Interhemispheric Differences Research Articles

Heschl's gyrus and the temporal pole: The cortical lateralization of language.

The left lateralization of language has been attributed to hemispheric specialization for processing rapidly changing information. While interhemispheric differences in auditory cortex organization support this view, the macrostructure of the entire cerebral cortex has not been thoroughly examined from this perspective. This study investigated hemispheric asymmetries in cortical surface area and thickness and their relationship to pronunciation scores from oral reading using the Human Connectome Project Young Adult dataset (N=1113). Heschl's gyrus had the most left-lateralized surface area, while the temporal pole showed the strongest right-lateralization in thickness. These areas correspond to the core components of speech: sound and meaning. Notably, their structural features were the only ones also yielding a significant correlation with pronunciation scores. Additionally, Broca's area's posterior region (pars opercularis), involved in articulatory phonological processing, showed leftward lateralization, contrasting with the right-lateralized anterior portions. Left-hemisphere language areas were largely thinner and more extended than their right-sided homologs with a larger white-to-gray matter ratio. Cortical thickness was inversely related to surface area. The lateralization of auditory-related language areas and their structure's correlation with pronunciation in oral reading supports a genetically based auditory foundation for language. A thinner, more efficient cortex with larger surface areas and increased myelination likely underlies the left-hemispheric dominance of language. Thinner, more extended brain areas have been linked to more myelination and wider cortical columns and intercolumnar space. This provides the potential for a fast network of interconnected, discrete information units able to support language's demands of rapid categorical processing.

Abstract 4140169: Neonatal Electroencephalogram Alpha:Delta changes precede neurologic injury during Antegrade Cerebral Perfusion and Deep Hypothermic Circulatory Arrest

Background: Although neurologic injury commonly occurs following neonatal aortic arch reconstruction, the mechanism(s) are poorly understood. A decrease or inter-hemispheric difference in the electroencephalogram (EEG) Alpha:Delta ratio (A:D) precedes cerebral ischemia during antegrade cerebral perfusion (ACP). However, it is unknown if A:D changes precede neurologic injury during deep hypothermic circulatory arrest (DHCA). We hypothesized during DHCA, the A:D would decrease and that a significant A:D inter-hemispheric difference would precede neurologic injury. Methods: Neonates requiring aortic arch reconstruction underwent simultaneous quantitative EEG monitoring. Left vs. right hemispheric, anterior, and posterior A:Ds were recorded at baseline, arterial cannulation, cooling, ACP vs. DHCA, and the rewarming phases of the operation. Left vs. right A:D differences > 25% were considered significant for ischemia and the cumulative duration of a significant A:D inter-hemispheric difference was calculated. Post-operative neurologic injury was defined as either stroke or seizure. Results: From 86 neonates, 16.2 % (14) required DHCA and 83.8 % (72) ACP. There were no significant differences in the pre-operative demographics or baseline A:Ds between groups. Although the A:Ds remained similar during ACP, after 15 minutes the hemispheric A:Ds decreased significantly during DHCA (Figure 1). Eleven neonates (ACP-7 vs. DHCA-4) developed neurologic injury. The duration of an anterior A:D inter-hemispheric difference > 25% was significantly greater within neonates that developed neurologic injury (25 {IQR:0,65 minutes} vs. 5 {IQR: 0, 15 minutes}; p<0.001). Multivariate analysis demonstrated that the duration of an anterior A:D difference > 25% was independently associated with neurologic injury using either ACP or DHCA (Odds Ratio:1.081, 95% CI: 1.025, 1.141; p-value=0.004). Conclusion: Unlike ACP, the A:D decreased significantly during DHCA. During either DHCA or ACP, a significant anterior inter-hemispheric A:D difference was independently associated with neurologic injury and suggests the importance of quantifying the A:D during neonatal arch reconstruction.

