Intensity Resistance Exercise Research Articles

Effect Of Low Intensity Resistance Exercise Training On Cognitive Function In Middle-aged And Older Individuals

Effect Of Low Intensity Resistance Exercise Training On Cognitive Function In Middle-aged And Older Individuals

ACUTE ANDROGEN AND GLUCOCORTICOID RECEPTOR RESPONSE FOLLOWING A MODERATE INTENSITY RESISTANCE EXERCISE BOUT

PURPOSE: The purpose of this study was to examine the acute androgen receptor (AR) and glucocorticoid receptor (GR) response to a moderate intensity resistance exercise bout in resistance trained (RT) and untrained men (UT). METHODS: RT men (n = 10; X ± SD, age = 21.3 ± 1.7 yrs, height = 175.8 ± 6.8 cm, body mass = 84.5 ± 13.5 kg, back squat 1RM = 154.3 ± 19.3 kg, training history = 5.4 ± 2.0 yrs) and UT men (n = 9; X ± SD, age = 20.8 ± 3.1 yrs, height = 178.7 ± 8.9 cm, body mass = 81.0 ± 14.0 kg, squat 1RM = 108.1 ± 13.7 kg, training history = 0.7 ± 1.7 yrs) volunteered for this study. Prior to the RE bout, subjects were strength tested for back squat (BS) and leg extension (LE). Subjects returned 4-7 days later between 10am-2pm, and completed a RE bout consisting of 6 sets of 10 repetitions of BS at 75% 1RM, immediately followed by 4 sets of 10 repetitions of LE at 75% 1RM with 1.5 min rest between all sets. Muscle samples were collected from the vastus lateralis prior to exercise (PRE) and 10 min (10P), 30 min (30P), 60 min (60P), and 180 min (180P) post exercise. Total AR and GR expression was determined via western blotting. Receptor data were not normally distributed, thus all receptor data were analyzed using Mann-Whitney U test, Friedman test, and Wilcoxon signed-rank test. RESULTS: For total AR expression, there were no differences between time points within the RT group (p > .05); however, there were differences between time points within the UT group (p = .016). In the UT group, total AR expression significantly decreased at 30P (-19%∆, z = -2.192, p = .027) and 60P (-11%∆, z = -2.192, p = .027) post exercise, but returned to baseline values by 180P (z = -.178, p > .05). For Total GR content, there were no differences between time points within the RT or UT groups (p > .05). Total GR content was significantly greater in the RT group compared to the UT group at 10P (Mann-Whitney U = 19, z = -2.123, p = .035). CONCLUSIONS: While no changes were observed for AR expression in the RT group, the UT subjects experienced a significant decrease in AR expression at 30P and 60P suggesting acute AR responses vary depending on training status. No differences were seen across time for the GR in either group; however, RT and UT subjects were different from each other at 10P. It is unclear if these responses are related to the acute hormonal response; therefore, future research will address this.

The Influence Of Flotation Restricted Environmental Stimulation Therapy On Recovery From High Intensity Resistance Exercise

Flotation-restricted environmental stimulation therapy (flotation-REST) attenuates afferent nervous system signaling to promote relaxation of the body and mind. Despite limited research, the intervention has become increasingly popular among high performance populations (e.g., athletes, military) seeking to accelerate recovery and enhance performance readiness. PURPOSE: to determine whether flotation-REST augments recovery from high intensity resistance exercise known to induce significant metabolic, adrenergic and mechanical stress. METHODS: Eleven resistance trained males (age: 22.5± 2.3 years; height: 176.4±6.0 cm; weight: 85.7±6.2 kg; back squat 1RM: 153.1±20.1 kg; strength to weight ratio: 1.8±0.2) participated in a randomized, crossover-controlled research study. In one testing block high intensity resistance exercise (6 x 10 back squats at 80% 1RM, 2 min rest) was followed by a one-hour flotation-REST session, while recovery in the remaining block consisted of a sensory stimulating control. Markers of neuroendocrine signaling (catecholamines, cortisol, testosterone), structural damage (myoglobin, creatine kinase), inflammation (IL-6, TNF-alpha) and psychological perception (soreness, mood, fatigue) were measured before exercise (PRE), immediately post exercise (IP), post 1-hour recovery (1R), twenty-four hours post exercise (+24) and forty-eight hours post exercise (+48). Mean differences were assessed using repeated measures ANOVA with pairwise post-hoc comparisons (p ≤ .05). Effect sizes (ES) were calculated to evaluate magnitude of significant treatment differences. RESULTS: Flotation-REST significantly decreased soreness across the 48-hour recovery period (ES, IR: 0.68, +24: 0.47, +48: 0.28). Immediate improvements in positive affect (ES, IR: 0.74), negative affect (ES, IR: 1.03) and fatigue (ES, 1R: 1.13) were accompanied by differences in neuroendocrine signaling. Norepinephrine was significantly reduced (ES, 1R: 0.99) and testosterone significantly increased (ES, 1R: 0.32) in flotation-REST compared to control. No treatment differences were displayed for structural damage or inflammation. CONCLUSION: The data suggest a positive impact of flotation-REST in the first 48 hours of recovery, particularly where psychological appraisal is involved.

