Amplification Of Intensity Research Articles

Ultrafast upconversion superfluorescence with a sub-2.5 ns lifetime at room temperature

Photon upconversion through lanthanide-doped nanoparticles is of great significance for various applications. However, the current development of upconversion nanoparticles is hindered by the low quantum efficiency and long radiative lifetimes of lanthanide ions, restricting their applications in time-dependent nanophotonics. Herein, we report ultrafast upconversion superfluorescence with a lifetime of sub-2.5 ns in lanthanide-doped nanoparticles at room temperature. Upon excitation with an 800-nm fs-pulsed laser, we achieve a large number (N = 912) of correlated dipoles in Nd3+-concentrated nanoparticles, resulting in collective coherent emission with two orders of magnitude amplification in intensity and more than three orders of magnitude improvement in the radiative decay rate. Furthermore, we demonstrate that the control of excitation power and emitting sample length enables the lifetime manipulation of upconversion emission in a wide range from μs to sub-ns, accompanied by the typical superfluorescence signature of Burnham-Chiao ringing. These findings may benefit applications in many advanced technologies such as quantum counting and high-speed super-resolution bioimaging.

Activatable red/near-infrared aqueous organic phosphorescence probes for improved time-resolved bioimaging

Abstract Organic red/near-infrared (NIR) room-temperature phosphorescence (RTP) holds significant potential for autofluorescence-free bioimaging and biosensing due to its prolonged persistent luminescence and exceptional penetrability. However, achieving activatable red/NIR organic RTP probes with tunable emission in aqueous solution remains a formidable challenge. Here we report on aqueous organic RTP probes with red/NIR phosphorescence intensity and lifetime amplification. These probes consist of supramolecular assemblies comprising macrocyclic cucurbit[8]uril and amine-containing alkyl-bridged pyridiniums, exhibiting viscosity-activatable phosphorescence with enhanced quantum yield (up to 20%) and lifetime. Notably, by utilizing this activatable organic RTP probe, we successfully achieve two-photon imaging of lysosomal viscosity and millisecond scale time-resolved cell imaging. Moreover, intravital phosphorescence imaging using RTP probe enable the monitoring of viscosity variations in inflammatory mice, demonstrating a significantly improved signal-to-background ratio compared to fluorescence imaging. This activatable red/NIR supramolecular platform facilitates versatile high-resolution phosphorescence imaging for in vivo tracking of specific biomarkers and physiological events.

A quantitative explanation for the large impacts of El Niño during its decaying stage

Abstract This study examines the comparative atmospheric circulation and tropical sea surface temperature (SST) relationships during the developing and decaying stages of El Niño from a meridional structure standpoint. Results indicate a transition in the variability of the first two modes of the Hadley Circulation (HC) during these stages, with the first mode exhibiting a larger explained variance in the decaying stage. The regime change in HC variability corresponds to underlying anomalous SST distributions, as confirmed by sensitive experiments. Quantitative assessment reveals the HC-SST response amplitudes are approximately two times stronger during the decaying stage compared to the developing stage. Employing the Kuo-Eliassen (KE) equation, diabatic heating anomalies during the decaying stage explain the difference in air-sea response intensity between the two stages. Diabatic heating variations are identified as the primary contributor to amplification or reduction of air-sea response intensity during the respective El Niño stages, providing insights into the different air-sea processes throughout the El Niño lifespan.

Exploring novel circulating biomarkers for liver cancer through extracellular vesicle characterization with infrared spectroscopy and plasmonics