Asymmetry of the Frontal Aslant Tract and Development of Supplementary Motor Area Syndrome

Background/Objectives: The purpose of this study was to investigate preoperative interhemispheric differences of the FAT in relation to the onset of postoperative SMA syndrome. Methods: This was a single-center retrospective analysis of patients who underwent surgical resection of diffuse gliomas involving the SMA between 2018 and 2022. Inclusion criteria were availability of preoperative and postoperative Magnetic Resonance Imaging, no previous surgery, and no neurological deficits at presentation. Diffusion-weighted data were processed by spherical deconvolution (SD) and diffusion tensor imaging tractography algorithms, and TrackVis was used to dissect the FAT of both hemispheres. The FAT data were analyzed for correlation with postoperative SMA syndrome onset. Results: N = 25 cases were included in the study, among which n = 23 had preoperative bilaterally identifiable FAT by SD. N = 12 developed an SMA syndrome, 6 demonstrated a motor-only syndrome, 4 had a verbal-only syndrome, and 2 had mixed verbal and motor features. The SMA syndrome incidence was significantly more frequent in lower-grade gliomas (p = 0.005). On the tumor side, the FAT identified by SD was smaller than the contralateral (mean volume 6.53 cm3 and 13.33 cm3, respectively, p < 0.001). In the 6 cases that developed a verbal SMA syndrome, a normalized FAT volume asymmetry (FAT-VA) demonstrated an asymmetry shifted towards the non-dominant side (mean FAT-VA = −0.68), while the cases with no postoperative verbal impairment had opposite asymmetry towards the dominant side (mean FAT-VA = 0.42, p = 0.010). Conclusions: Preoperative interhemispheric FAT volume asymmetry estimated according to functional dominance can predict postoperative onset of verbal SMA syndrome, with proportionally smaller FAT on the affected dominant hemisphere.

The relationship between white matter architecture and language lateralisation in the healthy brain.

Interhemispheric anatomical differences have long been thought to be related to language lateralisation. Previous studies have explored whether asymmetries in the diffusion characteristics of white matter language tracts are consistent with language lateralisation. These studies, typically with smaller cohorts, yielded mixed results. This study investigated whether connectomic analysis of quantitative anisotropy (QA) and shape features of white matter tracts across the whole brain are associated with language lateralisation. We analysed 1040 healthy individuals (562 females) from the Human Connectome Project database. Hemispheric language dominance for each participant was quantified using a laterality quotient (LQ) derived from fMRI activation in regions of interest (ROIs) associated with a language comprehension task compared against a math task. A linear regression model was used to examine the relationship between structural asymmetry and functional lateralisation. Connectometry revealed a significant negative correlation between LQs and QA of corpus callosum tracts, indicating that higher QA in these regions is associated with bilateral and right-hemisphere language representation in frontal and temporal regions, respectively. Left language laterality in temporal lobe was significantly associated with longer right inferior fronto-occipital fasciculus (IFOF) and forceps minor tracts. These results suggest that diffusion measures of microstructural architecture as well as geometrical features of reconstructed white matter tracts play a role in language lateralisation. People with increased dependence on right or both frontal hemispheres for language processing may have more developed commissural fibres, which may support more efficient interhemispheric communication.Significance statement The left cerebral hemisphere is dominant for language functions in most people. In some healthy people, language functions are lateralised to the right hemisphere or distributed across both hemispheres. The anatomy underlying patterns of hemispheric language dominance are not well established. Emerging evidence suggests that white matter connectivity and architecture is an important feature of cortical functional organisation. In this work, we report that people who have language functions distributed across both hemispheres have greater inter-hemispheric connectivity compared to lateralised people. Our findings provide further insights into the anatomical basis of language function and may have wider clinical implications.

The role of MRI biomarkers in evaluation of symptomatic pineal cysts – a retrospective analysis

BackgroundOur aim was to determine whether the Apparent Diffusion Coefficient is able to predict the presence of a symptomatic pineal cyst by detecting cerebral edema.MethodsWe retrospectively analyzed MRIs of 45 patients with pineal cysts before and after resection and 51 patients without pineal cysts, comparing ADC values of thalamus, central, periventricular and subcortical white matter. Furthermore we evaluated cyst size and morphology and analyzed its correlation to ADC values in corresponding patients.ResultsDifferences between patients with symptomatic pineal cyst and control group were not significant (p = 0.200 – 0.968). ADC ratios did not change significantly after resection of the cyst (p = 0.575 – 0.862). Cyst size showed no significant correlation to ADC ratios (p = 0.071 – 0.918). Raw data analyses revealed more significance, especially periventricularly and in central white matter, which resulted in significant interhemispheric differences in ADC ratios in both subgroups (p < 0.001 and p = 0.031). MRI of 1.5T showed consistently higher values than 3T but mostly insignificant.ConclusionOur analysis revealed no evidence that pineal cysts lead to intracerebral edema caused by venous compression. Since variability was higher than the differences seen, ADC sequences do not appear to be an appropriate diagnostic tool for symptomatic pineal cysts.