The Effects Of Foam Rolling On Exercise Induced Muscle Damage

Exercise-induced muscle damage (EIMD) occurs following strenuous and unaccustomed exercise. EIMD is associated with elevated creatine kinase (CK) blood concentrations, limitations in range of motion (ROM), and cellular swelling. EIMD may negatively affect training quality and performance thus methods to mitigate EIMD may be useful to resistance training populations. Self-myofascial release, in particular foam rolling (FR), has been utilized by competitive and recreational athletes to ameliorate the effects of EIMD. However, the effect of FR on EIMD has yet to be established. PURPOSE: The purpose of this study is to investigate the effect of FR on markers of EIMD after an acute bout of high volume resistance exercise. METHODS: Eight participants (five males and three females), between the ages of 18 and 35, completed two acute resistance exercise bouts (10 sets of 10 repetitions barbell back squat at 60% 1RM) separated by a minimum of seven days. Following one exercise bout, subjects performed FR targeting the thigh (i.e hamstrings and quadriceps), the shank (i.e. calf and tibialis anterior), and the gluteus maximus immediately post, 24, and 48 hours post exercise, while no FR was performed following the alternate bout (CON). In both conditions, participants were asked to refrain from additional recovery methods following exercise. Outcome measures included serum CK, hip ROM, knee ROM, and thigh circumference. All measurements were pre-exercise, immediately post, 24, and 48 hours post. RESULTS: There was a significant increase in serum CK from pre to 24 hours post (p = 0.04), as well as 24 and 48 hours post (p = 0.04). Hip ROM (p = 0.02) and knee ROM (p = 0.03) decreased and thigh circumference (p = 0.03) increased 48 hours post exercise. No significant differences between FR and CON were found for any measures. CONCLUSION: FR does not attenuate markers of muscle damage (i.e. serum CK, hip ROM, knee ROM, and thigh circumference) after an acute bout of high volume resistance training. This study suggests that despite its common practice, FR may not be an effective strategy for mitigating EIMD.

High Intensity Resistance Exercise Training vs. High Intensity (Endurance) Interval Training to Fight Cardiometabolic Risk Factors in Overweight Men 30-50 Years Old.

Cardiovascular and cardiometabolic diseases are leading causes of death worldwide. Exercise favorably affects this problem, however only few invest (enough) time to favorably influence cardiometabolic risk-factors and cardiac morphology/performance. Time-effective, high-intensity, low-volume exercise protocols might increase people's commitment to exercise. To date, most research has focused on high-intensity interval training (HIIT), the endurance type of HIT, while corresponding HIT-resistance training protocols (HIT-RT) are rarely evaluated. In this study we compared the effect of HIIT vs. HIT-RT, predominately on cardiometabolic and cardiac parameters in untrained, overweight-obese, middle-aged men. Eligible, untrained men aged 30–50 years old in full-time employment were extracted from two joint exercise studies that randomly assigned participants to a HIIT, HIT-RT or corresponding control group. HIIT predominately consisted of interval training 90 s−12 min, (2–4 sessions/week), HIT-RT (2–3 sessions/week) was applied as a single set resistance training to muscular failure. Core intervention length of both protocols was 16 weeks. Main inclusion criteria were overweight-obese status (BMI 25–35 kg/m2) and full employment (occupational working time: ≥38.5 h/week). Primary study-endpoint was the Metabolic Syndrome (MetS) Z-Score, secondary study-endpoints were ventricular stroke volume index (SVI) and myocardial mass index (MMI) as determined by Magnetic Resonance Imaging. The Intention to treat (ITT) principle was applied to analyze the summarized data set. Twenty-seven eligible men of the HIT-RT and 30 men of the HIIT group were included in the ITT. Both interventions significantly (p < 0.001) improve the MetS Z-Score, however the effect of HIIT was superior (p = 0.049). In parallel, HIT-RT and HIIT significantly affect SVI and MMI, with the effect of HIIT being much more pronounced (p < 0.001). Although HIIT endurance exercise was superior in favorably affecting cardiometabolic risk and particularly cardiac performance, both exercise methods positively affect cardiometabolic risk factors in this overweight to obese, middle-aged cohort of males with low time resources. Thus, the main practical application of our finding might be that in general overweight-obese people can freely choose their preferred exercise type (HIIT-END or HIT-RT) to improve their cardiometabolic health, while investing an amount of time that should be feasible for everybody.Trial Registrations: NCT01406730, NCT01766791.