BackgroundHepatocellular carcinoma (HCC) is the most common form of liver cancer, with cirrhosis being a major risk factor. Traditional blood markers like alpha-fetoprotein (AFP) demonstrate limited efficacy in distinguishing between HCC and cirrhosis, underscoring the need for more effective diagnostic methodologies. In this context, extracellular vesicles (EVs) have emerged as promising candidates; however, their practical diagnostic application is restricted by the current lack of label-free methods to accurately profile their molecular content. To address this gap, our study explores the potential of mid-infrared (mid-IR) spectroscopy, both alone and in combination with plasmonic nanostructures, to detect and characterize circulating EVs. ResultsEVs were extracted from HCC and cirrhotic patients. Mid-IR spectroscopy in the Attenuated Total Reflection (ATR) mode was utilized to identify potential signatures for patient classification, highlighting significant changes in the Amide I-II region (1475-1700 cm−1). This signature demonstrated diagnostic performance comparable to AFP and surpassed it when the two markers were combined. Further investigations utilized a plasmonic metasurface suitable for ultrasensitive spectroscopy within this spectral range. This device consists of two sets of parallel rod-shaped gold nanoantennas (NAs); the longer NAs produced an intense near-field amplification in the Amide I-II bands, while the shorter NAs were utilized to provide a sharp reflectivity edge at 1800–2200 cm−1 for EV mass-sensing. A clinically relevant subpopulation of EVs was targeted by conjugating NAs with an antibody specific to Epithelial Cell Adhesion Molecule (EpCAM). This methodology enabled the detection of variations in the quantity of EpCAM-presenting EVs and revealed changes in the Amide I-II lineshape. SignificanceThe presented results can positively impact the development of novel laboratory methods for the label-free characterization of EVs, based on the combination between mid-IR spectroscopy and plasmonics. Additionally, data obtained by using HCC and cirrhotic subjects as a model system, suggest that this approach could be adapted for monitoring these conditions.

Antibiotic-Fe3O4 nanoparticles with highly efficient catalytic activity for enhanced chemiluminescence detection of tetracyclines residues in foods

Tetracyclines (TCs) are the most commonly antimicrobial agents that used in livestock production worldwide. It is important to supervise tetracyclines residues in food for environmental monitoring and food safety. In this study, a novel, label-free chemiluminescence (CL) assay without antibody was established. Fe3O4 NPs could facilitate the CL interaction between luminol and H2O2. Interestingly, TCs could enhance the catalytic ability of Fe3O4 NPs and result in a further amplification of the CL intensity. The CL intensity varied linearly with the concentration of tetracycline (TC), oxytetracycline (OTC), chlortetracycline (CTC), and ranging from 10–2400, 10–2800, and 5–2100 nmol/L, respectively; The limits of detection were 4 nmol/L for TC, 6 nmol/L for OTC, and 2 nmol/L for CTC. This CL strategy was applied successfully in testing three TCs residues in milk, eggs and honey samples with more sensitive results, which provided an alternative strategy for monitoring the correct use of TCs.

Improvement on electrochemiluminescence properties of graphite carbon nitride by metal oxidation state regulation

AbstractReasonable design is of great significance for improving the performance of electrochemiluminescence (ECL) co‐reactant accelerators. The different d‐band structure of metal single atoms will produce different oxidation states, which may change the adsorption of reaction intermediates to the catalyst and affect its catalytic activity. In this study, we have demonstrated that the ECL performances of graphite carbon nitride (CN) can be promoted by modulating the metal oxidation states of co‐reaction accelerator for the first time. The oxidation states of Au were modulated by the different electronic metal–support interaction (EMSI) between the co‐reaction accelerator (Au single atoms, Au nanoparticles [Au NPs]) and CN, and the effects of Au oxidation states on the ECL performances of CN were investigated. Comparison to pristine CN and CN nanosheets supported Au nanoparticles (Au NPs/CN), stronger and more stable ECL intensity of CN nanosheets supported Au single‐atoms (AuS/CN) was obtained. The ECL signal of AuS/CN was about 32.2 times that of the original CN, and 2.8 times that of Au NPs/CN in the same Au loading content (0.8%). Detailed mechanism revealed that AuS/CN with higher Au oxidation state has better conductivity and stronger catalytic activity, which promotes the electric reduction of CN and S2O82−, increases the lifetime of the excited state CN*, and significantly improves the ECL performance of CN. In addition, this work provides a detailed understanding of the essence of EMSI for the ECL intensity amplification and established a feasible method for the improvement of ECL capacities of co‐reactant accelerators.

