Project-based practical teaching is an important part of the teaching reform of fashion design and intelligent manufacturing industry course in vocational colleges, and also an important measure to enhance the effectiveness of teaching. A good practical teaching base is a strong guarantee for the smooth development of project-based teaching. This paper explores the reform and innovation of project-based teaching of fashion design and intelligent manufacturing specialty, and further studies the construction of project-based base focusing on base practice teaching and online courses, to further integrate project-based teaching resources, give play to the role of network-based virtual platform, build perfect project processes, improve project-based teaching course resources of base, and realize co-building and sharing of teaching resources between colleges and enterprises, so as to further improve the teaching quality of project-based teaching of fashion design and intelligent manufacturing specialty, and develop more qualified technical talents.