Resistance Exercise and Knee Osteoarthritis

Resistance Exercise and Knee Osteoarthritis

Randomized clinical trial on the effect of a supervised exercise program on quality of life, fatigue, and fitness following esophageal cancer treatment (PERFECT study).

12055 Background: Patients with potentially curable esophageal cancer are often treated with chemoradiotherapy followed by surgery. This treatment might have a negative impact on physical fitness, fatigue and quality of life (QoL). In patients with other types of cancer, evidence suggests that physical exercise reduces treatment related side effects. We investigated whether a supervised exercise program also beneficially affects QoL, fatigue and cardiorespiratory fitness (CRF) in patients after treatment for esophageal cancer. Methods: The multicenter PERFECT study randomly assigned patients in the first year after esophagectomy to an exercise intervention (EX) or usual care (UC) group. EX patients participated in a 12-week moderate to high intensity aerobic and resistance exercise program supervised by a physiotherapist. UC patients were advised to maintain their physical activity levels. Attendance and compliance with the exercise intervention protocol were retrieved from exercise logs. QoL (primary outcome, EORTC-QLQ-30, range 0-100), fatigue (MFI-20, range 4-20) and CRF (cardiopulmonary exercise testing) were assessed at baseline and after 12 weeks (post-intervention). The outcomes were analyzed as between-group differences using either linear mixed effects models or ANCOVA adjusted for baseline and stratification factors (i.e. sex, time since surgery, center), according to the intention-to-treat principle. Results: A total of 120 patients (age 64±8) were included and randomized to EX (n = 61) or UC (n = 59). Patients in the EX group participated in 96% (IQR:92-100%) of the supervised exercise sessions and compliance with all parts of the exercise program was high ( &gt; 90%). Post-intervention, global QoL was not statistically different between groups, but significant (p &lt; 0.05) beneficial EX effects were found for QoL-Summary scores (between-group difference 3.5, 95% CI 0.2;6.8) and QoL-role functioning (9.4, 1.3;17.5). Physical fatigue wat non-significantly lower in the EX group (-1.2; -2.6;0.1, p = 0.08). CRF was significantly higher (VO2peak (1.8 mL/min/kg, 0.6;3.0) following the EX intervention. Conclusions: Patients were well capable to complete an intensive supervised exercise program after esophageal cancer treatment, which led to small but significant improvements in several aspects of QoL and cardiorespiratory fitness. Our results suggest that supervised exercise is a beneficial addition to routine care of patients with esophageal cancer. Clinical trial information: NTR5045 .

Moderate- to high intensity aerobic and resistance exercise reduces peripheral blood regulatory cell populations in older adults with rheumatoid arthritis

ObjectiveExercise can improve immune health and is beneficial for physical function in patients with rheumatoid arthritis (RA), but the immunological mechanisms are largely unknown. We evaluated the effect of moderate- to high intensity exercise with person-centred guidance on cells of the immune system, with focus on regulatory cell populations, in older adults with RA.MethodsOlder adults (≥65 years) with RA were randomized to either 20-weeks of moderate – to high intensity aerobic and resistance exercise (n = 24) or to an active control group performing home-based exercise of light intensity (n = 25). Aerobic capacity, muscle strength, DAS28 and CRP were evaluated. Blood samples were collected at baseline and after 20 weeks. The frequency of immune cells defined as adaptive regulatory populations, CD4 + Foxp3 + CD25 + CD127- T regulatory cells (Tregs) and CD19 + CD24hiCD38hi B regulatory cells (Bregs) as well as HLA-DR−/lowCD33 + CD11b + myeloid derived suppressor cells (MDSCs), were assessed using flow cytometry.ResultsAfter 20 weeks of moderate- to high intensity exercise, aerobic capacity and muscle strength were significantly improved but there were no significant changes in Disease Activity Score 28 (DAS28) or CRP. The frequency of Tregs and Bregs decreased significantly in the intervention group, but not in the active control group. The exercise intervention had no effect on MDSCs. The reduction in regulatory T cells in the intervention group was most pronounced in the female patients.ConclusionModerate- to high intensity exercise in older adults with RA led to a decreased proportion of Tregs and Bregs, but that was not associated with increased disease activity or increased inflammation.Trial registrationImproved Ability to Cope With Everyday Life Through a Person-centered Training Program in Elderly Patients With Rheumatoid Arthritis - PEP-walk Study, NCT02397798. Registered at ClinicalTrials.gov March 19, 2015.

Acute Psychological Effects of Resistance Exercise in Men With Symptoms of Muscle Dysmorphia: A Pilot Study.

