At present, substations are developing vigorously in an intelligent direction. In this paper, an intelligent operation inspection platform based on a multi-agent system is designed. The platform’s design includes the design of its physical architecture and its operation architecture. The physical architecture of the platform includes a substation main control server, fixed live line measurement device, intelligent operation inspection software, intelligent data centralization device, intelligent interface conversion device, wireless communication channel, etc. In terms of platform operation architecture, an operation framework based on a multi-agent system is designed, including the “environment” layer, data sensing layer, data processing layer, and analysis and decision layer, and the whole platform is built based on the concept of edge computing. To solve the task allocation problem of edge computing, a Markov decision model is designed to minimize time consumption and maximize resource utilization, and the deep Q network (DQN) algorithm is used to solve the problem. The design aims at being effective, practical, safe, compatible, easy to upgrade, and extensible, and builds an intelligent operation inspection platform for live line measurement of substation equipment based on a multi-agent system, to improve the intelligent automation level of substation operation inspection.