AbstractShape memory epoxy thermosets (SMETs) have attracted more and more attention in artificial intelligence applications. However, the fabrication of lightweight and high‐strength bio‐based SMET with multiple‐response shape memory properties remains a challenge. Herein, a thermal and light‐triggered bio‐based SMET with excellent mechanical property and toughness is prepared. To fabricate the SMET, a bio‐based curing agent (CFMA) derived from cardanol, menthane diamine and furfural is utilized to react with epoxy resin E51 to prepare the SMET. The curing kinetics of SMET is measured by non‐isothermal DSC, and the reaction order is 0.784. The SMETs have excellent thermal stability and mechanical strength. Based on the toughening effect of the bio‐based curing agent, the SMETs exhibit excellent stretchability, and the toughness of the SMETs improves gradually with the increase in curing agent content. Furthermore, the SMET exhibits excellent thermal and light‐triggered shape memory properties, and the SMET with broad glass transition shows triple‐shape memory property. These multiple stimulus–response bio‐based SMETs with lightweight and high strength have potential applications in the field of actuators and intelligent electronic devices.