To explore the effect of programmed sedation and analgesia combined with nursing intervention on weaning and extubation of patients with tracheal intubation. 128 patients who underwent tracheal intubation in our hospital from January 2020 to March 2021 were randomly divided into two groups. The control group received routine intensive care intervention, used and adjusted analgesic and sedative drugs according to the doctor’s instructions. The intervention group was evaluated and monitored for programmed sedation and analgesia based on the control group. The mechanical ventilation, with tube and intensive care unit hospitalization time, delirium, unplanned extubation, ventilator-associated pneumonia and deep vein thrombosis were compared between the two groups. The incidence of adverse events, nursing satisfaction and the dosage of analgesic and sedative drugs were evaluated. The mechanical ventilation, with tube and intensive care unit hospitalization time were significantly shorter in intervention group (p<0.05). The incidence of adverse events such as delirium, unplanned extubation, ventilator-associated pneumonia and deep vein thrombosis in the intervention group was significantly lower than that in the control group (p<0.05), nursing satisfaction has also increased significantly. Program analgesia and sedation combined care for intensive care unit patients with tracheal intubation can improve the clinical efficacy, shorten the time of weaning extubation and intensive care unit stay, reduce the amount of sedatives, reduce the incidence of related adverse reactions and improve nursing satisfaction.