaction effects of sex, age group, educational attainment, and monthly household income were examined.Results: Self-reported time spent on overall screen-based activities was associated with PSU severity (β = 1.35, 95% CI 0.15, 2.55) and withdrawal and overuse symptoms, after adjusting for sociodemographic and health-related variables. Independent association was observed for self-reported SNS time with PSU severity (β = 1.42, 95% CI 0.35, 2.49) and symptoms of withdrawal and cyberspace-oriented relationship, after mutually adjusting for time on other activities. The strongest association between self-reported SNS time and PSU severity was observed in younger than older adults (β = 4.36, 95% CI 2.58, 6.13; P for interaction = 0.004).Conclusions: The independent association of self-reported SNS time with PSU and core addictive symptoms highlighted the addiction potential of SNS use, particularly in younger users.

Sex-related human brain asymmetry in hemispheric functional gradients

The left and right hemispheres of the human brain are two connected but relatively independent functional modules; they show multidimensional asymmetries ranging from particular local brain unit properties to entire hemispheric connectome topology. To date, however, it remains largely unknown whether and how hemispheric functional hierarchical structures differ between hemispheres. In the present study, we adopted a newly developed resting-state (rs) functional connectivity (FC)-based gradient approach to evaluate hemispheric functional hierarchical structures and their asymmetries in right-handed healthy young adults. Our results showed an overall mirrored principal functional gradient between hemispheres, with the sensory cortex and the default-mode network (DMN) anchored at the two opposite ends of the gradient. Interestingly, the left hemisphere showed a significantly larger full range of the principal gradient in both males and females, with males exhibiting greater leftward asymmetry. Similarly, the principal gradient component scores of two regions around the middle temporal gyrus and posterior orbitofrontal cortex exhibited similar hemisphere × sex interaction effects: a greater degree of leftward asymmetry in males than in females. Moreover, we observed significant main hemisphere and sex effects in distributed regions across the entire hemisphere. All these results are reproducible and robust between test-retest rs-fMRI sessions. Our findings provide evidence of functional gradients that enhance the present understanding of human brain asymmetries in functional organization and highlight the impact of sex on hemispheric functional gradients and their asymmetries.

Effect of genotype and sex on growth traits, feed utilization and survivability in Nigerian local and Nicholas white exotic turkey

Two hundred (200) Nigerian local and Nicholas white (NW) exotic poults (hundred for each breed) were observed from day old to fifteen week for growth traits [Body Weight (BW) and linear body measurements; Body Length (BL), Body Girth (BG), Shank Length (SL) Shank Diameter (SD), Thigh Length (TL), Wing length (WL)], survivability and feed utilization potential (feed intake and feed conversion ratio). There was a significant (p<0.05) genotype effect on BW throughout the experimental period, BW ranged from 120.41± 3.12 to 2764.00±32.10g and 142.29±2.94 to 4601.00±41.45g in Nigerian local and NW exotic turkey respectively. Sex effect and interaction between genotypes and sex (GxS) on bodyweight were significant (p<0.05) between weeks 7 to 15. Genotypes, sex and GxS effects were also significant (p<0.05) on linear body parameters measured at different ages. Feed intake and feed conversion ratio for the two genotypes were significantly (p<0.05) different. The NW exotic consumed more feed than the local turkey (14.29 to 250.31g vs. 13.27 to 200.47g) from week 1 to 15. The Nigerian local poults significantly (p<0.04) had better feed conversion ratio (FCR) from week 1 to 7 (0.17 to 0.21) than the NW exotic (0.20 to 0.23). However, as the poults grow older (from week 8 to 15), the NW exotic had better FCR (0.24 to 0.31) compared to the Nigerian local (0.27 to 0.38).Mortality rate was higher in the NW exotic (25%) than the Nigerian local turkey during the study period. This research showed significant genotype, sex and GxS interaction effects on growth traits of turkey. It showed that the NW exotic poults consumed more feed and gained more weight than the Nigerian local from week 1 to 15, had better feed conversion ratio and poorer survivability at older ages (weeks 8 to 15). The Nigerian local consumed smaller quantity of feed and had better FCR at poults stage (weeks 1 to 7). The Nigerian local turkey had better survivability rate throughout the experimental period and can be selected for an improved body weight and better feed utilization at early stage of life.