Drivers of Magnetic Field Amplification at Oblique Shocks: In Situ Observations

Collisionless shocks are ubiquitous structures throughout the Universe. Shock waves in space and astrophysical plasmas convert the energy of a fast-flowing plasma to other forms of energy, including thermal and magnetic energies. Plasma turbulence and high-amplitude electric and magnetic fluctuations are necessary for effective energy conversion and particle acceleration. We survey and characterize in situ observations of reflected ions and magnetic field amplification rates at quasiperpendicular shocks under a wide range of upstream conditions. We report magnetic amplification rates as high as 25 in our current data set. Reflected ions interacting with the incoming plasma create magnetic perturbations that cause magnetic amplification in upstream and downstream regions of quasiperpendicular shocks. Our observations show that, in general, magnetic amplification increases with the fraction of reflected ions, which itself increases with Mach number. Both parameters plateau once full reflection is reached. Magnetic amplification continuously increases with the inverse of the magnetization parameter of the upstream plasma. We find that the extended foot region upstream of shocks and nonlinear processes within that region are key factors for intense magnetic amplification. Our observations at nonrelativistic shocks provide the first experimental evidence that below a certain magnetization threshold, the magnetic amplification efficiency at quasiperpendicular shocks becomes comparable to that at the quasiparallel shocks.

Large eddy simulation of aerodynamic wind pressure on a tall rectangular building by modified synthetic volume forcing method

To accurately predict wind pressures on a tall building by numerical Computational Fluid Dynamics (CFD) using the Large-Eddy Simulation (LES) turbulent model, it is essential to generate inflow with realistic turbulence characteristics. The Discretizing and Synthesizing Random Flow Generation (DSRFG) method, as one of the synthetic Fourier methods, has received significant attention in the Computational Wind Engineering (CWE) community because of its ability to strictly satisfy the continuity condition and generate turbulent wind with the desired power spectra. In traditional LES, the desired turbulent wind is normally generated and specified at the inlet. However, this treatment often leads to significant attenuation in turbulence energy in the high-frequency band of the fluctuating wind speed spectrum along the flow direction and unrealistic large-amplitude wind pressure fluctuations, resulting in unsatisfactory prediction performance. The Synthetic Volume Forcing (SVF) method effectively overcomes these limitations by introducing turbulence as volume force into the moment Navier-Stokes (N-S) equations. In this study, the DSRFG method is applied to generate a fluctuating wind field in combination with the SVF method to simulate dynamic wind pressures on a tall rectangular building through open-source software OpenFOAM. The turbulence intensity amplification factor (TIAF) is introduced in the SVF method to further improve its simulation accuracy. Comparison of results with wind tunnel test results verifies that the proposed TIAF-SVF numerical method developed in this study achieved sufficient accuracy in predicting wind pressures on tall buildings.

Enhancing the optical properties of organic fluorine compound-encapsulated AlGaN-based ultraviolet light-emitting diodes with Ni/Au reflective electrodes

The development of AlGaN-based high-efficiency UVC-LEDs capable of effectively eliminating viruses and bacteria is desired. In this study, we demonstrate a significant improvement in optical output power (LOP) by applying optical interference technology and organic fluorine compound packaging technology. Experiments and calculations revealed that an improvement in LED die LOP was achieved through adjusting the optical length to approximately 0.7·λ n, resulting in an amplification of light intensity caused by the interference of light emitted perpendicular to the die. Furthermore, by coating the LED die with an organic fluorine compound and packaging it in a quartz lens, the LOP increased by a factor of 1.5. Ray-tracing analysis showed that, due to optical interference, the LOP of the LED die was more dependent on the light output from the top surface than from the side.

