AbstractDespite the profound societal impacts of intense tropical cyclones (TCs), prediction of future changes in their regional occurrence remains challenging owing to climate model limitations and to the infrequent occurrence of such TCs. Here we reveal projected changes in the frequency of major TC occurrence (i.e., maximum sustained wind speed: ≥ 50 m s−1) on the regional scale. Two independent high-resolution climate models projected similar changes in major TC occurrence. Their spatial patterns highlight an increase in the Central Pacific and a reduction in occurrence in the Southern Hemisphere—likely attributable to anthropogenic climate change. Furthermore, this study suggests that major TCs can modify large-scale sea-level pressure fields, potentially leading to the abrupt onset of strong wind speeds even when the storm centers are thousands of kilometers away. This study highlights the amplified risk of storm-related hazards, specifically in the Central Pacific, even when major TCs are far from the populated regions.