Thalamic Nuclei Morphometry and Handedness: Assessing Grey Matter Volume Differences in Left- and Right-Dominant Individuals

The connection between thalamic structure and handedness has important implications for understanding the neural basis of lateralization, and this may shed light on the underlying mechanisms of motor control and cognitive processes. This study investigated the relationship between thalamic nuclei morphometry and handedness, aiming to elucidate the neuroanatomical basis of manual preference. Utilising neuroimaging data from a test-retest functional magnetic resonance imaging (MRI) dataset, T1-weighted volumes were acquired and processed using automated segmentation methods. Thalamic nuclei were parcellated into 25 regions, and grey matter volumes were analysed using the Freesurfer software tool. Statistical comparisons of the interhemispheric volume of the four thalamic nuclei between left- and right-dominant individuals were conducted using independent sample t-tests. This study identified interhemispheric differences in specific thalamic nuclei (the ventral anterior thalamic nucleus and the ventral posterolateral thalamic nuclei) in the left- and right-dominant individuals, suggesting structural variability within the thalamus associated with handedness. The findings underscore the importance of considering subcortical structures in understanding the neural basis of manual preference and highlight avenues for further research in thalamic morphology and its relationship with handedness.

Interhemispheric inhibition and gait adaptation associations in people with multiple sclerosis.

Multiple sclerosis is a neurodegenerative disease that damages the myelin sheath within the central nervous system. Axonal demyelination, particularly in the corpus callosum, impacts communication between the brain's hemispheres in persons with multiple sclerosis (PwMS). Changes in interhemispheric communication may impair gait coordination which is modulated by communication across the corpus callosum to excite and inhibit specific muscle groups. To further evaluate the functional role of interhemispheric communication in gait and mobility, this study assessed the ipsilateral silent period (iSP), an indirect marker of interhemispheric inhibition and how it relates to gait adaptation in PwMS. Using transcranial magnetic stimulation (TMS), we assessed interhemispheric inhibition differences between the more affected and less affected hemisphere in the primary motor cortices in 29 PwMS. In addition, these same PwMS underwent a split-belt treadmill walking paradigm, with the faster paced belt moving under their more affected limb. Step length asymmetry (SLA) was the primary outcome measure used to assess gait adaptability during split-belt treadmill walking. We hypothesized that PwMS would exhibit differences in iSP inhibitory metrics between the more affected and less affected hemispheres and that increased interhemispheric inhibition would be associated with greater gait adaptability in PwMS. No statistically significant differences in interhemispheric inhibition or conduction time were found between the more affected and less affected hemisphere. Furthermore, SLA aftereffect was negatively correlated with both average percent depth of silent period (dSP%AVE) (r = -0.40, p = 0.07) and max percent depth of silent period (dSP%MAX) r = -0.40, p = 0.07), indicating that reduced interhemispheric inhibition was associated with greater gait adaptability in PwMS. The lack of differences between the more affected and less affected hemisphere indicates that PwMS have similar interhemispheric inhibitory capacity irrespective of the more affected hemisphere. Additionally, we identified a moderate correlation between reduced interhemispheric inhibition and greater gait adaptability. These findings may indicate that interhemispheric inhibition may in part influence responsiveness to motor adaptation paradigms and the need for further research evaluating the neural mechanisms underlying the relationship between interhemispheric inhibition and motor adaptability.

Changes in the visual areas of the cerebral cortex in children with left-sided anisometropic amblyopia according to structural MRI and resting-state fMRI

Thanks to the development of structural and functional magnetic resonance imaging (MRI) methods, in recent decades there has been a lot of research aimed at elucidating brain abnormalities caused by amblyopia. In the cases of this prevalent visual disorder, the anomalies causing decreased visual acuity and other visual disabilities cannot be determined by standard ophthalmologic examination. Since there are several types of this disorder that are fundamentally different in etiology, it is natural to suggest the presence of different types of corresponding brain abnormalities. In this regard, before obtaining a general picture of the pathogenesis of amblyopia, studies conducted on groups of specially selected similar patients are very important. This paper presents the results of a study of school-age children with left-sided anisometropic amblyopia. In the patients investigated, MRI data revealed interhemispheric differences in the thickness of the lateral occipital cortex, and resting-state fMRI revealed interhemispheric differences in the local coherence of the hemodynamic signal within 17 Brodmann area and in the functional connectivity between 17 and 18+19 Brodmann areas. The data obtained contribute to the creation of a general MRI database on the pathophysiology of amblyopia, help clarify some controversial issues and indicate the advisability of using resting-state fMRI in ophthalmology.