Sex differences in structural brain asymmetry of children with autism spectrum disorders

Previous studies have confirmed the sex difference of gray matter asymmetry in typically developing controls and the abnormal gray matter asymmetry in autism spectrum disorders. However, whether and how sex differences of gray matter asymmetry exist in autism spectrum disorders remains studied. This paper analyzes the above issues and explores correlations between gray matter asymmetry and autistic symptoms. Data from 72 children (36 males and 36 females) with autism spectrum disorders and 72 typically developing-controls (36 males and 36 females) between 8 and 14 years were included and obtained from the autism brain imaging data exchange repository (autism brain imaging data exchange I and autism brain imaging data exchange II). The voxel-based morphometry approach was used to assess gray matter asymmetry in T1-weighted brain data, and gray matter asymmetry was quantified as asymmetry index. A 2 × 2 analysis of covariance was used to identify asymmetry index differences among the four groups. Pearson correlation analysis was performed for asymmetry index values extracted from the clusters with significant differences between the four groups and autistic symptoms (social impairments, communication difficulties, and restricted, repetitive behaviors) measured by the revised autism diagnostic interview scale. Results showed that specific brain regions showed significant main effects for diagnosis in which autism spectrum disorders patients had more leftward asymmetry than typically developing-controls for the parahippocampal gyrus and the postcentral gyrus; specific brain regions showed significant main effects for sex in which females showed more rightward asymmetry for the middle temporal gyrus, inferior frontal gyrus, angular gyrus, and postcentral gyrus and minor rightward asymmetry for the superior frontal gyrus than males; significant diagnosis × sex interaction effects were identified in the angular gyrus and middle occipital gyrus. Pearson correlation analysis showed that males with autism spectrum disorders had a positive association between the asymmetry index value in the middle occipital gyrus and more significant verbal impairment measured by the revised autism diagnostic interview (r = 0.387, p = 0.026). The asymmetry index value in the parahippocampal gyrus was positively associated with more severe social impairment in females with autism spectrum disorders (r = 0.422, p = 0.020). We identified that the sex difference of gray matter asymmetry in children with autism spectrum disorders is qualitative rather than quantitative, which is relatively novel. Our findings provide the theoretical basis for conducting separate studies and using sex-specific diagnostic methods and treatments for males and females children with autism spectrum disorders.

Comparison of basal whole-body protein kinetics and muscle protein synthesis between young and older adults.

Significant research has been dedicated to counteracting age‐related muscle loss, but underlying mechanisms have not been clearly established. Previous research examining differences in basal protein kinetics between young and older individuals has been limited by a lack of evaluation of protein breakdown and net balance. The aim of this study was to more comprehensively examine differences in basal protein kinetics between younger and older males and females. Basal whole‐body protein kinetics and muscle fractional synthetic rate (FSR) from 91 younger (18–38 years; 52% female) and 66 older (51–81 years; 53% female) healthy adults were determined using stable isotope tracer techniques (L‐[ring‐2H5]phenylalanine and L‐[ring‐2H2]tyrosine). There were no group × sex interaction effects (p > .05). Older individuals had greater whole‐body protein synthesis (mean difference old‐young (Δ) ± SE: 28.54 ± 8.15 mg/kg LBM/hr; p = .001) and breakdown (Δ: 15.44 ± 7.33 mg/kgLBM/hr; p = .038), but a less negative net balance (Mean ± SD: Young: −31.22 ± 7.42 mg/kg LBM/hr; Old: −18.11 ± 21.60 mg/kg LBM/hr; p < .001) compared to young individuals. Basal FSR was not significantly different between young and older (Δ: 0.007 ± 0.003%/hr; p = .052). Across the age range, females had greater whole‐body protein turnover (PSΔ: 19.10 ± 7.00 mg/kgLBM/hr; PBΔ: 19.22 ± 6.31 mg/kgLBM/hr; p < .01) compared to males. Results demonstrate a difference in basal whole‐body protein kinetics between young and older adults, with older adults having a higher protein turnover rate and a less negative net balance. Across the age range, females were also found to have a higher turnover rate compared to males. Differences may represent a shift in older physiology toward mechanisms that increase the efficiency of amino acid reutilization, especially in women.