SantaBarbara, NJ, Nosrat, S, Whitworth, JW, Ciccolo, JT. acute psychological effects of resistance exercise in men with symptoms of muscle dysmorphia: A pilot study. J Strength Cond Res 37(2): 277-283, 2023-This study tested the acute psychological effects of resistance exercise in men with symptoms of muscle dysmorphia. Twenty-one men completed 4 on-site sessions including a single session of moderate- (70% of 10 repetition maximum [RM]) and high- (100% of 10RM) intensity resistance exercise in a counter balanced order separated by at least 48 hours. State body image, perceived muscle size, exercise enjoyment, and ratings of perceived exertion (RPE) were assessed before, during, and after each session, and statistical significance was set a priori at p < 0.05. State body image significantly improve from pre to post during both sessions ( p < 0.01), with greater effect sizes seen for the high- ( d = 0.57) compared with the moderate- ( d = 0.39) intensity session. Perceived muscle size improved from pre to post during the high-intensity only ( p < 0.01, d = 0.66), and subjects enjoyed the high-intensity session significantly more than the moderate-intensity session ( p = 0.01), despite significantly higher RPE at each timepoint ( p < 0.01). Results contend with previous findings that show more positive psychological effects of moderate- compared with high-intensity resistance exercise. Education and client observation are essential to be aware of the potential for muscle dysmorphia. In instances where muscle dysmorphia is suspected, referral to qualified mental health professionals is recommended.

Whey Protein Supplementation is Associated with Antioxidant Markers Following Severe Eccentric Contractions in Obesity

Objective: Intense muscle contractions are associated with oxidative stress and immune system deficiency, especially in the presence of obesity. This study aimed to determine the effect of whey protein supplementation following eccentric resistance contractions on some determinants of oxidative stress in non-athletic obese students. Materials and Methods: In this double blinded randomized clinical trial study, 24 non-athlete obese male students were divided into two groups: experimental (whey protein supplementation, 0.4 g / kg body weight for 3 consecutive days) or placebo groups by simple random sampling. Blood samples were taken before, immediately, 24, 48 and 72 hours after an intense resistance exercise session with regard to measure Superoxidasedismutase(SOD) and Malodaldoeide (MDA). Subsequently, a two-way repeated measure ANOVA was performed to compare data between groups. P -value of less than 5 percent was considered statistically significant. Results: No significant differences were observed between two groups in MDA ( P -value: 0.211) and SOD ( P -value: 0.222) at postexercise. Based on ANOVA data, significant changes were observed between two groups with regard to MDA ( P -value: 0.001) and SOD ( P -value: 0.001). On the other hand, MDA activity was significantly lower in experimental than placebo subjects in each stage of study (24 hours recovery, 48 hours recovery and 72 hours recovery with P value: 0.001). Also, SOD activity was significantly higher in experimental than placebo subjects in each stage of study (24 hours recovery, 48 hours recovery and 72 hours recovery with P -value: 0.001). Conclusion: Based on this study, it is concluded that whey protein supplementation can be improve antioxidant capacity after intense exercise in non-athletes obese male.

Effect of a novel low volume, high intensity concurrent training regimen on recruit fitness and resilience

ObjectivesTo determine the effect of a novel low volume high intensity concurrent training regimen and warm-up on physiological performance and musculoskeletal injury in Australian recruits. DesignControlled longitudinal intervention. MethodsMilitary recruits completed 12 weeks of either experimental (EXP: n=78, 6-8RM resistance loads, and high intensity intervals) or basic military (CON: n=69, usual practice) matched for total sessions and time. Endurance (3.2km 22kg-load carriage, V˙O2 peak, multi-stage fitness test (MSFT)), 1RM strength and local muscle endurance (bench, squat, box-lift and push-ups) and power (squat jump) were assessed at Weeks 1,6,12. Body composition, physical activity (PAC·min−1) and heart rate reserve (HRR%), were assessed at Weeks 2,7,9. Musculoskeletal injury and mechanism were recorded. Two-way repeated measures ANOVA interaction (group×time), mean difference and effect size (ES) are reported p≤0.05. ResultsA significant interaction over 12 weeks was observed for load carriage (ES −0.30), squat jump (ES 0.65), V˙O2 peak (ES 0.58), MSFT (ES 0.41), push-ups (ES 0.26), 1RM bench (ES 0.26), squat (ES 1.05) and box lift (ES 0.27) in EXP compared to CON. At Week 12 significantly greater squat (38.9kg), MSFT (2.1mL·kg−1·min−1), and faster load carriage (49.9s) was observed in EXP than CON, but no difference in body composition. EXP had a lower PAC·min−1 (641.1±63.1) but higher HRR% (21.8±4.0) compared to CON. EXP had a lower number of injuries (6) compared to CON (17). ConclusionsThe inclusion of compound-specific resistance exercise and high intensity intervals improved physical function and was associated with reduced musculoskeletal injury.

Exercise Supervision Is Important for Cardiometabolic Health Improvements: A 16-Week Randomized Controlled Trial.

