Abstract In this paper, simulative analysis and performance comparison of different EDFA (Erbium-doped fiber amplifier) configurations in a 10 Gbps inter-satellite optical wireless communication (IsOWC) link have been reported for a 5,000 km long link and 1,550 nm operating wavelength. The results show that system in which both pre-amplifier and booster amplifier stages are implemented simultaneously outperforms systems with only pre-amplifier and booster amplifier stage. From the results, it can be seen that by deploying a transmission power level of 15 dBm, a link distance of 9,600 km can be achieved with a quality factor of 6.01 dB and BER (Bit error rate) of 1.07 × 10 − 9 $$1.07 \times {10^{- 9}}$$ . Also, in this paper, the performance of an 8×7 Gbps WDM-IsOWC link has been reported. The results show that by using both EDFA pre-amplifier and booster amplifier stages, a link distance of 8,000 km for each channel is achievable with desired performance levels (Q≥6 and BER≤ 10 − 9 $${10^{- 9}}$$ ). Also, the effect of channel spacing on the performance of WDM-IsOWC link is investigated. The results show that the received signal has acceptable performance levels when the channel spacing is 100 GHz but when the channel spacing is reduced to 80 GHz, the quality of the received signal degrades and link distance decreases.