Brain PUFA Concentrations Are Differentially Affected by Interactions of Diet, Sex, Brain Regions, and Phospholipid Pools in Mice

PUFAs play vital roles in the development, maintenance, and functioning of circuitries that regulate reward and social behaviors. Therefore, modulations in PUFA concentrations of these brain regions may disrupt reward and social circuitries contributing to mood disorders, developmental disabilities, and addictions. Though much is known about regional and phospholipid-pool-specific PUFA concentrations, less is known about the effects of dietary interventions that concurrently lowers n-6 PUFA and supplements n-3 PUFA, on brain PUFA concentrations. There is even less knowledge on the effects of sex on brain PUFA concentrations. This study aimed to comprehensively examine the interaction effects of diet (D), sex (S), brain regions (BR), and phospholipid pools (PL) on brain PUFA concentrations. Male and female C57BL/6J mice were fed 1 of 4 custom-designed diets varying in linoleic acid (LNA) (8en% or 1 en%) and eicosapentaenoic acid/docosahexaenoic acid (EPA/DHA) (0.4 en% or 0 en%) concentrations from in utero to 15 weeks old. At 15 weeks old, the prefrontal cortex, dorsal striatum, and cerebellum were collected. Fatty acids of 5 major PL were quantified by GC-flame ionization detection. Repeated measures ANOVA was used to test for differences among the groups for D, S, BR, and PL. No significant 4-way interactions on PUFA concentrations. DHA, predominant n-3 PUFA, concentrations were dependent on significant D × BR × PL interactions. DHA concentration was not affected by sex. Arachidonic acid (ARA; predominant n-6 PUFA) concentrations were not dependent on 3-way interactions. However, significant 2-way D × PL, BR × PL, and D × Sinteractions affected ARA concentrations. Brain fatty acid concentrations were differentially affected by various combinations of D, S, BR, and PL interactions. Though DHA concentrations are not affected by sex, ARA concentrations are affected by interactions of the 4 variables examined. This study provides comprehensive references in the investigation of complex interactions between factors that affect brain PUFA concentrations in mice.

Sex-specific associations of asthma acquisition with changes in DNA methylation during adolescence.

Underlying biological mechanisms involved in sex differences in asthma status changes from pre- to post-adolescence are unclear. DNA methylation (DNAm) has been shown to be associated with the risk of asthma. We hypothesized that asthma acquisition from pre- to post-adolescence was associated with changes in DNAm during this period at asthma-associated cytosine-phosphate-guanine (CpG) sites and such an association was sex-specific. Subjects from the Isle of Wight birth cohort (IOWBC) with DNAm in blood at ages 10 and 18years (n=124 females, 151 males) were studied. Using a training-testing approach, epigenome-wide CpGs associated with asthma were identified. Logistic regression was used to examine sex-specific associations of DNAm changes with asthma acquisition between ages 10 and 18 at asthma-associated CpGs. The ALSPAC birth cohort was used for independent replication. To assess functional relevance of identified CpGs, association of DNAm with gene expression in blood was assessed. We identified 535 CpGs potentially associated with asthma. Significant interaction effects of DNAm changes and sex on asthma acquisition in adolescence were found at 13 of the 535 CpGs in IOWBC (P-values <1.0×10-3 ). In the replication cohort, consistent interaction effects were observed at 10 of the 13 CpGs. At 7 of these 10 CpGs, opposite DNAm changes across adolescence were observed between sexes in both cohorts. In both cohorts, cg20891917, located on IFRD1 linked to asthma, shows strong sex-specific effects on asthma transition (P-values <.01 in both cohorts). Gender reversal in asthma acquisition is associated with opposite changes in DNAm (males vs females) from pre- to post-adolescence at asthma-associated CpGs. These CpGs are potential biomarkers of sex-specific asthma acquisition in adolescence.

Effects of a Combined Endurance/Strength Training Program on Circulating Irisin Levels in Overweight/Obese Men and Women with Type 2 Diabetes Mellitus.

Irisin is a promising therapeutic target in patients with type 2 diabetes mellitus (T2DM), as studies have demonstrated that irisin can induce "browning" of adipocytes and mitigate pro-inflammatory conditions. Sex-specific changes in irisin levels have been reported in a study involving healthy men and women following physical training. The present study aims to analyze the effects of an 8-week training intervention on circulating irisin levels in patients with T2DM and to find out whether the training responses differ between T2DM men and women. Twenty-nine overweight/obese T2DM patients (19 men, 10 women; age: 46-74 years; body mass index >25 kg/m2) participated in a combined moderate-intensity endurance/strength training program (3 times a week). The irisin levels of men and women did not differ significantly. The post-training irisin levels did not differ significantly from the pre-training values, and there was no interaction effect of sex. This study shows no training-induced (sex-specific) changes in circulating irisin levels in T2DM patients. Large-scale studies using other forms of training are needed to fully clarify whether basal irisin levels can be changed in T2DM men and/or women to counteract T2DM.

