ABSTRACT This dissertation utilizes primarily optical observations of extended emission-line regions in active and cooling-flow galaxies to clarify the nature of this nebulosity and its underlying sources of energy. In particular, I employ case studies of Seyfert galaxies in order to elucidate nuclear properties as seen in light that is apparently scattered into our line of sight, and to provide direct measurements of emission-line intensity ratios resulting from a radially diluted, photoionizing continuum for comparison with theory. The apparent Seyfert 2 galaxy NGC 4388 displays a weak, spatially extended, broad-line emission that is most readily understood as scattered light from a hidden Seyfert 1 nucleus. IC 5135 exhibits both Seyfert 2 and starburst activity in its nucleus, and the influence of both can be traced in nuclear emission-line profiles as well as line-intensity ratios of spatially resolved nebulosity. I also report results bearing on star formation and the rate of mass accretion in the cluster cooloing-flow galaxy NGC 1275, as revealed from spectroscopy of the nebular filaments in this system. While preferential low-mass star formation has been invoked to reconcile high X-ray inferred accretion rates in cooling flows with a paucity of apparent cooled matter, data reported here reveal a site of high-mass star formation in material believed to arise from the flow. Detailed scrutiny of this region suggests, moreover, that the initial mass function of star formation in this locale is unlikely to be biased unusually toward low-mass star formation. These results provide additional evidence that the true rate of mass deposition may be less than implied by a simple interpretation of the X-ray data. The same data set is used to derive improved upper temperatures. The ability of these measurements to constrain the accretion rate is limited by exclusion of the galaxy center, which is host to a Seyfert nucleus. Finally, I present results of a narrow-band imaging survey of X-ray selected, early-type galaxies that are examined for evidence linking nebulosity in these sources to cooling-flow or weak Seyfert phenomena. These results suggest that optical nebulosity in these systems probably bears a multiparameter relationship to cooling flows, active nuclei, and accretion from external sources.