Hunter, JR, Gordon, BA, Bird, SR, and Benson, AC. Exercise supervision is important for cardiometabolic health improvements: a 16-week randomized controlled trial. J Strength Cond Res 34(3): 866-877, 2020-Exercise supervision enhances health and fitness improvements in clinical populations compared with unsupervised or home-based exercise, but effects of supervision type are unknown in healthy employees. Eighty-five Australian university employees (62 females; mean ± SD 43.2 ± 9.8 years) were randomized to personal (1:1; SUP, n = 28), nonpersonal (typical gym-based; NPS, n = 28) supervision or unsupervised control (CON, n = 29) exercise groups. Subjects received a 16-week individually tailored, moderate-to-high intensity aerobic and resistance exercise program completed at an onsite exercise facility (SUP and NPS) or without access to a specific exercise facility (CON). Repeated-measures ANOVA analyzed changes to cardiometabolic outcomes. Mean ± SD increases to V[Combining Dot Above]O2 peak were greater (p < 0.01) with SUP (+10.4 ± 11.1%) vs. CON (+3.8 ± 8.9%) but not different to NPS (+8.6 ± 8.2%). Compared to CON (+1.7 ± 7.7%), upper-body strength increases were greater with SUP (+12.8 ± 8.4%; p < 0.001) and NPS (+8.4 ± 7.3%; p < 0.05). Lower-body strength increases were greater with SUP (+26.3 ± 12.7%) vs. NPS (+15.0 ± 14.6%; p < 0.05) and CON (+4.1 ± 12.4%; p < 0.001), and NPS vs. CON (p < 0.01). Body fat reductions were greater with SUP (-2.2 ± 2.2%) vs. NPS (-0.6 ± 1.9%; p < 0.05) and CON (-0.7 ± 1.9%; p < 0.05). Access to an onsite exercise facility with personal or nonpersonal exercise supervision was important for improving several cardiometabolic outcomes, with greater improvements to lower-body strength and body composition from personal 1:1 exercise supervision.

The effect of blood flow restriction exercise on exercise-induced hypoalgesia and endogenous opioid and endocannabinoid mechanisms of pain modulation.

This study aimed to investigate and compare the magnitude of exercise-induced hypoalgesia (EIH) with low-intensity blood flow restriction (BFR) resistance exercise (RE) at varying pressures to other intensities of resistance exercise and examine endogenous mechanisms of pain reduction. Twelve individuals performed four experimental trials involving unilateral leg press exercise in a randomized crossover design: low-load RE at 30% of one repetition maximum (1RM), high-load RE (70% 1RM), and BFR-RE (30% 1RM) at a low and high pressure. BFR pressure was prescribed relative to limb occlusion pressure at 40% and 80% for the low- and high-pressure trials. Pressure pain thresholds (PPT) were assessed before and 5 min and 24 h following exercise in exercising and nonexercising muscles. Venous blood samples were collected at the same timepoints to determine plasma concentrations of beta-endorphin and 2-arachidonoylglycerol. High-pressure BFR-RE increased PPTs in the exercising limb to a greater extent than all other trials. Comparable systemic EIH effects were observed with HLRE and both BFR-RE trials. PPTs in the exercising limb remained elevated above baseline at 24 h postexercise following both BFR-RE trials. Postexercise plasma beta-endorphin concentration was elevated during the BFR-RE trials. No changes to 2-arachidonoylglycerol concentration were observed. High pressure BFR-RE causes a greater EIH response in the exercising limb that persists for up to 24 h following exercise. The reduction in pain sensitivity with BFR-RE is partly driven by endogenous opioid production of beta-endorphin. BFR-RE should be investigated as a possible pain-modulation tool in individuals with acute and chronic pain.NEW & NOTEWORTHY High-pressure blood flow restriction (BFR) causes a greater hypoalgesia response in the exercising limb (48%) compared with light and heavy load resistance exercise (10-34%). Performing light load resistance exercise with BFR causes systemic hypoalgesia comparable with heavy load resistance exercise (10-18%). BFR resistance exercise prolonged the exercise-induced hypoalgesia response for 24 h in the exercising limb (15% and 24%, respectively). Activation of endogenous opioid production and a conditioned pain modulation effect partly mediate the relationship between exercise and hypoalgesia.

Abstract P1-11-01: Effect of aerobic and resistance exercise on Reynolds risk score in overweight or obese breast cancer survivors

