Through a combination of latest scientific research and technological innovations, the United States (US) beef industry has made some tremendous achievements in beef feedlot production through improved genetics, nutrition and pharmaceutical research among others. This is beneficial in that the country can be able to produce enough food to meet the demands of the nation and also get income through export. Advances in animal nutrition and pharmaceutical research have too resulted not only to fast growth rates but better carcass quality which is beneficial to the producer. However, some of these developments are still faced with a number of challenges such as costs and scarcity of resources such as land given the increasing human population. Developments in breeding for example use of sexed semen has not only shown the advantage on sex but has proved to reduce the incidences of dystocia especially where a producer use X bearing sperm to have only female calves. However, the cost for semen still remains a big challenge in large cattle herds thus not always producer friendly. A long lasting sustainable production is therefore necessary.