Seasonal Changes in Anthropometry, Body Composition, and Physical Fitness and the Relationships with Sporting Success in Young Sub-Elite Judo Athletes: An Exploratory Study.

This exploratory study aimed to monitor long-term seasonal developments in measures of anthropometry, body composition, and physical fitness in young judo athletes, and to compute associations between these measures and sporting success. Forty-four young judoka (20 females, 24 males) volunteered to participate. Tests for the assessment of anthropometry (e.g., body height/mass), body-composition (e.g., lean body mass), muscle strength (isometric handgrip strength), vertical jumping (e.g., countermovement-jump (CMJ) height), and dynamic balance (Y-balance test) were conducted at the beginning and end of a 10-month training season. Additionally, sporting success at the end of the season was recorded for each athlete. Analyses revealed significant time × sex interaction effects for lean-body-mass, isometric handgrip strength, and CMJ height (0.7 ≤ d ≤ 1.6). Post-hoc analyses showed larger gains for all measures in young males (1.9 ≤ d ≤6.0) compared with females (d = 2.4) across the season. Additionally, significant increases in body height and mass as well as Y-balance test scores were found from pre-to-post-test (1.2 ≤ d ≤4.3), irrespective of sex. Further, non-significant small-to-moderate-sized correlations were identified between changes in anthropometry/body composition/physical fitness and sporting success (p > 0.05; −0.34 ≤ ρ ≤ 0.32). Regression analysis confirmed that no model significantly predicted sporting success. Ten months of judo training and/or growth/maturation contributed to significant changes in anthropometry, body composition, and physical fitness, particularly in young male judo athletes.

Racial differences in gait mechanics

The effect of race has rarely been investigated in biomechanics studies despite racial health disparities in the incidence of musculoskeletal injuries and disease, hindering both treatment and assessment of rehabilitation. The purpose of this study was to test the hypothesis that racial differences in gait mechanics exist between African Americans (AA) and white Americans (WA). Ninety-two participants (18–30 years old) were recruited with equal numbers in each racial group and sex. Self-selected walking speed was measured for each participant. 3D motion capture and force plate data were recorded during 7 walking trials at regular and fast set speeds. Step length, step width, peak vertical ground reaction force, peak hip extension, peak knee flexion, and peak ankle plantarflexion were computed for all trials at both set speeds. Multivariate and post-hoc univariate ANOVA models were fit to determine main and interaction effects of sex and race (SPSS V26, α = 0.05). Self-selected walking speed was slower in AA (p = 0.004, ƞp2 = 0.088). No significant interactions between race and sex were identified. Males took longer steps (regular: p < 0.001, ƞp2 = 0.288, fast: p < 0.001, ƞp2 = 0.193) and had larger peak knee flexion (regular: p = 0.007, ƞp2 = 0.081, fast: p < 0.001, ƞp2 = 0.188) and ankle plantarflexion angles (regular: p = 0.050, ƞp2 = 0.044, fast: p = 0.049, ƞp2 = 0.044). Peak ankle plantarflexion angle (regular: p = 0.012, ƞp2 = 0.071, fast: p < 0.001, ƞp2 = 0.137) and peak hip extension angle during fast walking (p = 0.007, ƞp2 = 0.083) were smaller in AA. Equivalency in gait measures between racial groups should not be assumed. Racially diverse study samples should be prioritized in the development of future research and individualized treatment protocols.

Sex differences in brain metabolites in anxiety and mood disorders

Gender differences in mood and anxiety disorders are well-established. However, the neural basis of these differences is not clear yet, especially in terms of brain metabolism. Indeed, although several proton Magnetic Resonance Spectroscopy (¹H MRS) investigations reported different metabolic levels in both depression and anxiety disorders, which have been also linked to symptoms severity and response to treatment, the role of gender on these differences have not been explored yet. Therefore, this study aims at investigating the role of sex in neurometabolic alterations associated with both mood and anxiety disorders. A 3T single-voxel ¹H MRS acquisition of the dorsolateral prefrontal cortex was acquired from 14 Major Depressive Disorder, 10 Generalized Anxiety Disorder (GAD), 11 Panic Disorder (PD), patients and 16 healthy controls (HC). Among males, PD patients showed significantly lower GPC+PC (also observed in GAD+PD) and Glu levels compared to HC. Finally, a significant group x sex interaction effect was observed in the GPC+PC and Glu levels. We proved the presence of an association between sex and brain metabolites in anxiety spectrum.