Validation of Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS) chlorodifluoromethane (HCFC-22) in the upper troposphere and lower stratosphere

Abstract. The Atmospheric Chemistry Experiment Fourier Transform Spectrometer (ACE-FTS) is currently providing the only measurements of vertically resolved chlorodifluoromethane (HCFC-22) from space. This study assesses the ACE-FTS HCFC-22 v5.2 product in the upper troposphere and lower stratosphere, as well as simulations of HCFC-22 from a 39-year specified dynamics run of the Canadian Middle Atmosphere Model (CMAM39) in the same region. In general, ACE-FTS HCFC-22 observations tend to agree with subsampled CMAM39 data to within ±5 %, except for between ∼ 15 and 25 km in the extratropical regions where ACE-FTS exhibits a negative bias of 5 %–30 % and near 6 km in the tropics where ACE-FTS exhibits a bias of −15 %. When comparing against correlative satellite, aircraft, and balloon data, ACE-FTS typically exhibits a low bias on the order of 0 %–10 % between ∼ 5 and 15 km and is within ±15 % between ∼ 15 and 25 km. ACE-FTS, CMAM39, and surface flask measurements from the NOAA Global Monitoring Laboratory's surface air-sampling network all exhibit consistent tropospheric HCFC-22 trends ranging between 6.8 and 7.8 ppt yr−1 (within 95 % confidence) for 2004–2012 and between 3.1 and 4.7 ppt yr−1 (within 95 % confidence) for 2012–2018. Interhemispheric differences (IHDs) of HCFC-22 were also derived using ACE-FTS, NOAA, and CMAM39 data, and all three yielded consistent and correlated (r≥0.42) IHD time series, with the results indicating that surface IHD values decreased at a rate of 2.2 ± 1.1 ppt per decade between 2004 and 2018.

Interhemispheric differences of electroencephalography signal characteristics in different sleep stages

ObjectiveThe current electroencephalography (EEG) measurement setup is complex, laborious to set up, and uncomfortable for patients. We hypothesize that differences in EEG signal characteristics for sleep staging between the left and right hemispheres are negligible; therefore, there is potential to simplify the current measurement setup. We aimed to investigate the technical hemispheric differences in EEG signal characteristics along with electrooculography (EOG) signals during different sleep stages. MethodsType II portable polysomnography (PSG) recordings of 50 patients were studied. Amplitudes and power spectral densities (PSDs) of the EEG and EOG signals were compared between the left (C3-M2, F3-M2, O1-M2, and E1-M2) and the right (C4-M1, F4-M1, O2-M1, and E2-M2) hemispheres. Regression analysis was performed to investigate the potential influence of sleep stages on the hemispheric differences in PSDs. Wilcoxon signed-rank tests were also employed to calculate the effect size of hemispheres across different frequency bands and sleep stages. ResultsThe results showed statistically significant differences in signal characteristics between hemispheres, but the absolute differences were minor. The median hemispheric differences in amplitudes were smaller than 3 μv with large interquartile ranges during all sleep stages. The absolute and relative PSD characteristics were highly similar between hemispheres in different sleep stages. Additionally, there were negligible differences in the effect size between hemispheres across all sleep stages. ConclusionsTechnical signal differences between hemispheres were minor across all sleep stages, indicating that both hemispheres contain similar information needed for sleep staging. A reduced measurement setup could be suitable for sleep staging without the loss of relevant information.