A sensing platform for highly sensitive immunoassay based on metal-enhanced fluorescence of CdSe@ZnS

Insufficient sensitivity caused by low radiative intensity of employed fluorescent material is the main obstacle toward early accurate diagnosis of fatal diseases when applying fluorescence analysis. Herein, we have developed a dual amplification procedure to overcome this issue. We first synthesize high-quality CdSe@ZnS@SiO2 core/shell quantum dots (QDs) with type-I band alignment to confine the carrier wave functions, thus ensuring high quantum yield (∼ 80%). The fluorescence intensity of those QDs is further amplified by localized surface plasmon resonance effect enabled by gold nanoparticles. We finally construct CdSe@ZnS@SiO2 and Au@SiO2 immune sandwich biosensor platform, and take C-reaction protein (CRP) as a test case. It is shown that this biosensor platform exhibits a wide detecting range between 0.5 and 100 ng/mL, and detecting limit of 0.076 ng/mL. We further apply this detecting scheme in serum and actual clinical, competing performance compared with the prevailing standard measurements in hospital has been obtained. Both experiment and the finite element analysis (FEA) approach calculation results indicate that a highly enhanced electric field between Au@SiO2 and CdSe@ZnS@SiO2 enhances the radiative recombination rates of the QDs@SiO2 and decreases the fluorescence lifetime of that. The fluorescence intensity amplification scheme proposed herein is of great significance for the real-time and high-sensitivity early detection of biomarkers in the biomedicine.

Realism of Tactile Texture Playback: A Combination of Stretch and Vibration.

This study investigates the effects of two stimulation modalities (stretch and vibration) on natural touch sensation on the volar forearm. The skin-textile interaction was implemented by scanning three textures across the left forearm. The resulting skin displacements were recorded by the digital image correlation technique to capture the information imparted by the textures. The texture recordings were used to create three playback modes (stretch, vibration, and both), which were reproduced on the right forearm. Two psychophysical experiments compared the texture scans to rendered texture playbacks. The first experiment used a matching task and found that to maximize perceptual realism, i.e., similarity to a physical reference, subjects preferred the rendered texture to have a playback intensity of 1X - 2X higher on DC components (stretch), and 1X - 3.5X higher on AC components (vibration), varying across textures. The second experiment elicited similarity ratings between the texture scans and playbacks and showed that a combination of stretch and vibration was required to create differentiated texture sensations. However, the intensity amplification and use of two stimuli were still insufficient to create fully realistic texture sensations. We conclude that mechanisms beyond single-site uniaxial stimuli are needed to reproduce realistic textural sensations.

Development of benzaldehyde-pyrazoline hybrids for functionalization of polymers with fluorescent pendant moieties.

Compounds with a pyrazoline scaffold are useful as sensors for fluorescence detection of different types of analytes. Recovery of a pyrazoline-based sensor with a view to use it recurrently would be more facile when the sensing molecule is attached to a solid support. A reaction sequence has been designed to synthesize two benzaldehyde-pyrazoline hybrids as examples of a hitherto unknown type of compounds to be employed for the potential derivatization of polymers containing primary amino groups through azomethine formation. All intermediates, including the fairly unstable N1 -unsubstituted pyrazolines, along with the target compounds have been structurally characterized, with an emphasis on their particular NMR features. Examination of the photophysical properties of these benzaldehyde-pyrazoline hybrids showed that, despite the shortening of the extended N1-N2-C3 conjugated system common to 1,3,5-triarylpyrazolines through the replacement of the aryl at N1 by an aryloxyacetyl moiety, the novel compounds exhibit emission maxima at approximately 350 nm. Moreover, the introduction of a moderately electron-withdrawing substituent such as chlorine in the phenyl at C3 of pyrazoline leads to an amplification of fluorescence intensity.

A novel fluorescent aptasensor for the detection of theophylline based on cryonase-driven signal amplification strategy.