Physical activity in early adolescence predicts depressive symptoms 3 years later: A community-based study

BackgroundPhysical activity (PA) during adolescence is associated with a wide range of health benefits, including lower levels of internalizing and externalizing problems. Although the association between PA and mental health has been established, there are few prospective studies investigating if the association between PA and internalizing/externalizing symptoms remains after adjustment for the baseline occurrence of such symptoms, and those exploring any sex-specific pattern of the association. MethodsSwedish adolescents (N = 1428; mean age = 14.38 years) were assessed and followed up 3 years later. Self-reported data were collected for PA (recoded as low, moderate and high levels), internalizing (depression and anxiety) and externalizing (attention-deficit/hyperactivity disorder and disruptive behaviours) symptoms. A full path analysis was used to determine the main and interaction effects of PA and sex on internalizing/externalizing symptoms 3 years later, adjusting for these symptoms at baseline. ResultsHigher levels of PA were correlated with lower internalizing/externalizing symptoms. In the full path analysis, PA during early adolescence predicted lower levels of depressive symptoms, but not anxiety or externalizing problems, 3 years later. A sex-specific effect of PA on depressive symptoms was found, wherein boys, but not girls, with high levels of PA showed reduced symptoms. LimitationsIncluding parental ratings, diagnostic assessments and objective measures of PA would have provided additional information to the study. ConclusionsLow levels of PA during early adolescence are a unique predictor for the development of depressive symptoms among boys. PA should be considered when discussing prevention and treatment for depression in adolescents.

Delayed Cerebral Ischemia After Aneurysmal Subarachnoid Hemorrhage in Patients With a History of Migraine.

Delayed cerebral ischemia (DCI) is a major contributor to the high morbidity in patients with aneurysmal subarachnoid hemorrhage (aSAH). Spreading depolarizations may play a role in DCI pathophysiology. Because patients with migraine are probably more susceptible to spreading depolarizations, we investigated whether patients with aneurysmal subarachnoid hemorrhage with migraine are at increased risk for DCI. We included patients with aneurysmal subarachnoid hemorrhage from 3 hospitals in the Netherlands. We assessed lifetime migraine history with a short screener. DCI was defined as neurological deterioration lasting >1 hour not attributable to other causes by diagnostic work-up. Adjustments were made for possible confounders in multivariable Cox regression analyses and adjusted hazard ratios (aHR) were calculated. We assessed the interaction effects of age and sex. We included 582 patients (mean age 57 years, 71% women) mostly with mild to moderate aneurysmal subarachnoid hemorrhage of whom 108 (19%) had a history of migraine (57 with aura). Patients with migraine were not at increased risk of developing DCI compared with patients without migraine (22% versus 24%, aHR, 0.89 [95% CI, 0.56-1.43]). Additionally, no increased risk was found in patients with migraine with possible aura (aHR, 0.74 [95% CI, 0.39-1.43]), in women (aHR, 0.88 [95% CI, 0.53-1.45], Pinteraction=0.859), or in young patients aged <50 years (aHR, 1.59 [95% CI, 0.72-3.49]), although numbers in these subgroups were limited. We found an interaction between migraine and age with an increased risk of DCI among young patients with migraine (Pinteraction=0.075). Patients with migraine are in general not at increased risk of DCI. Future studies should focus in particular on young SAH patients, in whom there might be an association between migraine history and development of DCI.

Sex and mechanism of injury influence knee joint loading symmetry during gait 6 months after ACLR.

Early-onset knee osteoarthritis (OA) is associated with gait asymmetries after anterior cruciate ligament reconstruction (ACLR). Women have higher risks of sustaining non-contact injuries, and are more likely to present with aberrant movement patterns associated with the mechanism of injury (MOI). We hypothesized that sex and MOI would influence gait after ACLR. Seventy participants, grouped by sex and MOI, completed biomechanical testing during over-ground walking when they had full knee range of motion, trace or less knee effusion, greater than 80% quadriceps strength limb symmetry index, ability to hop on each leg without pain, and initiated running. Bilateral knee kinetics, kinematics, and joint contact forces were compared using mixed-model analysis of variance (α = .05). There was a three-way interaction effect of sex × MOI × limb for peak medial compartment contact force (P = .002), our primary outcome measure previously associated with OA development. Men with non-contact injuries walked with asymmetry characterized by underloading of the involved limb. Men with contact injuries walked with the most symmetrical loading. In women, no clear pattern emerged based on MOI. Targeting, and possibly prioritizing interventions for athletes who present with gait asymmetries after ACLR based on sex and MOI, may be necessary to optimize outcomes. Statement of Clinical Significance: Sex and MOI may influence walking mechanics, and could be considered in future interventions to target gait symmetry, as a response to interventions may vary based on differences in sex and MOI.

