ACP Journal Club16 September 2008Intensive glucose control did not prevent important complications in type 2 diabetesVictor M. Montori, MD, MSc, German Malaga, MDVictor M. Montori, MD, MScMayo Clinic,, Rochester, Minnesota, USA (V.M.M.)Search for more papers by this author, German Malaga, MDUniversidad Peruana Cayetano Heredia, Lima, Peru (G.M.)Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-149-6-200809160-02006 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Source CitationThe ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;358:2560-72. https://pubmed.ncbi.nlm.nih.gov/18539916Clinical Impact RatingsEndocrinology: Nephrology: References1 Stratton IM, Adler AI, Neil HA, et al. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective observational study. BMJ. 2000;321:405-12. [PMID: 10938048] Google Scholar2 Montori VM, Permanyer-Miralda G, Ferreira-González I, et al. Validity of composite end points in clinical trials. BMJ. 2005;330:594-6. [PMID: 15761002] Google Scholar3 Montori VM, Devereaux PJ, Adhikari NK, et al. Randomized trials stopped early for benefit: a systematic review. JAMA. 2005;294:2203-9. [PMID: 16264162] Google Scholar4 Singh S, Loke YK, Furberg CD. Long-term risk of cardiovascular events with rosiglitazone: a meta-analysis. JAMA. 2007;298:1189-95. [PMID: 17848653] Google Scholar5 Shichiri M, Kishikawa H, Ohkubo Y, Wake N. Long-term results of the Kumamoto Study on optimal diabetes control in type 2 diabetic patients. Diabetes Care. 2000;Supp 2:B21-9. [PMID: 10860187] Google Scholar6 Gaede P, Lund-Andersen H, Parving HH, Pedersen O. Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med. 2008;358:580-91. [PMID: 18256393] Google Scholar Author, Article, and Disclosure InformationAffiliations: Mayo Clinic,, Rochester, Minnesota, USA (V.M.M.)Universidad Peruana Cayetano Heredia, Lima, Peru (G.M.)This article was published at Annals.org on 2 September 2008. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoIntensive glucose control increased mortality and did not prevent cardiovascular events in type 2 diabetes Victor M. Montori and German Malaga Metrics Cited byEffect of glycemic control on markers of subclinical atherosclerosis in patients with type 2 diabetes mellitus: A review 16 September 2008Volume 149, Issue 6Page: JC3-6KeywordsDrug regulationDrugsGlucoseHbA1cHypoglycemiaMortalityMyocardial infarctionRetinopathyType 2 diabetesVascular diseases ePublished: 16 September 2008 Issue Published: 16 September 2008 Copyright & PermissionsCopyright © 2008 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...