In the study, we have developed an expedient and efficient method for the detection of theophylline based on the amplification of the signal intensity of fluorescence based on oxidized single-walled carbon nanohorns (oxSWCNHs)/cryonase. When theophylline was not present in the system, oxSWCNHs can adequately adsorb nucleic acid probes labeled by carboxyfluorescein (FAM). In the presence of theophylline, the nucleic acid probe forms the tertiary probe-theophylline complex, which detaches from the surface of the oxSWCNHs. Then, upon reaction with cryonase, the complex can release the FAM and theophylline into the next cycle. The fluorescence signal of the system exhibits a 1:N magnification, enabling quantitative detection of theophylline. The linear range was 30-150 ng/mL, and the limit of detection (LOD) was 6.04 ng/mL. At the same time, it can also be used to detect theophylline in mouse serum.

Shock interactions and heating predictions on a V-shaped blunt leading edge at Mach 6–12

V-shaped blunt leading edges (VSBLEs) are usually found at the inlet lips of air-breathing hypersonic vehicles and irregular shape flows. In this work, the VSBLE flows are investigated using numerical simulations and theoretical analysis from Mach 6 to Mach 12. The simulation results show that complex shock–shock interactions around the VSBLE cause extremely high heat flux peaks, which nonlinearly increase with the freestream Mach numbers. To theoretically study the flow mechanism, the shock interactions are divided into large-scale primary shock interactions (PSIs) and micro-scale secondary shock interactions (SSIs). The PSIs are constant, but the SSIs experience a transition from Mach reflection to regular reflection with the Mach number increasing. A transition criterion for the SSIs is established by the shock interaction theory. Furthermore, the increase in the heat flux peaks is proved to be caused by the SSI transition. A semi-empirical heat flux prediction method that relates the shock intensity and heat flux amplification is established. Finally, the transition criterion and the heat flux prediction method are verified by simulations at higher Mach numbers and experiments of VSBLEs with different geometric parameters. This paper develops a theoretical analysis approach for quickly predicting the shock interaction types and heat flux peaks of the VSBLEs under a wide range of Mach numbers.

Aiming for Maximized and Reproducible Enhancements in the Obstacle Race of SERS.

Surface enhanced Raman scattering (SERS), since its discovery in the mid-1970s, has taken on many roles in the world of analytical measurement science. From identifying known and unknown chemicals in mixtures such as pharmaceutical and environmental samples to enabling qualitative and quantitative analysis of biomolecules and biomedical disease markers (or biomarkers), furthermore expanding to tracking nanostructures in vivo for medical diagnosis and therapy. This is because SERS combines the inherent power of Raman scattering capable of molecular species identification, topped with tremendous amplification in the Raman signal intensity when the molecule of interest is positioned near plasmonic nanostructures. The higher the SERS signal amplification, the lower the limit of detection (LOD) that could be achieved for the above applications. Therefore, improving SERS sensing efficiencies is vital. The signal reproducibility and SERS enhancement factor (EF) heavily rely on plasmonic nanostructure design, which has led to tremendous work in the field. But SERS signal and EF reproducibility remain key limitations for its wider market usability. This Review will scrutinize factors, some recognized and some often overlooked, that dictate the SERS signal and are of utmost importance to enable reproducible SERS EFs. Most of the factors pertain to colloidal labeled SERS. Some critically reviewed factors include the nanostructure's surface area as a limiting factor, SERS hot-spots including optimizing the SERS EF within the hot-spot volume and positioning labels, properties of label molecules governing molecule orientation in hot-spots, and resonance effects. A better understanding of these factors will enable improved optimization and control of the experimental SERS, enabling extremely sensitive LODs without overestimating the SERS EFs. These are crucial steps toward identification and reproducible quantification in SERS sensing.