Physical activity and perceived benefits, but not barriers, to exercise differ by sex and school year among college students

Objective To assess whether sex or school year influence physical activity and exercise (PA/EX) behaviors and perceived benefits and barriers of PA/EX among college students. Participants: Participants were 862 (78% female; 20.1 ± 1.4 years) college students. Methods: The International Physical Activity Questionnaire, Exercise Benefits and Barriers Scale, and resistance training (RT) questions were completed online. Results: Factorial ANOVA (sex x year) determined no significant interaction effects of sex and school year in behaviors or perceived benefits and barriers (all p > .05). Males reported higher levels of PA/EX and RT than females (p < .05) with no differences by school year (p = .34). Benefits Scale scores and some of its subscales were higher for males and first-year students compared to females and third- and fourth-year students (all p < .05). Conclusion: PA/EX promotion programs may need to be tailored differently based on sex and school year.

Does Sex Impact the Differences and Relationships in the One Repetition Maximum Performance Across Weightlifting Overhead Pressing Exercises?

Soriano, MA, García-Ramos, A, Calderbank, J, Marín, PJ, Sainz de Baranda, P, and Comfort, P. Does sex impact the differences and relationships in the one repetition maximum performance across weightlifting overhead pressing exercises? J Strength Cond 36(7): 1930-1935, 2022-This study aimed to determine the impact of sex on the differences and relationships of the one repetition maximum (1RM) performance between 3 overhead pressing exercises (push press [PP], push jerk [PJ] and split jerk [SJ]). 15 men (body mass [BM]: 82.3 ± 9.9 kg; weightlifting training experience: 2.6 ± 1.6 years) and 15 women (BM: 64.4 ± 7.0 kg; weightlifting training experience: 2.2 ± 1.4 years) participated in this study. A ratio-scaled (1RM·BM-1) was used for the comparison between them. The 1RM of the 3 exercises were evaluated within the same testing session using a combined 1RM assessment method. The interaction effect of exercise and sex did not reach statistical significance (p = 0.671; η2 = 0.001). In contrast, there were significant main effects of exercise (p ≤ 0.01) and sex (p < 0.001) with medium (η2 = 0.096) and large effect sizes (η2 = 0.306), respectively. A similar main effect of exercise was reported for both men (PP [1.0 ± 0.1 kg·kg-1] < PJ [1.1 ± 0.2 kg·kg-1] ∼ SJ [1.2 ± 0.2 kg·kg-1]) and women (PP [0.8 ± 0.1 kg·kg-1] < PJ [0.9 ± 0.2 kg·kg-1] ∼ SJ [0.9 ± 0.2 kg·kg-1]). The 1RM performance of the 3 exercises was significantly correlated for men (r [range] = 0.856-0.963) and women (r [range] = 0.636-0.925). Sex does not affect the differences in the 1RM performance across weightlifting overhead pressing exercises. However, stronger correlations and lower variation in the 1RM performance during the PP, PJ, and SJ are expected for men compared with women.

Interaction Effect of Sex on Cognitive Behaviour Therapy and Logotherapy in Reducing Risky Sexual Behaviours among School Adolescents

This study investigated the interaction effect of sex on cognitive behaviour therapy and logotherapy on risky sexual behaviours among adolescents, in public secondary schools in Benin metropolis, Edo State, Nigeria. The study adopted a quasi-experimental design, using pre-test—post-test, non-equivalent control grous. The population of the study comprised of SS II students in the Thirty-one (31) mixed public senior secondary schools in Benin Metropolis. The sample of the study consisted of one hundred and thirty-five (135) Senior Secondary Two (SSII) students. The study adapted the “Adolescent Sex Behaviour Inventory’’ developed by Friedrich (2004). The instrument was validated while the reliability coefficient of 0.926 was established. The collected data were analysed, using descriptive and inferential statistics. The findings of the study revealed that there is significant difference in the treatment interaction by sex in reducing risky sexual behaviours among school adolescents. Therefore, it was concluded that sex could play a role in the reduction of risky sexual behaviours among school adolescents. Based on the findings, it was recommended that school counsellors should encourage parents to give sex education early and discuss sex-related issues that are appropriate for their children in all stages to avoid the consequences of risky sexual behaviours.