Measurements and Modeling of the Interhemispheric Differences of Atmospheric Chlorinated Very Short‐Lived Substances

AbstractChlorinated very short‐lived substances (Cl‐VSLS) are ubiquitous in the troposphere and can contribute to the stratospheric chlorine budget. In this study, we present measurements of atmospheric dichloromethane (CH2Cl2), tetrachloroethene (C2Cl4), chloroform (CHCl3), and 1,2‐dichloroethane (1,2‐DCA) obtained during the National Aeronautics and Space Administration (NASA) Atmospheric Tomography (ATom) global‐scale aircraft mission (2016–2018), and use the Community Earth System Model (CESM) updated with recent chlorine chemistry to further investigate their global tropospheric distribution. The measured global average Cl‐VSLS mixing ratios, from 0.2 to 13 km altitude, were 46.6 ppt (CH2Cl2), 9.6 ppt (CHCl3), 7.8 ppt (1,2‐DCA), and 0.84 ppt (C2Cl4) measured by the NSF NCAR Trace Organic Analyzer (TOGA) during ATom. Both measurements and model show distinct hemispheric gradients with the mean measured Northern to Southern Hemisphere (NH/SH) ratio of 2 or greater for all four Cl‐VSLS. In addition, the TOGA profiles over the NH mid‐latitudes showed general enhancements in the Pacific basin compared to the Atlantic basin, with up to ∼18 ppt difference for CH2Cl2 in the mid troposphere. We tagged regional source emissions of CH2Cl2 and C2Cl4 in the model and found that Asian emissions dominate the global distributions of these species both at the surface (950 hPa) and at high altitudes (150 hPa). Overall, our results confirm relatively high mixing ratios of Cl‐VSLS in the UTLS region and show that the CESM model does a reasonable job of simulating their global abundance but we also note the uncertainties with Cl‐VSLS emissions and active chlorine sources in the model. These findings will be used to validate future emission inventories and to investigate the fast convective transport of Cl‐VSLS to the UTLS region and their impact on stratospheric ozone.

Atmospheric Δ14C in the northern and southern hemispheres over the past two millennia: Role of production rate, southern hemisphere westerly winds and ocean circulation changes

The variations of atmospheric Δ14C over the past two millennia are classically attributed to changes in its production rate in the upper atmosphere, which in turn is related to changes in solar activity and the Earth's magnetic field. However, the potential contribution of atmospheric and oceanic circulation changes during this period has not been precisely quantified. This has been achieved here using a coupled climate model simulating explicitly the evolution of the different carbon isotopes, driven by a new estimate of 14C production derived from 10Be measurements, and using different production rates for each hemisphere. Our results confirm that changes in global and hemispheric atmospheric Δ14C are primarily driven by changes in production rate. The very good agreement between our results and observed atmospheric Δ14C also highlights the strong consistency of current interpretations of 10Be and 14C measurements. By contrast, the interhemispheric difference in atmospheric Δ14C is controlled by changes in the intensity of southern hemisphere westerly winds (SHWW) that impact atmosphere-ocean exchange and the upwelling of 14C depleted water masses in the Southern Ocean. Changes in deep water formation in both hemispheres or open ocean polynyas in the Southern Ocean only have a small impact on atmospheric Δ14C over that period. When driven by changes in the SHWW proportional to three existing reconstructions of the Southern Annular Mode (SAM) index, the model reproduces some key characteristics of the observed interhemispheric Δ14C gradient. These include the low values in the 15th century and the peak in the 16th century, but there are also clear differences between the experiments and Δ14C observations. This suggests that while SAM reconstructions capture some robust features in the centennial variability, large uncertainties remain.

An investigation of the relationship between tropical monsoon precipitation changes and stratospheric sulfate aerosol optical depth

Abstract Stratospheric aerosol geoengineering (SAG) is one of the several solar geoengineering options that have been proposed to counteract climate change. In the case of SAG, reflective aerosols injected into the stratosphere would reflect more sunlight and cool the planet. When assessing the potential efficacy and risks of SAG, the sensitivity of tropical monsoon precipitation changes should be also considered. Using a climate model, we perform several stylized simulations with different meridional distributions and amounts of volcanic sulfate aerosols in the stratosphere. Because tropical monsoon precipitation responds to global mean and interhemispheric difference in radiative forcing or temperature, we quantify the sensitivity of tropical monsoon precipitation to SAG in terms of two parameters: global mean aerosol optical depth (GMAOD) and interhemispheric AOD difference (IHAODD). For instance, we find that the simulated northern hemisphere monsoon precipitation has a sensitivity of −1.33 ± 0.95% per 0.1 increase in GMAOD and −7.62 ± 0.27% per 0.1 increase in IHAODD. Our estimated precipitation changes in terms of the two sensitivity parameters for the global mean precipitation and for the indices of tropical, northern hemisphere, southern hemisphere and Indian summer monsoon precipitation are in good agreement with the model simulated precipitation changes. Similar sensitivity estimates are also made for unit changes in global mean and interhemispheric differences in effective radiative forcing and surface temperature. Our study based on planetary energetics provides a simpler framework for understanding the tropical monsoon precipitation response to external forcing agents.