Solid State Phosphorescence Enhancement of PtII-Based Emitters via Combination of π-Hole(Isocyano Group)⋅⋅⋅ dz2[PtII] and I···Cl Halogen-Bonding Interactions

The PtII isocyanide complex [Pt(ppy)Cl(CNC6H4-C≡C-Ph)] (1, Hppy=2-phenylpyridine) was co-crystallized with 1,4-diiodotetrafluorobenzene (1,4-DITFB), yielding 1·½(1,4-DITFB) adduct. The I···Cl halogen-bonding and π-π-stacking interactions combined with the rare π-hole(isocyano group)⋅⋅⋅dz2[PtII] interactions were identified via analysis of X-ray diffraction data of the co-crystals. These two types of structure-determining interactions supplemented each other, and the system of I⋯Cl and π-hole(isocyano group)⋅⋅⋅dz2[PtII] contacts achieved a 1D extended ladder-type architecture. The density functional theory calculations, employing a set of computational tools, verified the role of I⋯Cl and π-hole(isocyano group)⋅⋅⋅dz2[PtII] noncovalent bonds in the spectrum of noncovalent forces. The solid-state photophysical study revealed an amplification of luminescence intensity in the co-crystals, which is attributed to the suppression of the nonradiative relaxation pathways due to an increase in the rigidity of the chromophore center.

Nocebo effects in visceral pain: concept and design of the experimental randomized-controlled pain study 'NoVis'.

The role of psychological factors in the pathophysiology and treatment of chronic visceral pain in disorders of gut-brain interactions (DGBI) is increasingly appreciated. Placebo research has underscored that expectations arising from the psychosocial treatment context and from prior experiences shape treatment responses. However, effects of negative expectations, i.e., nocebo effects, as they are likely crucial elements of DGBI patients' clinical reality, have thus far only rarely been investigated in the context of visceral pain, with untapped potential for improved prevention and treatment. The experimental randomized-controlled pain study "NoVis," carried out within the Collaborative Research Center (CRC) 289 ("Treatment Expectation"), aims to close gaps regarding the generation and persistence of nocebo effects in healthy volunteers. It is designed to elucidate effects of negative expectations in a multiple-threat paradigm with intensity-matched rectal distensions and cutaneous thermal stimuli, allowing to test nocebo effects in the visceral and somatic pain modalities. Negative expectations are experimentally induced by elements of doctor-patient communication (i.e., instruction) and/or by surreptitious amplification of symptom intensity (i.e., experience/learning) within a treatment context. Accordingly, the repeated measures between-subject design contains the between-group factors "treatment instruction" (negative vs. control) and "treatment experience" (negative vs. control), with volunteers randomized into four experimental groups undergoing several pain stimulation phases (repeated factor). This allows to compare the efficacy of instruction vs. experience, and more importantly, their combined effects on the magnitude of negative expectations and their impact on pain responses, which we expect will be greatest for the visceral modality. After a Baseline, short-term effects are assessed during a test phase accomplished on study day 1 (Test-1 Phase). To explore the persistence of effects, a second test phase is accomplished 1 week later (Test-2 Phase). Effects of negative expectations within and across pain modalities are assessed at the subjective and objective levels, with a focus on psychophysiological and neuroendocrine measures related to stress, fear, and anxiety. Since nocebo effects can play a considerable role in the generation, maintenance, or worsening of chronic visceral pain, and may even constitute risk factors for treatment failure, knowledge from experimental nocebo research has potential to improve treatment outcomes in DGBI and other clinical conditions associated with chronic visceral pain.