Abstract Background Breast cancer survivors have approximately double the risk of mortality from cardiovascular disease than age-matched women without a cancer history. Reynolds risk score is a validated algorithm for the assessment of cardiovascular disease, which incorporates high sensitivity C-Reactive Protein (hsCRP), hemoglobin A1c (HbA1c), and parental history of myocardial infarction with traditional biomarkers including cholesterol, systolic blood pressure (SBP), and presence of diabetes. We previously demonstrated that exercise improves Framingham risk score (12.0±2.0 to 2.0±1.5), calculated by traditional risk factors of cardiovascular disease, SBP (132.9±13.0 to 120.7±9.5 mmHg), high-density lipoprotein cholesterol (HDL-C; 43.1±6.6 to 64.7±7.8 mg/dL), and total cholesterol (TC; 196.5 ± 53.4 to 157.5 ± 37.1 mg/dL), in breast cancer survivors. This secondary analysis sought to examine the effects of a 16-week aerobic and resistance exercise intervention on Reynolds risk score in breast cancer survivors. Methods One hundred overweight or obese (BMI&amp;gt;25kg/m2) sedentary breast cancer survivors (stage I-III) who completed cancer treatment within 6 months prior to enrollment were randomized to the Exercise group (EX; n=50) or the Control (CON; n=50). The EX underwent supervised moderate-to-vigorous intensity aerobic and resistance exercise sessions 3 times/week for 16 weeks. The CON was asked to maintain their current level of activity. Reynolds risk score was calculated for each participant by assigning values for each of the following eight categories: age, SBP, TC, HDL-C, presence of diabetes; HbA1c, smoking status, hsCRP; and parental history of myocardial infarction. Within-group and between-group differences in mean change for individual outcomes measured at 16 weeks were evaluated using general linear models repeated-measures analyses of variance and mixed model repeated-measures analysis, respectively. Results Following the 16-week study period, Reynolds risk score was significantly reduced (8.3% to 0.9%), with improvements in hsCRP (3.4±0.6 to 2.3±0.3 mg/L), presence of diabetes (40 to 20%), and HbA1c (7.5±0.9 to 2.9±0.2%) in EX compared to CON (P&amp;lt;0.01). There were no significant changes in TC (194.4±48.9 to 210.4±52.2), HDL-C (41.0±4.3to 39.9±4.0), SBP (133.7±9.7to 135.9±9.8), hsCRP (3.7±0.3 to 4.2±0.4), presence of diabetes (22 to 24%), HbA1c (7.5±0.8 to 7.9±0.8) and Reynolds risk score in CON (P&amp;gt;0.05). Conclusion A 16-week supervised aerobic and resistance exercise intervention is an effective approach to reduce the risk of developing cardiovascular disease by reducing hsCRP, cholesterol, diabetes status, and SBP in breast cancer survivors. Participation in supervised exercise training during cancer survivorship should be considered to reduce the risk for cardiovascular disease mortality in breast cancer survivors. Citation Format: Kyuwan Lee, Debu Tripathy, Wendy Demark-Wahnefried, Kerry Courneya, Joanne Mortimer, Christina Dieli-Conwright. Effect of aerobic and resistance exercise on Reynolds risk score in overweight or obese breast cancer survivors [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P1-11-01.

Abstract P1-17-14: Physical activity platform to improve bone health in cancer survivors

Abstract Cancer treatment-induced bone loss and the subsequent risk of fractures in both men and women is a significant burden on national health care. The number of cancer survivors in the United States will reach 18 million by 2022 and by 2025, the projected burden of osteoporosis is $25.3 billion. Cancer patients treated with medications that lower hormone levels face an increased risk of fractures. Clinical studies report that moderate- intensity resistance exercises prevent a decline in bone health in female cancer survivors, and that strength training may reduce complications associated with cancer such as fatigue, muscle wasting, and bone loss. Unfortunately, only a small percentage of female cancer survivors engage in and adhere to a strength training exercise routine. Several factors account for this low level of engagement such as poor awareness of the benefits of exercise, lack of motivation, and the lack of affordable and easily accessible exercise programs designed for cancer survivors. Internet-based self-managed programs of exercises and guidance can potentially address these problems, and can be scaled for broader dissemination. The Thrivors™ internet-based platform seeks to shift the current paradigm of poor adherence to exercise by providing an affordable and accessible means of improving outcomes for cancer survivors. The product, Thrivors plus Bone Health (Thrivors+BH), will be a first-of-its-kind offering of clinically validated bone health exercises that can be customized to a cancer survivor's pain and energy levels, with several novel interactive feedback features. The product has supportive modules for connecting with a community of other users, mindfulness training, nutritional advice and a repository of educational information. The Thrivors™ platform is scalable, device-agnostic, and allows analysis of de-identified usage data. With commercialization potential for healthcare providers and health insurance payers, Thrivors™ provides a value-based care delivery model focused on outcomes. There are multiple important physiologic and psychosocial secondary conditions that could be positively impacted by the Thrivors™ platform. For this specific clinical trial, we focus on adherence to bone health exercises. Investigators: Cathy Skinner, MA - CEO and Founder, Thrivors (https://www.linkedin.com/in/cathyskinner/) Doug Yee, MD - Director of the Masonic Cancer Center, University of Minnesota (https://www.linkedin.com/in/douglas-yee-50402a14/) Kerri Winters-Stone, PhD - Professor, OHSU (https://www.linkedin.com/in/kerriwintersstone/) Kathryn Schmitz, PhD, MPH - Professor, Penn State - (https://www.linkedin.com/in/kathryn-schmitz-32a3891b/) Citation Format: Cathy Skinner. Physical activity platform to improve bone health in cancer survivors [abstract]. In: Proceedings of the 2019 San Antonio Breast Cancer Symposium; 2019 Dec 10-14; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2020;80(4 Suppl):Abstract nr P1-17-14.