Decoding Single-Pellet Retrieval Task From Local Field Potentials in Pre- and Post-Stroke Motor Areas: Insights Into Interhemispheric Connectivity Difference

Decoding Single-Pellet Retrieval Task From Local Field Potentials in Pre- and Post-Stroke Motor Areas: Insights Into Interhemispheric Connectivity Difference

Interhemispheric and longitudinal differences in the ionosphere–thermosphere coupling process during the May 2024 superstorm

Interhemispheric and longitudinal differences in the ionosphere–thermosphere coupling process during the May 2024 superstorm

Magnetic resonance imaging techniques for indirect assessment of myelin content in the brain using standard T1w and T2w MRI sequences and postprocessing analysis.

Magnetic Resonance Imaging (MRI) has revolutionized our ability to non-invasively study the brain's structural and functional properties. However, detecting myelin, a crucial component of white matter, remains challenging due to its indirect visibility on conventional MRI scans. Myelin plays a vital role in neural signal transmission and is associated with various neurological conditions. Understanding myelin distribution and content is crucial for insights into brain development, aging, and neurological disorders. Although specialized MRI sequences can estimate myelin content, these are time-consuming. Also, many patients sent to specialized neurological centers have an MRI of the brain already scanned. In this study, we focused on techniques utilizing standard MRI T1-weighted (T1w) and T2 weighted (T2w) sequences commonly used in brain imaging protocols. We evaluated the applicability of the T1w/T2w ratio in assessing myelin content by comparing it to quantitative T1 mapping (qT1). Our study included 1 healthy adult control and 7 neurologic patients (comprising both pediatric and adult populations) with epilepsy originating from focal epileptogenic lesions visible on MRI structural scans. Following image acquisition on a 3T Siemens Vida scanner, datasets were co registered, and segmented into anatomical regions using the Fastsurfer toolbox, and T1w/T2w ratio maps were calculated in Matlab software. We further assessed interhemispheric differences in volumes of individual structures, their signal intensity, and the correlation of the T1w/T2w ratio to qT1. Our data demonstrate that in situations where a dedicated myelin-sensing sequence such as qT1 is not available, the T1w/T2w ratio provides significantly better information than T1w alone. By providing indirect information about myelin content, this technique offers a valuable tool for understanding the neurobiology of myelin-related conditions using basic brain scans.

The Hemispheric Difference in Electric Potential and Electron Precipitation Observed by DMSP in the Auroral Zone

AbstractIn this case study, we focus on how hemispheric differences in the electric potential distribution in the auroral zones are related to hemispheric differences in the energetic particle precipitation that indicate the presence of field‐aligned potential drops. Utilizing data during the spring and fall equinox in 2013 and 2014 from the Defense Meteorological Satellite Program (DMSP) F16 and F17 satellites, we systematically examine simultaneous measurements of plasma drift velocity and particle precipitation in magnetically conjugate regions across the auroral zone in both hemispheres. This allows us to establish the degree to which the interhemispheric differences in ionospheric electric potential may be accounted for by field‐aligned potential drops. Thirty‐seven eligible cases examined show accelerated electron energy spectra at conjugate locations in the northern and/or southern hemispheres. Of these 37 cases, 23 show conjugate differences in electric potential that agree qualitatively with the observed electron acceleration and average energy of precipitating electrons in each hemisphere. This result suggests that the hemispheric differences in ionospheric electric potential in the auroral zone may be most frequently accounted for by field‐aligned potential drops along the magnetic flux tubes connecting conjugate points to the equatorial plane. The spatial and temporal variability of the potential distribution, electron precipitation, and magnetic field configuration could account for deviations from the normally observed situation in the remaining cases. More magnetically conjugate observations at various altitudes in both hemispheres are needed to investigate this hemispheric coupling in more detail.