P05.03.B METHYLOME PROFILING OF GLIOBLASTOMAS WITH FGFR3/TACC3 FUSION

Abstract BACKGROUND Glioblastomas (GBMs) with the FGFR3-TACC3 (F3T3) gene fusion have histological, molecular, metabolic, and clinicoradiological characteristics. They have a better prognosis compared to other GBMs. Recent findings suggest that methylome profiling could further stratify these patients identifying a subgroup (defined as “outlier” F3T3+ GBMs, or GBM-F3T3-O) with a methylation profile resembling gangliogliomas (GGs), low-grade histological appearance, and a better outcome. MATERIAL AND METHODS We performed DNA methylation profiling (Infinium MethylationEPIC Array v1.0) of 32 adult diffuse gliomas with FGFR3 gene fusions (30 FGFR3-TACC3, one FGFR3-ACLY, and one FGFR3-MYO18A), plus two paired samples of a diffuse glioma with two distinct contingents (one with positive FGFR3 staining and FGFR3-TACC3 gene fusion, the other with intense EGFR staining and EGFR gene amplification). All cases corresponded to “glioblastoma, IDH-wildtype” according to the WHO CNS5. Methylation data were submitted to the DFKZ brain tumor classifier (molecularneuropathology.org), versions 11b4 and 12.5 and to dimensionality reduction with t-distributed stochastic neighbor embedding (tSNE). Copy-number variation (CNV) estimation based on conumee package was obtained from DFKZ website. RESULTS With the brain tumor classifier v11b4, most cases (26/34, 76%) were classified as methylation class (MC) GBM (17/26 with a significant score ≥0.9). Out of them, 23/26 (88%) were significantly (score ≥0.5) classified in the “GBM, mesenchymal” (16/26, 62%) or in the “GBM, RTK II” methylation families (7/26, 27%). With the classifier v12.5, again most tumors were classified as “GBM, mesenchymal” (18/34, 53%) or “GBM, RTK II” (9/34, 26%), of which twelve (12/34, 35%) with a score ≥0.9. Two were classifed as GG (score 0.69 and 0.39), both having “GBM, mesenchymal” as a second hit (score 0.19 and 0.33, respectively). Five had GG as a second hit, although with low scores (range <0.01-0.25). After tSNE dimensionality reduction of our and literature cases, most tumors clustered together with other GBM, mesenchymal and GBM, RTK II cases. Only two cases fell within a distinct cluster corresponding to GBM-F3T3-O tumors from the literature. These included two histologically defined GBMs with a survival of 26 and 100 months. Recurrent inferred CNV included chromosome (chr) 7 gain (96%) and chr10 loss (85%), followed by chr20 gain (46%), chr22q loss (46%), and chr19 gain (33%). The presence of chr19 gain (alone or associated with chr20 gain) was associated with increased survival (p=0.01). CONCLUSION Glioblastomas with FGFR3 fusions (mostly F3T3) have an epigenomic profile close to other mesenchymal and RTK II GBMs. Methylation analysis identifies methylation (GBM-F3T3-O) and CNV (chr19 gain) profiles associated with better survival.

Topological skin modes and intensity amplification in a nonlinear non-Hermitian lattice

Topological skin modes and intensity amplification in a nonlinear non-Hermitian lattice

Effect of Interplay between Parallel and Perpendicular Magnetic and Electric Fields on Partial Discharges

This paper reports on the influence of a magnetic field on the dynamics of partial discharges (PDs) in two distinct configurations with respect to the mutual orientation of electric fields. The broad application areas include electrical insulation systems of both high-voltage grids and industrial network devices as well as emerging segments such as electric vehicles or more electric aircraft. Traditionally, PD measurements are only carried out in an electric field. In all current-carrying power equipment, magnetic fields are also superimposed onto electric ones, thus influencing partial discharge behavior. It has been observed that the interplay between electric and magnetic fields influences the dynamics of PDs; parallel and perpendicular mutual orientations were specifically investigated. The measurement technique allowed us to quantitively detect the effect of magnetic fields on PDs in a corona point–plane arrangement. The novel element presented in this article is a detection of PD intensity modulated by a magnetic field, with both perpendicular and parallel orientations with respect to electric one, and a quantitative visualization in the form of the time-sequence diagrams. The simulation of electron trajectories in the presence of electric and magnetic fields revealed the elongation of the pathways and differentiation of the charged particle propagation times. The perpendicularly oriented magnetic field led to a twisting effect, whereas the parallel alignment reflected the propagation along a helical trajectory. A slightly stronger PD intensity amplification effect was observed in the case of a parallel alignment of electric versus magnetic fields as compared with the perpendicular orientation. The presented results may contribute to PD measurement methodology in both electric and magnetic fields as well as a better understanding of the underlying physical mechanisms. The observed effect of the modulation of the magnetically based PD dynamics may be relevant for the insulation systems of power equipment.