Effect of Acute Bouts of Volume-Matched High-Intensity Resistance Training Protocols on Blood Glucose Levels.

Monroe, JC, Naugle, KM, and Naugle, KE. Effect of acute bouts of volume-matched high-intensity resistance training protocols on blood glucose levels. J Strength Cond Res 34(2): 445-450, 2020-Resistance exercise has the capability to alter glucose metabolism in healthy adults; however, to what extent single sessions of varying intensities of resistance exercise affect capillary glucose levels is not completely understood. The purpose of this study was to compare the effect of different resistance training intensities on capillary blood glucose levels in healthy adults. Thirteen resistance-trained men (age 24.4 ± 2.7 years) participated in an evaluation and 2 separate experimental resistance training sessions. The experimental sessions were a high-intensity resistance training session (HT) consisting of 7 sets of 3 repetitions at 90% of the participant's estimated 1 repetition maximum (e1RM), and a moderate-/high-intensity resistance training session (MT) consisting of 3 sets of 9 repetitions at 70% of the participant's e1RM. At least 7 days separated the completion of each session. Four glucose readings during each session were recorded using a capillary glucometer: G1 (baseline); G2 (pre-exercise); G3 (after exercise); and G4 (10 minutes after exercise). Results were analyzed using repeated-measures analysis of variances. Analysis revealed a significant decrease in blood glucose levels between G2 and G3, and G2 and G4 in both the HT and MT experimental sessions (p = 0.045). In addition, there was a significant difference in the magnitude of change in glucose levels from G2 to G3 between HT and MT (HT = -38.2 ± 5.3% SE, p = 0.042, MT = -22.2 ± 5.9% SE). Although both of the acute resistance exercise protocols decreased blood glucose levels in healthy men, a greater decrease in blood glucose levels from pre-exercise to post-exercise was observed in HT group compared with MT group.

Low Dose Resistance Exercise: A Pilot Study Examining Effects on Blood Pressure and Augmentation Index Between Intensities

The effects of resistance exercise on vascular function are unclear. To investigate the acute haemodynamic (blood pressure and augmentation index) and rate of perceived exertion (RPE) response to two types of resistance exercises of equal workload-a set of unilateral 35% of one repetition maximum (1RM) quadriceps extension and a set of unilateral 70% 1RM quadriceps extension. Twenty two young healthy males completed both exercises on separate days. Heart rate, central and peripheral systolic and diastolic blood pressure (BP), augmentation pressure, augmentation index (AIx), augmentation index at a heart rate of 75 beats per minute (AIx75), and RPE were measured using applanation tonometry before exercise, immediately after exercise, 5min after exercise and 15min after exercise. AIx75 was significantly lower 5min after exercising at 35% of 1RM than 70% of 1RM. Systolic blood pressure was significantly lower at 5min post exercise for both intensities. There was no significant difference in RPE between conditions or time points. Results suggest that changes in blood pressure and augmentation index vary depending on the intensity of resistance exercise regardless of the volume of exercise carried out. Changes in AIx75 in response to resistance exercise may be independent of changes in BP.

High Intensity Resistance Exercise Training to Improve Body Composition and Strength in Older Men With Osteosarcopenia. Results of the Randomized Controlled Franconian Osteopenia and Sarcopenia Trial (FrOST).

Considerably decreased muscle mass and function are subsumed under “sarcopenia,” a geriatric syndrome. Dedicated exercise programs maintain muscle mass and function; however, due to the limited enthusiasm of older adults to exercise, it is important to generate low-threshold interventions for this vulnerable cohort. Thus, the primary aim of this study was to determine the effect of low volume/high intensity resistance exercise training (HIT-RT) combined with protein supplementation on body composition and strength in older men with sarcopenia and osteopenia (osteosarcopenia). Forty-three community-dwelling (cdw) older men (78 ± 4 years) with osteosarcopenia were randomly allocated to a consistently supervised HIT-RT (n = 21) or an inactive control group (CG, n = 22). HIT-RT scheduled a single set protocol with high intensity and effort applied twice a week for 36 weeks so far. Both groups were supplemented with Vit-D (800 IE/d), calcium (1,000 mg/d) and whey-protein (CG: 1.2 vs. HIT-RT: 1.5–1.7 g/kg/d). Study endpoints were body composition (dual-energy x-ray absorptiometry) and maximum isokinetic hip/leg-extensor strength (MIES) by leg-press. After 36 weeks, one participant who developed prostate cancer after inclusion in the study (HIT-RT) and two participants who lost interest (CG, HIT-RT) quit the study. Attendance rate for HIT-RT averaged 93 ± 5%. Total and thigh lean body mass (LBM) significantly (p < 0.001) increased in the HIT-RT and was maintained in the CG (p = 0.46 and 0.37). Differences between the groups for changes of total and thigh LBM were pronounced (p < 0.001; SMD d′ = 1.17 and 1.20). Total and abdominal body fat percentage decreased significantly in the HIT-RT (p < 0.001) and increased in the CG (p = 0.039 and p = 0.097). Intergroup differences were significant (p < 0.001; SMD: d′ = 1.35 and 1.28). Finally, MIES was maintained in the CG (p = 0.860), and improved significantly (p < 0.001) in the HIT-RT. Differences between the groups were significant (p < 0.001, SMD: d′ = 2.41). No adverse effects of the intervention were observed. In summary, the HIT-RT/protein protocol significantly affected body composition and strength in cdw men 72 years+ with osteosarcopenia. In the absence of negative side effects, the intervention was feasible, attractive and time effective. Thus, we conclude that supervised HIT-RT might be an exercise option for older men.