MODERN METHODS FOR ASSESSING MOTOR AND SENSORY INTER-HEMISPHERIC ASYMMETRY OF THE BRAIN IN CHILDREN OF PRIMARY AND SECONDARY SCHOOL AGE (8-11 YEARS OLD)

Background: The neuropsychological study of some features of interhemispheric relationships in the motorsphere in children with various types of mental disorders is of undoubted interest. It can show a number of new aspects of the problem of the formation of inter-hemispheric asymmetry and inter-hemispheric interaction in ontogenesis. Methodology: Nowadays, two approaches are used in physiology to assess brain inter-hemispheric differences: the method of determining the "handiness" by means of a survey (Edinburgh test) and the method of actively detecting motor and sensory asymmetry by N.N. Bragina and T.A. Dobrokhotova methodology. Results: The neuropsychological study of some features of interhemispheric relationships in the motor sphere in children with various types of mental disorders is of undoubted interest. It can show a number of new aspects of the problem of the formation of inter-hemispheric asymmetry and inter-hemispheric interaction in ontogenesis. Both techniques are widely represented in modern scientific literature, but we have not found research that describes the relationship between the results of testing assessment of functional brain asymmetry using the Edinburgh test and tests for determining motor and sensory asymmetry. Normally, the formation of brain inter-hemispheric asymmetry and inter-hemispheric interaction is, of course, heterochronical in nature. Conclusion: Therefore, the examined schoolchildren may encounter an almost fully formed primary level of interhemispheric connections, while the second and third levels are still in their formation. At the same time, a comparison between the results of healthy children of 8–11 years of age shows that the functional organization of inter-hemispheric asymmetry and inter-hemispheric interaction in this age range is in a state of constant ongoing development.

Characterization of dynamic patterns of human fetal to neonatal brain asymmetry with deformation-based morphometry.

Despite established knowledge on the morphological and functional asymmetries in the human brain, the understanding of how brain asymmetry patterns change during late fetal to neonatal life remains incomplete. The goal of this study was to characterize the dynamic patterns of inter-hemispheric brain asymmetry over this critically important developmental stage using longitudinally acquired MRI scans. Super-resolution reconstructed T2-weighted MRI of 20 neurotypically developing participants were used, and for each participant fetal and neonatal MRI was acquired. To quantify brain morphological changes, deformation-based morphometry (DBM) on the longitudinal MRI scans was utilized. Two registration frameworks were evaluated and used in our study: (A) fetal to neonatal image registration and (B) registration through a mid-time template. Developmental changes of cerebral asymmetry were characterized as (A) the inter-hemispheric differences of the Jacobian determinant (JD) of fetal to neonatal morphometry change and the (B) time-dependent change of the JD capturing left-right differences at fetal or neonatal time points. Left-right and fetal-neonatal differences were statistically tested using multivariate linear models, corrected for participants' age and sex and using threshold-free cluster enhancement. Fetal to neonatal morphometry changes demonstrated asymmetry in the temporal pole, and left-right asymmetry differences between fetal and neonatal timepoints revealed temporal changes in the temporal pole, likely to go from right dominant in fetal to a bilateral morphology in neonatal timepoint. Furthermore, the analysis revealed right-dominant subcortical gray matter in neonates and three clusters of increased JD values in the left hemisphere from fetal to neonatal timepoints. While these findings provide evidence that morphological asymmetry gradually emerges during development, discrepancies between registration frameworks require careful considerations when using DBM for longitudinal data of early brain development.

Regional and interhemispheric differences of neuronal representations in dentate gyrus and CA3 inferred from expression of zif268

The hippocampal formation is one of the best studied brain regions for spatial and mnemonic representations. These representations have been reported to differ in their properties for individual hippocampal subregions. One approach that allows the detection of neuronal representations is immediate early gene imaging, which relies on the visualization of genomic responses of activated neuronal populations, so called engrams. This method permits the within-animal comparison of neuronal representations across different subregions. In this work, we have used compartmental analysis of temporal activity by fluorescence in-situ hybridisation (catFISH) of the immediate early gene zif268/erg1 to compare neuronal representations between subdivisions of the dentate gyrus and CA3 upon exploration of different contexts. Our findings give an account of subregion-specific ensemble sizes. We confirm previous results regarding disambiguation abilities in dentate gyrus and CA3 but in addition report novel findings: Although ensemble sizes in the lower blade of the dentate gyrus are significantly smaller than in the upper blade both blades are responsive to environmental change. Beyond this, we show significant differences in the representation of familiar and novel environments along the longitudinal axis of dorsal CA3 and most interestingly between CA3 regions of both hemispheres.