An Intense, But Ecologically Valid, Resistance Exercise Session Does Not Alter Growth Factors Associated With Cognitive Health.

The purpose of this investigation was to assess the acute changes in growth factors associated with cognitive health following two ecologically valid, intense resistance exercise sessions. Twenty-nine late-middle-aged adults performed one session of either (a)moderate-load resistance exercise or (b)high-load resistance exercise. Venous blood was collected prior to warm-up, immediately following exercise and 30min following exercise. Serum was analyzed for brain-derived neurotrophic factor, insulin-like growth factor 1, and vascular endothelial growth factor. Session intensity was determined by blood lactate concentration and session rating of perceived exertion. Postexercise blood lactate was greater following moderate-load when compared with high-load resistance exercise. Subjective session intensity was rated higher by the session rating of perceived exertion following moderate-load when compared with high-load resistance exercise. No differences were observed in serum growth factor levels between groups. Ecologically valid and intense moderate-load or high-load exercise methods do not alter serum growth factor levels in late-middle-aged adults.

Benefits of higher resistance-training volume are related to ribosome biogenesis.

For individuals showing suboptimal adaptations to resistance training, manipulation of training volume is a potential measure to facilitate responses. This remains unexplored. Here, 34 untrained individuals performed contralateral resistance training with moderate and low volume for 12weeks. Moderate volume led to larger increases in muscle cross-sectional area, strength and type II fibre-type transitions. These changes coincided with greater activation of signalling pathways controlling muscle growth and greater induction of ribosome synthesis. Out of 34 participants, thirteen displayed clear benefit of MOD on muscle hypertrophy and sixteen showed clear benefit of MOD on muscle strength gains. This coincided with greater total RNA accumulation in the early phase of the training period, suggesting that ribosomal biogenesis regulates the dose-response relationship between training volume and muscle hypertrophy. These results demonstrate that there is a dose-dependent relationship between training volume and outcomes. On the individual level, benefits of higher training volume were associated with increased ribosomal biogenesis. Resistance-exercise volume is a determinant of training outcomes. However not all individuals respond in a dose-dependent fashion. In this study, 34 healthy individuals (males n=16, 23.6 (4.1)years; females n=18, 22.0 (1.3)years) performed moderate- (3 sets per exercise, MOD) and low-volume (1 set, LOW) resistance training in a contralateral fashion for 12weeks (2-3 sessionsper week). Muscle cross-sectional area (CSA) and strength were assessed at Weeks 0 and 12, along with biopsy sampling (m. vastus lateralis). Muscle biopsies were also sampled before and 1h after the fifth session (Week 2). MOD resulted in larger increases in muscle CSA (5.2 (3.8)% versus 3.7 (3.7)%, P<0.001) and strength (3.4-7.7% difference, all P<0.05. This coincided with greater reductions in type IIX fibres from Week0 to Week12 (MOD, -4.6 percentage points; LOW -3.2 percentage points), greater phosphorylation of S6-kinase1 (p85 S6K1Thr412 , 19%; p70 S6K1Thr389 , 58%) and ribosomal protein S6Ser235/236 (37%), greater rested-state total RNA (8.8%) and greater exercise-induced c-Myc mRNA expression (25%; Week2, all P<0.05). Thirteen and sixteen participants, respectively, displayed clear benefits in response to MOD on muscle hypertrophy and strength. Benefits were associated with greater accumulation of total RNA at Week2 in the MOD leg, with every 1% difference increasing the odds of MOD benefit by 7.0% (P=0.005) and 9.8% (P=0.002). In conclusion, MOD led to greater functional and biological adaptations than LOW. Associations between dose-dependent total RNA accumulation and increases in muscle mass and strength point to ribosome biogenesis as a determinant of dose-dependent training responses.